Minimal information for studies of extracellular vesicles (MISEV2023) : from basic to advanced approaches

Welsh, Joshua A.; Goberdhan, Deborah C. I.; O'Driscoll, Lorraine; Buzas, Edit I.; Blenkiron, Cherie; Bussolati, Benedetta; Cai, Houjian; Di Vizio, Dolores; Driedonks, Tom A. P.; Erdbrügger, Uta; Falcon-Perez, Juan M.; Fu, Qing-Ling; Hill, Andrew F.; Lenassi, Metka; Lim, Sai Kiang; Mahoney, Mỹ G.; Mohanty, Sujata; Möller, Andreas; Nieuwland, Rienk; Ochiya, Takahiro; Sahoo, Susmita; Torrecilhas, Ana C.; Zheng, Lei; Zijlstra, Andries; Abuelreich, Sarah; Bagabas, Reem; Bergese, Paolo; Bridges, Esther M.; Brucale, Marco; Burger, Dylan; Carney, Randy P.; Cocucci, Emanuele; Colombo, Federico; Crescitelli, Rossella; Eichenberger, Ramon; Hanser, Edveena; Harris, Adrian L.; Haughey, Norman J.; Hendrix, An; Ivanov, Alexander R.; Jovanovic-Talisman, Tijana; Kruh-Garcia, Nicole A.; Ku'ulei-Lyn Faustino, Vroniqa; Kyburz, Diego; Lässer, Cecilia; Lennon, Kathleen M.; Lötvall, Jan; Maddox, Adam L.; Martens-Uzunova, Elena S.; Mizenko, Rachel R.; Newman, Lauren A.; Ridolfi, Andrea; Rohde, Eva; Rojalin, Tatu; Rowland, Andrew; Saftics, Andras; Sandau, Ursula S.; Saugstad, Julie A.; Shekari, Faezeh; Swift, Simon; Ter-Ovanesyan, Dmitry; Tosar, Juan P.; Useckaite, Zivile; Valle, Francesco; Varga, Zoltan; van der Pol, Edwin; van Herwijnen, Martijn J. C.; Wauben, Marca H. M.; Wehman, Ann M.; Williams, Sarah; Zendrini, Andrea; Zimmerman, Alan J; Misev Consortium; Théry, Clotilde; Witwer, Kenneth W.

doi:10.1002/jev2.12404

Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-29924

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Minimal information for studies of extracellular vesicles (MISEV2023) : from basic to advanced approaches
Authors:	Welsh, Joshua A. Goberdhan, Deborah C. I. O'Driscoll, Lorraine Buzas, Edit I. Blenkiron, Cherie Bussolati, Benedetta Cai, Houjian Di Vizio, Dolores Driedonks, Tom A. P. Erdbrügger, Uta Falcon-Perez, Juan M. Fu, Qing-Ling Hill, Andrew F. Lenassi, Metka Lim, Sai Kiang Mahoney, Mỹ G. Mohanty, Sujata Möller, Andreas Nieuwland, Rienk Ochiya, Takahiro Sahoo, Susmita Torrecilhas, Ana C. Zheng, Lei Zijlstra, Andries Abuelreich, Sarah Bagabas, Reem Bergese, Paolo Bridges, Esther M. Brucale, Marco Burger, Dylan Carney, Randy P. Cocucci, Emanuele Colombo, Federico Crescitelli, Rossella Eichenberger, Ramon Hanser, Edveena Harris, Adrian L. Haughey, Norman J. Hendrix, An Ivanov, Alexander R. Jovanovic-Talisman, Tijana Kruh-Garcia, Nicole A. Ku'ulei-Lyn Faustino, Vroniqa Kyburz, Diego Lässer, Cecilia Lennon, Kathleen M. Lötvall, Jan Maddox, Adam L. Martens-Uzunova, Elena S. Mizenko, Rachel R. Newman, Lauren A. Ridolfi, Andrea Rohde, Eva Rojalin, Tatu Rowland, Andrew Saftics, Andras Sandau, Ursula S. Saugstad, Julie A. Shekari, Faezeh Swift, Simon Ter-Ovanesyan, Dmitry Tosar, Juan P. Useckaite, Zivile Valle, Francesco Varga, Zoltan van der Pol, Edwin van Herwijnen, Martijn J. C. Wauben, Marca H. M. Wehman, Ann M. Williams, Sarah Zendrini, Andrea Zimmerman, Alan J Misev Consortium Théry, Clotilde Witwer, Kenneth W.
et. al:	Yes
DOI:	10.1002/jev2.12404 10.21256/zhaw-29924
Published in:	Journal of Extracellular Vesicles
Volume(Issue):	13
Issue:	2
Page(s):	e12404
Issue Date:	7-Feb-2024
Publisher / Ed. Institution:	Wiley
ISSN:	2001-3078
Language:	English
Subjects:	MISEV; Ectosome; Exosome; Extracellular particle; Extracellular vesicle; Guideline; Microparticle; Microvesicle; Minimal information requirement; Reproducibility; Rigor; Standardisation; Biological transport; Biomarker; Phenotype
Subject (DDC):	571: Physiology and related subjects
Abstract:	Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its 'Minimal Information for Studies of Extracellular Vesicles', which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly.
URI:	https://digitalcollection.zhaw.ch/handle/11475/29924
Fulltext version:	Published version
License (according to publishing contract):	CC BY 4.0: Attribution 4.0 International
Departement:	Life Sciences and Facility Management
Organisational Unit:	Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:	Publikationen Life Sciences und Facility Management

