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https://doi.org/10.21256/zhaw-30704| Publication type: | Article in scientific journal |
| Type of review: | Peer review (publication) |
| Title: | Light-coupled cryogenic probes to detect low-micromolar samples and allow for an automated NMR platform |
| Authors: | Wüster, Wolf Gebbers, Pit Renn, Alois Bütikofer, Matthias Rüdiger, Sophie Riek, Roland P. Torres, Felix |
| et. al: | No |
| DOI: | 10.5194/mr-5-61-2024 10.21256/zhaw-30704 |
| Published in: | Magnetic Resonance |
| Volume(Issue): | 5 |
| Issue: | 1 |
| Page(s): | 61 |
| Pages to: | 67 |
| Issue Date: | 2024 |
| Publisher / Ed. Institution: | Copernicus Publications |
| ISSN: | 2699-0016 |
| Language: | English |
| Subjects: | Nuclear magnetic resonance (NMR); Photo-CIDNP; Hyperpolarization |
| Subject (DDC): | 530: Physics |
| Abstract: | Recent advances in NMR fragment screening use sample illumination to boost NMR sensitivity, reduce measurement time to a few seconds, and reduce sample concentration to a few micromolars. Nevertheless, the absence of a fully automated solution to measure several hundreds of samples with photoinduced hyperpolarization limits the large-scale applicability of the method. We present a setup to couple an optical fiber with a cryogenic probe using the flow-cell accessory port. This setup is compatible with commercially available autosamplers, enabling the fully automated measurement of several hundreds of samples per day. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/30704 |
| Fulltext version: | Published version |
| License (according to publishing contract): | CC BY 4.0: Attribution 4.0 International |
| Departement: | School of Engineering |
| Organisational Unit: | Institute of Applied Mathematics and Physics (IAMP) |
| Published as part of the ZHAW project: | Off-the-shelf upgrade to improve drug screening throughput by a factor 30 |
| Appears in collections: | Publikationen School of Engineering |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 2024_Wuester-etal_Light-coupled-cryogenic-probes-NMR-Platform_MR.pdf | 1.43 MB | Adobe PDF |  View/Open |
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Wüster, W., Gebbers, P., Renn, A., Bütikofer, M., Rüdiger, S., Riek, R. P., & Torres, F. (2024). Light-coupled cryogenic probes to detect low-micromolar samples and allow for an automated NMR platform. Magnetic Resonance, 5(1), 61–67. https://doi.org/10.5194/mr-5-61-2024
Wüster, W. et al. (2024) ‘Light-coupled cryogenic probes to detect low-micromolar samples and allow for an automated NMR platform’, Magnetic Resonance, 5(1), pp. 61–67. Available at: https://doi.org/10.5194/mr-5-61-2024.
W. Wüster et al., “Light-coupled cryogenic probes to detect low-micromolar samples and allow for an automated NMR platform,” Magnetic Resonance, vol. 5, no. 1, pp. 61–67, 2024, doi: 10.5194/mr-5-61-2024.
WÜSTER, Wolf, Pit GEBBERS, Alois RENN, Matthias BÜTIKOFER, Sophie RÜDIGER, Roland P. RIEK und Felix TORRES, 2024. Light-coupled cryogenic probes to detect low-micromolar samples and allow for an automated NMR platform. Magnetic Resonance. 2024. Bd. 5, Nr. 1, S. 61–67. DOI 10.5194/mr-5-61-2024
Wüster, Wolf, Pit Gebbers, Alois Renn, Matthias Bütikofer, Sophie Rüdiger, Roland P. Riek, and Felix Torres. 2024. “Light-Coupled Cryogenic Probes to Detect Low-Micromolar Samples and Allow for an Automated NMR Platform.” Magnetic Resonance 5 (1): 61–67. https://doi.org/10.5194/mr-5-61-2024.
Wüster, Wolf, et al. “Light-Coupled Cryogenic Probes to Detect Low-Micromolar Samples and Allow for an Automated NMR Platform.” Magnetic Resonance, vol. 5, no. 1, 2024, pp. 61–67, https://doi.org/10.5194/mr-5-61-2024.
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