Soft injectable sutures for dose-controlled and continuous drug delivery

Alsaedi, Mossab K.; Lone, Omar; Nejad, Hojatollah Rezaei; Das, Riddha; Owyeung, Rachel E.; Del-Rio-Ruiz, Ruben; Sonkusale, Sameer

doi:10.1002/mabi.202300365

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Soft injectable sutures for dose-controlled and continuous drug delivery
Authors:	Alsaedi, Mossab K. Lone, Omar Nejad, Hojatollah Rezaei Das, Riddha Owyeung, Rachel E. Del-Rio-Ruiz, Ruben Sonkusale, Sameer
et. al:	No
DOI:	10.1002/mabi.202300365
Published in:	Macromolecular Bioscience
Volume(Issue):	24
Issue:	3
Page(s):	2300365
Issue Date:	Mar-2024
Publisher / Ed. Institution:	Wiley
ISSN:	1616-5187 1616-5195
Language:	English
Subjects:	Chemotherapy; Implant; Injectables; Smart thread; Sutures; Transdermal drug delivery; Cutaneous administration; Drug delivery system
Subject (DDC):	610.28: Biomedicine, biomedical engineering
Abstract:	Transdermal drug delivery offers a promising alternative to traditional methods such as oral ingestion and hypodermic injection. Hypodermic injections are painful, while oral ingestion requires higher doses due to enzymatic degradation and poor absorption. While microneedles address the pain issue, they are limited to delivering small amounts of drugs and can be impractical due to peeling off with motion and sweat. Herein, this work proposes soft injectables using drug-carrying sutures for painless and localized sustained delivery in the dermis. These sutures can remain in place during delivery and are suitable for all skin types. Surgical sutures can also serve as open capillary microfluidic channels carrying drug from a wearable drug reservoir to enable long-term (weeks to months) transdermal drug delivery. The experiments focus on delivering 5-fluorouracil (5-FU), a cancer drug, and rhodamine B, a drug model. A fixed-length suture of 60 cm delivers 0.43 mg of 5-flurouracil in 15 min. The experiments also demonstrate a continuous drug delivery of rhodamine B for over 8 weeks at a rate of 0.0195 mL h-1 . The results highlight that soft injectable sutures are promising candidates for long-term sustained delivery of varying quantities of drugs over weeks period compared to hypodermic injection, oral ingestion, or microneedles.
URI:	https://digitalcollection.zhaw.ch/handle/11475/30786
Fulltext version:	Published version
License (according to publishing contract):	Licence according to publishing contract
Departement:	School of Engineering
Organisational Unit:	Institute of Computational Physics (ICP)
Appears in collections:	Publikationen School of Engineering

Files in This Item:

There are no files associated with this item.

Show full item record

Alsaedi, M. K., Lone, O., Nejad, H. R., Das, R., Owyeung, R. E., Del-Rio-Ruiz, R., & Sonkusale, S. (2024). Soft injectable sutures for dose-controlled and continuous drug delivery. Macromolecular Bioscience, 24(3), 2300365. https://doi.org/10.1002/mabi.202300365

Alsaedi, M.K. et al. (2024) ‘Soft injectable sutures for dose-controlled and continuous drug delivery’, Macromolecular Bioscience, 24(3), p. 2300365. Available at: https://doi.org/10.1002/mabi.202300365.

M. K. Alsaedi et al., “Soft injectable sutures for dose-controlled and continuous drug delivery,” Macromolecular Bioscience, vol. 24, no. 3, p. 2300365, Mar. 2024, doi: 10.1002/mabi.202300365.

ALSAEDI, Mossab K., Omar LONE, Hojatollah Rezaei NEJAD, Riddha DAS, Rachel E. OWYEUNG, Ruben DEL-RIO-RUIZ und Sameer SONKUSALE, 2024. Soft injectable sutures for dose-controlled and continuous drug delivery. Macromolecular Bioscience. März 2024. Bd. 24, Nr. 3, S. 2300365. DOI 10.1002/mabi.202300365

Alsaedi, Mossab K., Omar Lone, Hojatollah Rezaei Nejad, Riddha Das, Rachel E. Owyeung, Ruben Del-Rio-Ruiz, and Sameer Sonkusale. 2024. “Soft Injectable Sutures for Dose-Controlled and Continuous Drug Delivery.” Macromolecular Bioscience 24 (3): 2300365. https://doi.org/10.1002/mabi.202300365.

Alsaedi, Mossab K., et al. “Soft Injectable Sutures for Dose-Controlled and Continuous Drug Delivery.” Macromolecular Bioscience, vol. 24, no. 3, Mar. 2024, p. 2300365, https://doi.org/10.1002/mabi.202300365.