1. ZHAW digitalcollection
  2. Life Sciences und Facility Management
  3. Publikationen
  4. Publikationen Life Sciences und Facility Management
Full metadata record
DC FieldValueLanguage
dc.contributor.authorSilva Oliveira, Ana Gabriela-
dc.contributor.authorAndrade Rocha, Marina-
dc.contributor.authorSantos de Azevedo, Lucas-
dc.contributor.authorThaynara de Moura Coelho, Aline-
dc.contributor.authorRusso Chagas, Rafael César-
dc.contributor.authorBatista Santos, Hélio-
dc.contributor.authorGruppi Thomé, Ralph-
dc.contributor.authorPeter, Samuel-
dc.contributor.authorWolfram, Evelyn-
dc.contributor.authorKim, Bonglee-
dc.contributor.authorReis, Rui Manuel-
dc.contributor.authorde Azambuja Ribeiro, Rosy Iara Maciel-
dc.date.accessioned2024-01-19T10:34:15Z-
dc.date.available2024-01-19T10:34:15Z-
dc.date.issued2023-
dc.identifier.issn0032-0943de_CH
dc.identifier.issn1439-0221de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/29641-
dc.description.abstractGlioblastoma is the most frequent primary malignant brain tumor without effective treatment, which makes this work extremely relevant. The study of the bioactive compounds from medicinal plants plays an important role in the discovery of new drugs.This research investigated the constituents of Tapirira guianensis and its antitumor potential (in vitro and in vivo) in glioblastoma. The T. guianensis extracts were characterized by mass spectrometry. The ethyl acetate partition (01ID) and its fractions 01ID-F2 and 01ID-F4 from T. guianensis showed potential antitumor treatment evidenced by selective cytotoxicity for GAMG with IC50 14.1 µg/mL, 83.07 µg/mL, 59.27 µg/mL and U251 with IC50 25.92 µg/mL, 37.3 µg/mL and 18.84 µg/mL. Fractions 01ID-F2 and 01ID-F4 were 10 times more selective when compared to TMZ and 01ID for the two evaluated cell lines. T. guianensis also reduced matrix metalloproteinases 2 - 01ID-F2 (21.84%), 01ID-F4 (29.6%) and 9 - 01ID-F4 (73.42%), ID-F4 (53.84%) activities, and induced apoptosis mainly through the extrinsic pathway. Furthermore, all treatments significantly reduced tumor size (01ID p < 0,01, 01ID-F2 p < 0,01 and 01ID-F4 p < 0,0001) and caused blood vessels to shrink in vivo. The present findings highlight that T. guianensis exhibits considerable antitumor potential in preclinical studies of glioblastoma. This ability may be related to the phenolic compounds and sesquiterpene derivatives identified in the extracts. This study deserves further in vivo research, followed by clinical investigation.de_CH
dc.language.isoende_CH
dc.publisherThiemede_CH
dc.relation.ispartofPlanta Medicade_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectPlant extractde_CH
dc.subjectAngiogenesisde_CH
dc.subjectApoptosisde_CH
dc.subjectCell line, Tumorde_CH
dc.subjectGlioblastomade_CH
dc.subjectPlants, Medicinalde_CH
dc.subjectAntineoplastic agentde_CH
dc.subject.ddc615: Pharmakologie und Therapeutikde_CH
dc.titleTapirira guianensis is selectively cytotoxic, induces apoptosis to the glioblastoma and decreases tumor growth and angiogenesis in vivode_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
dc.identifier.doi10.1055/a-2181-2569de_CH
dc.identifier.pmid37832581de_CH
zhaw.funding.euNode_CH
zhaw.issue1de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end24de_CH
zhaw.pages.start13de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume90de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.webfeedPhytopharmaziede_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
Appears in collections:Publikationen Life Sciences und Facility Management

Files in This Item:
There are no files associated with this item.
Show simple item record
Silva Oliveira, A. G., Andrade Rocha, M., Santos de Azevedo, L., Thaynara de Moura Coelho, A., Russo Chagas, R. C., Batista Santos, H., Gruppi Thomé, R., Peter, S., Wolfram, E., Kim, B., Reis, R. M., & de Azambuja Ribeiro, R. I. M. (2023). Tapirira guianensis is selectively cytotoxic, induces apoptosis to the glioblastoma and decreases tumor growth and angiogenesis in vivo. Planta Medica, 90(1), 13–24. https://doi.org/10.1055/a-2181-2569
Silva Oliveira, A.G. et al. (2023) ‘Tapirira guianensis is selectively cytotoxic, induces apoptosis to the glioblastoma and decreases tumor growth and angiogenesis in vivo’, Planta Medica, 90(1), pp. 13–24. Available at: https://doi.org/10.1055/a-2181-2569.
A. G. Silva Oliveira et al., “Tapirira guianensis is selectively cytotoxic, induces apoptosis to the glioblastoma and decreases tumor growth and angiogenesis in vivo,” Planta Medica, vol. 90, no. 1, pp. 13–24, 2023, doi: 10.1055/a-2181-2569.
SILVA OLIVEIRA, Ana Gabriela, Marina ANDRADE ROCHA, Lucas SANTOS DE AZEVEDO, Aline THAYNARA DE MOURA COELHO, Rafael César RUSSO CHAGAS, Hélio BATISTA SANTOS, Ralph GRUPPI THOMÉ, Samuel PETER, Evelyn WOLFRAM, Bonglee KIM, Rui Manuel REIS und Rosy Iara Maciel DE AZAMBUJA RIBEIRO, 2023. Tapirira guianensis is selectively cytotoxic, induces apoptosis to the glioblastoma and decreases tumor growth and angiogenesis in vivo. Planta Medica. 2023. Bd. 90, Nr. 1, S. 13–24. DOI 10.1055/a-2181-2569
Silva Oliveira, Ana Gabriela, Marina Andrade Rocha, Lucas Santos de Azevedo, Aline Thaynara de Moura Coelho, Rafael César Russo Chagas, Hélio Batista Santos, Ralph Gruppi Thomé, et al. 2023. “Tapirira Guianensis Is Selectively Cytotoxic, Induces Apoptosis to the Glioblastoma and Decreases Tumor Growth and Angiogenesis in Vivo.” Planta Medica 90 (1): 13–24. https://doi.org/10.1055/a-2181-2569.
Silva Oliveira, Ana Gabriela, et al. “Tapirira Guianensis Is Selectively Cytotoxic, Induces Apoptosis to the Glioblastoma and Decreases Tumor Growth and Angiogenesis in Vivo.” Planta Medica, vol. 90, no. 1, 2023, pp. 13–24, https://doi.org/10.1055/a-2181-2569.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.