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https://doi.org/10.21256/zhaw-29657| Publication type: | Article in scientific journal |
| Type of review: | Peer review (publication) |
| Title: | Beneficial and harmful effects of tricyclic antidepressants for adults with major depressive disorder : a systematic review with meta-analysis and trial sequential analysis |
| Authors: | Kamp, Caroline Barkholt Petersen, Johanne Juul Faltermeier, Pascal Juul, Sophie Siddiqui, Faiza Barbateskovic, Marija Kristensen, Andreas Torp Moncrieff, Joanna Horowitz, Mark Abie Hengartner, Michael Pascal Kirsch, Irving Gluud, Christian Jakobsen, Janus Christian |
| et. al: | No |
| DOI: | 10.1136/bmjment-2023-300730 10.21256/zhaw-29657 |
| Published in: | BMJ Mental Health |
| Volume(Issue): | 27 |
| Issue: | 1 |
| Page(s): | e300730 |
| Issue Date: | 2024 |
| Publisher / Ed. Institution: | BMJ Publishing Group |
| ISSN: | 2755-9734 |
| Language: | English |
| Subject (DDC): | 615: Pharmacology and therapeutics 616.8: Neurology, diseases of nervous system |
| Abstract: | Question: Tricyclic antidepressants are used to treat depression worldwide, but the adverse effects have not been systematically assessed. Our objective was to assess the beneficial and harmful effects of all tricyclic antidepressants for adults with major depressive disorder. Study selection and analysis: We conducted a systematic review with meta-analysis and trial sequential analysis. We searched CENTRAL, MEDLINE, Embase, LILACS and other sources from inception to January 2023 for randomised clinical trials comparing tricyclic antidepressants versus placebo or ‘active placebo’ for adults with major depressive disorder. The primary outcomes were depressive symptoms measured on the 17-item Hamilton Depression Rating Scale (HDRS-17), serious adverse events and quality of life. The minimal important difference was defined as three points on the HDRS-17. Findings: We included 103 trials randomising 10 590 participants. All results were at high risk of bias, and the certainty of the evidence was very low or low. All trials only assessed outcomes at the end of the treatment period at a maximum of 12 weeks after randomisation. Meta-analysis and trial sequential analysis showed evidence of a beneficial effect of tricyclic antidepressants compared with placebo (mean difference −3.77 HDRS-17 points; 95% CI −5.91 to −1.63; 17 trials). Meta-analysis showed evidence of a harmful effect of tricyclic antidepressants compared with placebo on serious adverse events (OR 2.78; 95% CI 2.18 to 3.55; 35 trials), but the required information size was not reached. Only 2 out of 103 trials reported on quality of life and t-tests showed no evidence of a difference. Conclusions: The long-term effects of tricyclic antidepressants and the effects on quality of life are unknown. Short-term results suggest that tricyclic antidepressants may reduce depressive symptoms while also increasing the risks of serious adverse events, but these results were based on low and very low certainty evidence. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/29657 |
| Fulltext version: | Published version |
| License (according to publishing contract): | CC BY-NC 4.0: Attribution - Non commercial 4.0 International |
| Departement: | Applied Psychology |
| Organisational Unit: | Psychological Institute (PI) |
| Appears in collections: | Publikationen Angewandte Psychologie |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 2024_BarkholtKamp-etal_Effects-of-tricyclic-antidepressants-for-adults.pdf | 5.31 MB | Adobe PDF |  View/Open |
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Kamp, C. B., Petersen, J. J., Faltermeier, P., Juul, S., Siddiqui, F., Barbateskovic, M., Kristensen, A. T., Moncrieff, J., Horowitz, M. A., Hengartner, M. P., Kirsch, I., Gluud, C., & Jakobsen, J. C. (2024). Beneficial and harmful effects of tricyclic antidepressants for adults with major depressive disorder : a systematic review with meta-analysis and trial sequential analysis. BMJ Mental Health, 27(1), e300730. https://doi.org/10.1136/bmjment-2023-300730
Kamp, C.B. et al. (2024) ‘Beneficial and harmful effects of tricyclic antidepressants for adults with major depressive disorder : a systematic review with meta-analysis and trial sequential analysis’, BMJ Mental Health, 27(1), p. e300730. Available at: https://doi.org/10.1136/bmjment-2023-300730.
C. B. Kamp et al., “Beneficial and harmful effects of tricyclic antidepressants for adults with major depressive disorder : a systematic review with meta-analysis and trial sequential analysis,” BMJ Mental Health, vol. 27, no. 1, p. e300730, 2024, doi: 10.1136/bmjment-2023-300730.
KAMP, Caroline Barkholt, Johanne Juul PETERSEN, Pascal FALTERMEIER, Sophie JUUL, Faiza SIDDIQUI, Marija BARBATESKOVIC, Andreas Torp KRISTENSEN, Joanna MONCRIEFF, Mark Abie HOROWITZ, Michael Pascal HENGARTNER, Irving KIRSCH, Christian GLUUD und Janus Christian JAKOBSEN, 2024. Beneficial and harmful effects of tricyclic antidepressants for adults with major depressive disorder : a systematic review with meta-analysis and trial sequential analysis. BMJ Mental Health. 2024. Bd. 27, Nr. 1, S. e300730. DOI 10.1136/bmjment-2023-300730
Kamp, Caroline Barkholt, Johanne Juul Petersen, Pascal Faltermeier, Sophie Juul, Faiza Siddiqui, Marija Barbateskovic, Andreas Torp Kristensen, et al. 2024. “Beneficial and Harmful Effects of Tricyclic Antidepressants for Adults with Major Depressive Disorder : A Systematic Review with Meta-Analysis and Trial Sequential Analysis.” BMJ Mental Health 27 (1): e300730. https://doi.org/10.1136/bmjment-2023-300730.
Kamp, Caroline Barkholt, et al. “Beneficial and Harmful Effects of Tricyclic Antidepressants for Adults with Major Depressive Disorder : A Systematic Review with Meta-Analysis and Trial Sequential Analysis.” BMJ Mental Health, vol. 27, no. 1, 2024, p. e300730, https://doi.org/10.1136/bmjment-2023-300730.
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