Title: Effect of high dose per pulse flattening filter-free beams on cancer cell survival
Authors : Lohse, Ines
Lang, Stephanie
Hrbacek, Jan
Scheidegger, Stephan
Bodis, Stephan
Sanchez-Macedo, Nadia
Feng, Jianhua
Lütolf, Urs M.
Zaugg, Kathrin
Published in : Radiotherapy and Oncology
Volume(Issue) : 101
Issue : 1
Pages : 226
Pages to: 232
Publisher / Ed. Institution : Elsevier
Issue Date: 2011
License (according to publishing contract) : Licence according to publishing contract
Type of review: Peer review (Publication)
Language : English
Subjects : Cancer cell survival; Flattening filter; Radiotherapy; High dose
Subject (DDC) : 571: Physiology and related subjects
615: Pharmacology and therapeutics
Abstract: Purpose To investigate if there is a statistically significant difference in cancer cell survival using a high dose per pulse flattening filter-free (FFF) beam compared to a standard flattened beam. Material and methods To validate the radiobiological effect of the flattened and FFF beam, two glioblastoma cell lines were treated with either 5 or 10 Gy using different dose rates. Dose verification was performed and colony formation assays were carried out. To compare the predictability of our data, radiobiological models were included. Results The results presented here demonstrate that irradiation of glioblastoma cell lines using the FFF beam is more efficient in reducing clonogenic cell survival than the standard flattened beam, an effect which becomes more significant the higher the single dose. Interestingly, in our experimental setting, the radiobiological effect of the FFF beam is dependent on dose per pulse rather than on delivery time. The used radiobiological models are able to describe the observed dose rate dependency between 6 and 24 Gy/min. Conclusion The results presented here show that dose per pulse might become a crucial factor which influences cancer cell survival. Using high dose rates, currently used radiobiological models as well as molecular mechanisms involved urgently need to be re-examined.
Departement: School of Engineering
Publication type: Article in scientific Journal
DOI : 10.1016/j.radonc.2011.05.072
ISSN: 0167-8140
URI: https://digitalcollection.zhaw.ch/handle/11475/3542
Appears in Collections:Publikationen School of Engineering

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