| Publication type: | Book part |
| Type of review: | Editorial review |
| Title: | Single-use systems in biopharmaceutical manufacture : state of the art and recent trends |
| Authors: | Jossen, Valentin Eibl-Schindler, Regine Broccard, Gilles Eibl, Dieter |
| et. al: | No |
| DOI: | 10.1007/978-3-031-45669-5_1 |
| Published in: | Biopharmaceutical Manufacturing : Progress, Trends and Challenges |
| Editors of the parent work: | Pörtner, Ralf |
| Page(s): | 3 |
| Pages to: | 38 |
| Issue Date: | 2023 |
| Series: | Cell Engineering |
| Series volume: | 11 |
| Publisher / Ed. Institution: | Springer |
| Publisher / Ed. Institution: | Cham |
| ISBN: | 978-3-031-45668-8 978-3-031-45669-5 |
| Language: | English |
| Subjects: | Biopharmaceuticals; Downstreaming; Fill & finish; Process intensification; Single-use; Upstreaming |
| Subject (DDC): | 660.6: Biotechnology |
| Abstract: | Single-use systems have become increasingly important in recent years. This applies in particular to their use in the manufacture of biopharmaceutical products based on mammalian cell cultures, such as antibodies for the therapy of cancer and autoimmune diseases. Today, developers and manufacturers of such biotherapeutics can choose from a large product portfolio of single-use systems from different suppliers. For example, there are single-use versions of storage bags, filters, mixers, bioreactors, connectors, harvesting and transfer systems, membrane adsorbers, freeze- and -thaw systems, to name just a few examples. Thus, the production of clinical samples in complete single-use production facilities (upstream processing to filling) is already a reality. Based on the definition of the term and the presentation of milestones in the development of single-use technology, the book chapter discusses the most important advantages and existing limitations of the single-use systems currently available on the market. Subsequently, the current state of development of single-use technology is presented on the basis of selected product examples. The focus is on the upstream area and single-use bioreactors. Finally, approaches for process intensification up to complete continuous production resulting from the increasing implementation of single-use systems are deduced. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/30136 |
| Fulltext version: | Published version |
| License (according to publishing contract): | Licence according to publishing contract |
| Departement: | Life Sciences and Facility Management |
| Organisational Unit: | Institute of Chemistry and Biotechnology (ICBT) |
| Appears in collections: | Publikationen Life Sciences und Facility Management |
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Jossen, V., Eibl-Schindler, R., Broccard, G., & Eibl, D. (2023). Single-use systems in biopharmaceutical manufacture : state of the art and recent trends. In R. Pörtner (Ed.), Biopharmaceutical Manufacturing : Progress, Trends and Challenges (pp. 3–38). Springer. https://doi.org/10.1007/978-3-031-45669-5_1
Jossen, V. et al. (2023) ‘Single-use systems in biopharmaceutical manufacture : state of the art and recent trends’, in R. Pörtner (ed.) Biopharmaceutical Manufacturing : Progress, Trends and Challenges. Cham: Springer, pp. 3–38. Available at: https://doi.org/10.1007/978-3-031-45669-5_1.
V. Jossen, R. Eibl-Schindler, G. Broccard, and D. Eibl, “Single-use systems in biopharmaceutical manufacture : state of the art and recent trends,” in Biopharmaceutical Manufacturing : Progress, Trends and Challenges, R. Pörtner, Ed. Cham: Springer, 2023, pp. 3–38. doi: 10.1007/978-3-031-45669-5_1.
JOSSEN, Valentin, Regine EIBL-SCHINDLER, Gilles BROCCARD und Dieter EIBL, 2023. Single-use systems in biopharmaceutical manufacture : state of the art and recent trends. In: Ralf PÖRTNER (Hrsg.), Biopharmaceutical Manufacturing : Progress, Trends and Challenges. Cham: Springer. S. 3–38. ISBN 978-3-031-45668-8
Jossen, Valentin, Regine Eibl-Schindler, Gilles Broccard, and Dieter Eibl. 2023. “Single-Use Systems in Biopharmaceutical Manufacture : State of the Art and Recent Trends.” In Biopharmaceutical Manufacturing : Progress, Trends and Challenges, edited by Ralf Pörtner, 3–38. Cham: Springer. https://doi.org/10.1007/978-3-031-45669-5_1.
Jossen, Valentin, et al. “Single-Use Systems in Biopharmaceutical Manufacture : State of the Art and Recent Trends.” Biopharmaceutical Manufacturing : Progress, Trends and Challenges, edited by Ralf Pörtner, Springer, 2023, pp. 3–38, https://doi.org/10.1007/978-3-031-45669-5_1.
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