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https://doi.org/10.21256/zhaw-30308| Publication type: | Article in scientific journal |
| Type of review: | Peer review (publication) |
| Title: | Theoretical evaluation of the impact of diverse treatment conditions by calculation of the tumor control probability (TCP) of simulated cervical cancer Hyperthermia-Radiotherapy (HT-RT) treatments in-silico |
| Authors: | Mingo Barba, Sergio Ademaj, Adela Marder, Dietmar Riesterer, Oliver Lattuada, Marco Füchslin, Rudolf Marcel Petri-Fink, Alke Scheidegger, Stephan |
| et. al: | No |
| DOI: | 10.1080/02656736.2024.2320852 10.21256/zhaw-30308 |
| Published in: | International Journal of Hyperthermia |
| Volume(Issue): | 41 |
| Issue: | 1 |
| Page(s): | 2320852 |
| Issue Date: | 2024 |
| Publisher / Ed. Institution: | Taylor & Francis |
| ISSN: | 0265-6736 1464-5157 |
| Language: | English |
| Subjects: | Tumor control probability; Thermoradiotherapy; Hyperthermia; Biological modeling; Treatment condition |
| Subject (DDC): | 616: Internal medicine and diseases |
| Abstract: | Introduction: Hyperthermia (HT) induces various cellular biological processes, such as repair impairment and direct HT cell killing. In this context, in-silico biophysical models that translate deviations in the treatment conditions into clinical outcome variations may be used to study the extent of such processes and their influence on combined hyperthermia plus radiotherapy (HT + RT) treatments under varying conditions. Methods: An extended linear-quadratic model calibrated for SiHa and HeLa cell lines (cervical cancer) was used to theoretically study the impact of varying HT treatment conditions on radiosensitization and direct HT cell killing effect. Simulated patients were generated to compute the Tumor Control Probability (TCP) under different HT conditions (number of HT sessions, temperature and time interval), which were randomly selected within margins based on reported patient data. Results: Under the studied conditions, model-based simulations suggested a treatment improvement with a total CEM43 thermal dose of approximately 10 min. Additionally, for a given thermal dose, TCP increased with the number of HT sessions. Furthermore, in the simulations, we showed that the TCP dependence on the temperature/time interval is more correlated with the mean value than with the minimum/maximum value and that comparing the treatment outcome with the mean temperature can be an excellent strategy for studying the time interval effect. Conclusion: The use of thermoradiobiological models allows us to theoretically study the impact of varying thermal conditions on HT + RT treatment outcomes. This approach can be used to optimize HT treatments, design clinical trials, and interpret patient data. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/30308 |
| Related research data: | https://github.com/mingzhaw/TCP_paper |
| Fulltext version: | Published version |
| License (according to publishing contract): | CC BY 4.0: Attribution 4.0 International |
| Departement: | School of Engineering |
| Organisational Unit: | Institute of Applied Mathematics and Physics (IAMP) |
| Published as part of the ZHAW project: | Hyperboost |
| Appears in collections: | Publikationen School of Engineering |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| 2024_MingoBarba-etal_TCP-calculation-impact-of-diverse-treatment-conditions.pdf | 7.03 MB | Adobe PDF |  View/Open |
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Mingo Barba, S., Ademaj, A., Marder, D., Riesterer, O., Lattuada, M., Füchslin, R. M., Petri-Fink, A., & Scheidegger, S. (2024). Theoretical evaluation of the impact of diverse treatment conditions by calculation of the tumor control probability (TCP) of simulated cervical cancer Hyperthermia-Radiotherapy (HT-RT) treatments in-silico. International Journal of Hyperthermia, 41(1), 2320852. https://doi.org/10.1080/02656736.2024.2320852
Mingo Barba, S. et al. (2024) ‘Theoretical evaluation of the impact of diverse treatment conditions by calculation of the tumor control probability (TCP) of simulated cervical cancer Hyperthermia-Radiotherapy (HT-RT) treatments in-silico’, International Journal of Hyperthermia, 41(1), p. 2320852. Available at: https://doi.org/10.1080/02656736.2024.2320852.
S. Mingo Barba et al., “Theoretical evaluation of the impact of diverse treatment conditions by calculation of the tumor control probability (TCP) of simulated cervical cancer Hyperthermia-Radiotherapy (HT-RT) treatments in-silico,” International Journal of Hyperthermia, vol. 41, no. 1, p. 2320852, 2024, doi: 10.1080/02656736.2024.2320852.
MINGO BARBA, Sergio, Adela ADEMAJ, Dietmar MARDER, Oliver RIESTERER, Marco LATTUADA, Rudolf Marcel FÜCHSLIN, Alke PETRI-FINK und Stephan SCHEIDEGGER, 2024. Theoretical evaluation of the impact of diverse treatment conditions by calculation of the tumor control probability (TCP) of simulated cervical cancer Hyperthermia-Radiotherapy (HT-RT) treatments in-silico. International Journal of Hyperthermia. 2024. Bd. 41, Nr. 1, S. 2320852. DOI 10.1080/02656736.2024.2320852
Mingo Barba, Sergio, Adela Ademaj, Dietmar Marder, Oliver Riesterer, Marco Lattuada, Rudolf Marcel Füchslin, Alke Petri-Fink, and Stephan Scheidegger. 2024. “Theoretical Evaluation of the Impact of Diverse Treatment Conditions by Calculation of the Tumor Control Probability (TCP) of Simulated Cervical Cancer Hyperthermia-Radiotherapy (HT-RT) Treatments In-Silico.” International Journal of Hyperthermia 41 (1): 2320852. https://doi.org/10.1080/02656736.2024.2320852.
Mingo Barba, Sergio, et al. “Theoretical Evaluation of the Impact of Diverse Treatment Conditions by Calculation of the Tumor Control Probability (TCP) of Simulated Cervical Cancer Hyperthermia-Radiotherapy (HT-RT) Treatments In-Silico.” International Journal of Hyperthermia, vol. 41, no. 1, 2024, p. 2320852, https://doi.org/10.1080/02656736.2024.2320852.
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