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Welsh, J. A., Goberdhan, D. C. I., O’Driscoll, L., Buzas, E. I., Blenkiron, C., Bussolati, B., Cai, H., Di Vizio, D., Driedonks, T. A. P., Erdbrügger, U., Falcon-Perez, J. M., Fu, Q.-L., Hill, A. F., Lenassi, M., Lim, S. K., Mahoney, M. G., Mohanty, S., Möller, A., Nieuwland, R., et al. (2024). Minimal information for studies of extracellular vesicles (MISEV2023) : from basic to advanced approaches. Journal of Extracellular Vesicles, 13(2), e12404. https://doi.org/10.1002/jev2.12404

Welsh, J.A. et al. (2024) ‘Minimal information for studies of extracellular vesicles (MISEV2023) : from basic to advanced approaches’, Journal of Extracellular Vesicles, 13(2), p. e12404. Available at: https://doi.org/10.1002/jev2.12404.

J. A. Welsh et al., “Minimal information for studies of extracellular vesicles (MISEV2023) : from basic to advanced approaches,” Journal of Extracellular Vesicles, vol. 13, no. 2, p. e12404, Feb. 2024, doi: 10.1002/jev2.12404.

WELSH, Joshua A., Deborah C. I. GOBERDHAN, Lorraine O’DRISCOLL, Edit I. BUZAS, Cherie BLENKIRON, Benedetta BUSSOLATI, Houjian CAI, Dolores DI VIZIO, Tom A. P. DRIEDONKS, Uta ERDBRÜGGER, Juan M. FALCON-PEREZ, Qing-Ling FU, Andrew F. HILL, Metka LENASSI, Sai Kiang LIM, Mỹ G. MAHONEY, Sujata MOHANTY, Andreas MÖLLER, Rienk NIEUWLAND, Takahiro OCHIYA, Susmita SAHOO, Ana C. TORRECILHAS, Lei ZHENG, Andries ZIJLSTRA, Sarah ABUELREICH, Reem BAGABAS, Paolo BERGESE, Esther M. BRIDGES, Marco BRUCALE, Dylan BURGER, Randy P. CARNEY, Emanuele COCUCCI, Federico COLOMBO, Rossella CRESCITELLI, Ramon EICHENBERGER, Edveena HANSER, Adrian L. HARRIS, Norman J. HAUGHEY, An HENDRIX, Alexander R. IVANOV, Tijana JOVANOVIC-TALISMAN, Nicole A. KRUH-GARCIA, Vroniqa KU’ULEI-LYN FAUSTINO, Diego KYBURZ, Cecilia LÄSSER, Kathleen M. LENNON, Jan LÖTVALL, Adam L. MADDOX, Elena S. MARTENS-UZUNOVA, Rachel R. MIZENKO, Lauren A. NEWMAN, Andrea RIDOLFI, Eva ROHDE, Tatu ROJALIN, Andrew ROWLAND, Andras SAFTICS, Ursula S. SANDAU, Julie A. SAUGSTAD, Faezeh SHEKARI, Simon SWIFT, Dmitry TER-OVANESYAN, Juan P. TOSAR, Zivile USECKAITE, Francesco VALLE, Zoltan VARGA, Edwin VAN DER POL, Martijn J. C. VAN HERWIJNEN, Marca H. M. WAUBEN, Ann M. WEHMAN, Sarah WILLIAMS, Andrea ZENDRINI, Alan J ZIMMERMAN, Misev Consortium, Clotilde THÉRY und Kenneth W. WITWER, 2024. Minimal information for studies of extracellular vesicles (MISEV2023) : from basic to advanced approaches. Journal of Extracellular Vesicles. 7 Februar 2024. Bd. 13, Nr. 2, S. e12404. DOI 10.1002/jev2.12404

Welsh, Joshua A., Deborah C. I. Goberdhan, Lorraine O’Driscoll, Edit I. Buzas, Cherie Blenkiron, Benedetta Bussolati, Houjian Cai, et al. 2024. “Minimal Information for Studies of Extracellular Vesicles (MISEV2023) : From Basic to Advanced Approaches.” Journal of Extracellular Vesicles 13 (2): e12404. https://doi.org/10.1002/jev2.12404.

Welsh, Joshua A., et al. “Minimal Information for Studies of Extracellular Vesicles (MISEV2023) : From Basic to Advanced Approaches.” Journal of Extracellular Vesicles, vol. 13, no. 2, Feb. 2024, p. e12404, https://doi.org/10.1002/jev2.12404.