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dc.contributor.authorBagatella, S.-
dc.contributor.authorHaghayegh Jahromi, N.-
dc.contributor.authorMonney, C.-
dc.contributor.authorPolidori, M.-
dc.contributor.authorGall, F.M.-
dc.contributor.authorSerra, F.-
dc.contributor.authorRiedl, R.-
dc.contributor.authorEngelhardt, B.-
dc.contributor.authorOevermann, A.-
dc.date.accessioned2024-03-01T08:22:05Z-
dc.date.available2024-03-01T08:22:05Z-
dc.date.issued2022-10-08-
dc.identifier.issn0021-9975de_CH
dc.identifier.issn1532-3129de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/30071-
dc.description.abstractIntroduction: The bacterium Listeria monocytogenes (LM) can cause life-threatening central nervous system (CNS) infection (neurolisteriosis) in humans and ruminants. Polymorphonuclear neutrophils (PMNs) recruited into the CNS migrate to infectious foci to exert bacterial killing, but overzealous PMN recruitment is regularly linked to serious neural damage. Factors responsible for PMN chemotaxis to CNS infectious foci in neurolisteriosis remain obscure. Here, we aimed at identifying chemotactic factors (bacteria vs host-derived) for bovine PMNs in neurolisteriosis. Materials and methods: We performed ex-vivo chemotaxis assays with primary bovine PMNs to assess the chemotactic effect of LM components and supernatants of endogenous CNS cells infected with LM. IL-8 (main chemotactic candidate) expression was also assessed through ELISA and in-situ immunohistochemistry/immunofluorescence in CNS of naturally infected cattle. Results: Whole bacteria and LM cell wall components failed to elicit PMN chemotaxis, as did supernatants from LM-infected astrocytes and neural cells. Conversely, supernatant of LM-infected microglia proved chemotactic for PMNs. Moreover, microglial secretion of IL-8 was detected on in-vitro microglial infection and in microglia of cattle with neurolisteriosis in situ. Conclusions: Our results indicate that PMN chemotaxis to infectious foci in neurolisteriosis is independent of bacterial stimuli and is rather mediated by host-derived chemotactic factors (including IL-8) produced by microglia. Prevention of excessive PMN recruitment by blocking such factors may constitute a candidate therapeutic option to limit PMN-mediated CNS damage in neurolisteriosis.de_CH
dc.language.isoende_CH
dc.publisherElsevierde_CH
dc.relation.ispartofJournal of Comparative Pathologyde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subject.ddc572: Biochemiede_CH
dc.subject.ddc579: Mikrobiologiede_CH
dc.titleMicroglia, rather than bacterial factors, mediate bovine neutrophil chemotaxis in neurolisteriosisde_CH
dc.typeKonferenz: Sonstigesde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
dc.identifier.doi10.1016/j.jcpa.2023.03.073de_CH
zhaw.conference.detailsAnnual Congress of the European Society of Veterinary Pathology and European College of Veterinary Pathologists, Athens, Greece, September 7‒10, 2022de_CH
zhaw.funding.euNode_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.start61de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume203de_CH
zhaw.publication.reviewPeer review (Abstract)de_CH
zhaw.webfeedCC Drug Discoveryde_CH
zhaw.webfeedOrganische Chemiede_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
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Bagatella, S., Haghayegh Jahromi, N., Monney, C., Polidori, M., Gall, F. M., Serra, F., Riedl, R., Engelhardt, B., & Oevermann, A. (2022). Microglia, rather than bacterial factors, mediate bovine neutrophil chemotaxis in neurolisteriosis [Conference presentation]. Journal of Comparative Pathology, 203, 61. https://doi.org/10.1016/j.jcpa.2023.03.073
Bagatella, S. et al. (2022) ‘Microglia, rather than bacterial factors, mediate bovine neutrophil chemotaxis in neurolisteriosis’, in Journal of Comparative Pathology. Elsevier, p. 61. Available at: https://doi.org/10.1016/j.jcpa.2023.03.073.
S. Bagatella et al., “Microglia, rather than bacterial factors, mediate bovine neutrophil chemotaxis in neurolisteriosis,” in Journal of Comparative Pathology, Oct. 2022, vol. 203, p. 61. doi: 10.1016/j.jcpa.2023.03.073.
BAGATELLA, S., N. HAGHAYEGH JAHROMI, C. MONNEY, M. POLIDORI, F.M. GALL, F. SERRA, R. RIEDL, B. ENGELHARDT und A. OEVERMANN, 2022. Microglia, rather than bacterial factors, mediate bovine neutrophil chemotaxis in neurolisteriosis. In: Journal of Comparative Pathology. Conference presentation. Elsevier. 8 Oktober 2022. S. 61
Bagatella, S., N. Haghayegh Jahromi, C. Monney, M. Polidori, F.M. Gall, F. Serra, R. Riedl, B. Engelhardt, and A. Oevermann. 2022. “Microglia, rather than Bacterial Factors, Mediate Bovine Neutrophil Chemotaxis in Neurolisteriosis.” Conference presentation. In Journal of Comparative Pathology, 203:61. Elsevier. https://doi.org/10.1016/j.jcpa.2023.03.073.
Bagatella, S., et al. “Microglia, rather than Bacterial Factors, Mediate Bovine Neutrophil Chemotaxis in Neurolisteriosis.” Journal of Comparative Pathology, vol. 203, Elsevier, 2022, p. 61, https://doi.org/10.1016/j.jcpa.2023.03.073.


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