Hippocampal volume and parahippocampal cingulum alterations are associated with avoidant attachment in patients with depression

Bracht, Tobias; Denier, Niklaus; Wallimann, Meret; Walther, Sebastian; Mertse, Nicolas; Breit, Sigrid; Federspiel, Andrea; Wiest, Roland; Soravia, Leila

doi:10.1016/j.jadr.2022.100435

Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-29656

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Hippocampal volume and parahippocampal cingulum alterations are associated with avoidant attachment in patients with depression
Authors:	Bracht, Tobias Denier, Niklaus Wallimann, Meret Walther, Sebastian Mertse, Nicolas Breit, Sigrid Federspiel, Andrea Wiest, Roland Soravia, Leila
et. al:	No
DOI:	10.1016/j.jadr.2022.100435 10.21256/zhaw-29656
Published in:	Journal of Affective Disorders Reports
Volume(Issue):	10
Issue:	100435
Issue Date:	2022
Publisher / Ed. Institution:	Elsevier
ISSN:	2666-9153
Language:	English
Subjects:	Depression; Attachment; Hippocampus; Cingulum; White matter; Diffusion tensor imaging
Subject (DDC):	616.8: Neurology, diseases of nervous system
Abstract:	Background: Insecure attachment style (anxious and avoidant) predisposes to the development of depression and has been linked to hippocampal alterations in healthy individuals. However, it is unclear if there are alterations of the hippocampus and the parahippocampal cingulum (PHC) in patients with depression. Methods: Forty-eight patients with major depressive disorder and 18 healthy controls underwent MP2RAGE and diffusion-weighted magnetic resonance imaging. Attachment characteristics were assessed with the revised adult attachment scale. Patients were classified into subgroups with low (anxious: n = 27; avoidant: n = 21) and high (anxious: n = 20; avoidant: n = 28) attachment characteristics. Bilateral PHC were reconstructed using manual tractography. Hippocampal volumes, mean fractional anisotropy and mean diffusivity (MD) in bilateral PHC were compared between attachment subgroups and healthy controls. Results: Patients had higher scores of anxious and avoidant attachment, which were associated with depression severity. Patients with high avoidance had decreases in hippocampal volumes in comparison to patients with low avoidance. Furthermore, patients with high avoidance had increased MD in bilateral PHC in comparison to patients with low avoidance and in comparison to healthy controls. Limitations: Assessment of attachment characteristics may be influenced by cognitive biases due to depressive symptoms Conclusions: High attachment avoidance in patients with depression is associated with volume reductions in the hippocampus and impaired PHC-microstructure.
URI:	https://digitalcollection.zhaw.ch/handle/11475/29656
Fulltext version:	Published version
License (according to publishing contract):	CC BY-NC-ND 4.0: Attribution - Non commercial - No derivatives 4.0 International
Departement:	Social Work
Organisational Unit:	Institute of Childhood, Youth and Family (IKJF)
Appears in collections:	Publikationen Soziale Arbeit

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Bracht, T., Denier, N., Wallimann, M., Walther, S., Mertse, N., Breit, S., Federspiel, A., Wiest, R., & Soravia, L. (2022). Hippocampal volume and parahippocampal cingulum alterations are associated with avoidant attachment in patients with depression. Journal of Affective Disorders Reports, 10(100435). https://doi.org/10.1016/j.jadr.2022.100435

Bracht, T. et al. (2022) ‘Hippocampal volume and parahippocampal cingulum alterations are associated with avoidant attachment in patients with depression’, Journal of Affective Disorders Reports, 10(100435). Available at: https://doi.org/10.1016/j.jadr.2022.100435.

T. Bracht et al., “Hippocampal volume and parahippocampal cingulum alterations are associated with avoidant attachment in patients with depression,” Journal of Affective Disorders Reports, vol. 10, no. 100435, 2022, doi: 10.1016/j.jadr.2022.100435.

BRACHT, Tobias, Niklaus DENIER, Meret WALLIMANN, Sebastian WALTHER, Nicolas MERTSE, Sigrid BREIT, Andrea FEDERSPIEL, Roland WIEST und Leila SORAVIA, 2022. Hippocampal volume and parahippocampal cingulum alterations are associated with avoidant attachment in patients with depression. Journal of Affective Disorders Reports. 2022. Bd. 10, Nr. 100435. DOI 10.1016/j.jadr.2022.100435

Bracht, Tobias, Niklaus Denier, Meret Wallimann, Sebastian Walther, Nicolas Mertse, Sigrid Breit, Andrea Federspiel, Roland Wiest, and Leila Soravia. 2022. “Hippocampal Volume and Parahippocampal Cingulum Alterations Are Associated with Avoidant Attachment in Patients with Depression.” Journal of Affective Disorders Reports 10 (100435). https://doi.org/10.1016/j.jadr.2022.100435.

Bracht, Tobias, et al. “Hippocampal Volume and Parahippocampal Cingulum Alterations Are Associated with Avoidant Attachment in Patients with Depression.” Journal of Affective Disorders Reports, vol. 10, no. 100435, 2022, https://doi.org/10.1016/j.jadr.2022.100435.