Title: Understanding tumour dynamics in vivo : the potential of kinetic models in radio-oncology
Authors : Scheidegger, Stephan
Lutters, Gerd
Bodis, Stephan
Proceedings: SSRMP Annual Scientific Meeting 2009 : University Hospital Basel 19th and 20th of November 2009: Abstracts & Proceedings
Pages : 18
Pages to: 23
Conference details: SSRMP Annual Scientific Meeting 2009, Schweizerische Gesellschaft für Strahlenbiologie und Medizinische Physik, Basel, 19–20 November 2009
Issue Date: 2009
License (according to publishing contract) : Licence according to publishing contract
Type of review: Not specified
Language : English
Subjects : Linear-quadratic model; DNA repair; Fractionated radiotherapy; Growth inhibition
Subject (DDC) : 571: Physiology and related subjects
615: Pharmacology and therapeutics
Abstract: To facilitate the investigation of the tumour response onto radiation therapy in vivo, a modified kinetic LQ-model is developed. It is based on a dose quantity which is considered as proportional to cellular damage. The resulting differential equations are implemented in a computer program and solved numerically. The model is in agreement with the kinetic model of Carlone. In contrast to the model of Carlone and other models focussing DNA lesion kinetics, different aspects of tissue dynamics (e.g. repopulation, oxygenation) can be integrated directly in the proposed LQ-based model.
Departement: School of Engineering
Publication type: Conference Paper
ISBN: 3-908-125-49-9
URI: https://digitalcollection.zhaw.ch/handle/11475/3560
Appears in Collections:Publikationen School of Engineering

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