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https://doi.org/10.21256/zhaw-29656| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | Hippocampal volume and parahippocampal cingulum alterations are associated with avoidant attachment in patients with depression |
| Autor/-in: | Bracht, Tobias Denier, Niklaus Wallimann, Meret Walther, Sebastian Mertse, Nicolas Breit, Sigrid Federspiel, Andrea Wiest, Roland Soravia, Leila |
| et. al: | No |
| DOI: | 10.1016/j.jadr.2022.100435 10.21256/zhaw-29656 |
| Erschienen in: | Journal of Affective Disorders Reports |
| Band(Heft): | 10 |
| Heft: | 100435 |
| Erscheinungsdatum: | 2022 |
| Verlag / Hrsg. Institution: | Elsevier |
| ISSN: | 2666-9153 |
| Sprache: | Englisch |
| Schlagwörter: | Depression; Attachment; Hippocampus; Cingulum; White matter; Diffusion tensor imaging |
| Fachgebiet (DDC): | 616.8: Neurologie und Krankheiten des Nervensystems |
| Zusammenfassung: | Background: Insecure attachment style (anxious and avoidant) predisposes to the development of depression and has been linked to hippocampal alterations in healthy individuals. However, it is unclear if there are alterations of the hippocampus and the parahippocampal cingulum (PHC) in patients with depression. Methods: Forty-eight patients with major depressive disorder and 18 healthy controls underwent MP2RAGE and diffusion-weighted magnetic resonance imaging. Attachment characteristics were assessed with the revised adult attachment scale. Patients were classified into subgroups with low (anxious: n = 27; avoidant: n = 21) and high (anxious: n = 20; avoidant: n = 28) attachment characteristics. Bilateral PHC were reconstructed using manual tractography. Hippocampal volumes, mean fractional anisotropy and mean diffusivity (MD) in bilateral PHC were compared between attachment subgroups and healthy controls. Results: Patients had higher scores of anxious and avoidant attachment, which were associated with depression severity. Patients with high avoidance had decreases in hippocampal volumes in comparison to patients with low avoidance. Furthermore, patients with high avoidance had increased MD in bilateral PHC in comparison to patients with low avoidance and in comparison to healthy controls. Limitations: Assessment of attachment characteristics may be influenced by cognitive biases due to depressive symptoms Conclusions: High attachment avoidance in patients with depression is associated with volume reductions in the hippocampus and impaired PHC-microstructure. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/29656 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | CC BY-NC-ND 4.0: Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International |
| Departement: | Soziale Arbeit |
| Organisationseinheit: | Institut für Kindheit, Jugend und Familie (IKJF) |
| Enthalten in den Sammlungen: | Publikationen Soziale Arbeit |
Dateien zu dieser Ressource:
| Datei | Beschreibung | Größe | Format | |
|---|---|---|---|---|
| 2022_Bracht-etal_Hippocampal-volume-parahippocampal-cingulum-alterations.pdf | 2.2 MB | Adobe PDF |  Öffnen/Anzeigen |
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Bracht, T., Denier, N., Wallimann, M., Walther, S., Mertse, N., Breit, S., Federspiel, A., Wiest, R., & Soravia, L. (2022). Hippocampal volume and parahippocampal cingulum alterations are associated with avoidant attachment in patients with depression. Journal of Affective Disorders Reports, 10(100435). https://doi.org/10.1016/j.jadr.2022.100435
Bracht, T. et al. (2022) ‘Hippocampal volume and parahippocampal cingulum alterations are associated with avoidant attachment in patients with depression’, Journal of Affective Disorders Reports, 10(100435). Available at: https://doi.org/10.1016/j.jadr.2022.100435.
T. Bracht et al., “Hippocampal volume and parahippocampal cingulum alterations are associated with avoidant attachment in patients with depression,” Journal of Affective Disorders Reports, vol. 10, no. 100435, 2022, doi: 10.1016/j.jadr.2022.100435.
BRACHT, Tobias, Niklaus DENIER, Meret WALLIMANN, Sebastian WALTHER, Nicolas MERTSE, Sigrid BREIT, Andrea FEDERSPIEL, Roland WIEST und Leila SORAVIA, 2022. Hippocampal volume and parahippocampal cingulum alterations are associated with avoidant attachment in patients with depression. Journal of Affective Disorders Reports. 2022. Bd. 10, Nr. 100435. DOI 10.1016/j.jadr.2022.100435
Bracht, Tobias, Niklaus Denier, Meret Wallimann, Sebastian Walther, Nicolas Mertse, Sigrid Breit, Andrea Federspiel, Roland Wiest, and Leila Soravia. 2022. “Hippocampal Volume and Parahippocampal Cingulum Alterations Are Associated with Avoidant Attachment in Patients with Depression.” Journal of Affective Disorders Reports 10 (100435). https://doi.org/10.1016/j.jadr.2022.100435.
Bracht, Tobias, et al. “Hippocampal Volume and Parahippocampal Cingulum Alterations Are Associated with Avoidant Attachment in Patients with Depression.” Journal of Affective Disorders Reports, vol. 10, no. 100435, 2022, https://doi.org/10.1016/j.jadr.2022.100435.
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