| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | Tapirira guianensis is selectively cytotoxic, induces apoptosis to the glioblastoma and decreases tumor growth and angiogenesis in vivo |
| Autor/-in: | Silva Oliveira, Ana Gabriela Andrade Rocha, Marina Santos de Azevedo, Lucas Thaynara de Moura Coelho, Aline Russo Chagas, Rafael César Batista Santos, Hélio Gruppi Thomé, Ralph Peter, Samuel Wolfram, Evelyn Kim, Bonglee Reis, Rui Manuel de Azambuja Ribeiro, Rosy Iara Maciel |
| et. al: | No |
| DOI: | 10.1055/a-2181-2569 |
| Erschienen in: | Planta Medica |
| Band(Heft): | 90 |
| Heft: | 1 |
| Seite(n): | 13 |
| Seiten bis: | 24 |
| Erscheinungsdatum: | 2023 |
| Verlag / Hrsg. Institution: | Thieme |
| ISSN: | 0032-0943 1439-0221 |
| Sprache: | Englisch |
| Schlagwörter: | Plant extract; Angiogenesis; Apoptosis; Cell line, Tumor; Glioblastoma; Plants, Medicinal; Antineoplastic agent |
| Fachgebiet (DDC): | 615: Pharmakologie und Therapeutik |
| Zusammenfassung: | Glioblastoma is the most frequent primary malignant brain tumor without effective treatment, which makes this work extremely relevant. The study of the bioactive compounds from medicinal plants plays an important role in the discovery of new drugs.This research investigated the constituents of Tapirira guianensis and its antitumor potential (in vitro and in vivo) in glioblastoma. The T. guianensis extracts were characterized by mass spectrometry. The ethyl acetate partition (01ID) and its fractions 01ID-F2 and 01ID-F4 from T. guianensis showed potential antitumor treatment evidenced by selective cytotoxicity for GAMG with IC50 14.1 µg/mL, 83.07 µg/mL, 59.27 µg/mL and U251 with IC50 25.92 µg/mL, 37.3 µg/mL and 18.84 µg/mL. Fractions 01ID-F2 and 01ID-F4 were 10 times more selective when compared to TMZ and 01ID for the two evaluated cell lines. T. guianensis also reduced matrix metalloproteinases 2 - 01ID-F2 (21.84%), 01ID-F4 (29.6%) and 9 - 01ID-F4 (73.42%), ID-F4 (53.84%) activities, and induced apoptosis mainly through the extrinsic pathway. Furthermore, all treatments significantly reduced tumor size (01ID p < 0,01, 01ID-F2 p < 0,01 and 01ID-F4 p < 0,0001) and caused blood vessels to shrink in vivo. The present findings highlight that T. guianensis exhibits considerable antitumor potential in preclinical studies of glioblastoma. This ability may be related to the phenolic compounds and sesquiterpene derivatives identified in the extracts. This study deserves further in vivo research, followed by clinical investigation. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/29641 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | Lizenz gemäss Verlagsvertrag |
| Departement: | Life Sciences und Facility Management |
| Organisationseinheit: | Institut für Chemie und Biotechnologie (ICBT) |
| Enthalten in den Sammlungen: | Publikationen Life Sciences und Facility Management |
Dateien zu dieser Ressource:
Es gibt keine Dateien zu dieser Ressource.
Zur Langanzeige
Silva Oliveira, A. G., Andrade Rocha, M., Santos de Azevedo, L., Thaynara de Moura Coelho, A., Russo Chagas, R. C., Batista Santos, H., Gruppi Thomé, R., Peter, S., Wolfram, E., Kim, B., Reis, R. M., & de Azambuja Ribeiro, R. I. M. (2023). Tapirira guianensis is selectively cytotoxic, induces apoptosis to the glioblastoma and decreases tumor growth and angiogenesis in vivo. Planta Medica, 90(1), 13–24. https://doi.org/10.1055/a-2181-2569
Silva Oliveira, A.G. et al. (2023) ‘Tapirira guianensis is selectively cytotoxic, induces apoptosis to the glioblastoma and decreases tumor growth and angiogenesis in vivo’, Planta Medica, 90(1), pp. 13–24. Available at: https://doi.org/10.1055/a-2181-2569.
A. G. Silva Oliveira et al., “Tapirira guianensis is selectively cytotoxic, induces apoptosis to the glioblastoma and decreases tumor growth and angiogenesis in vivo,” Planta Medica, vol. 90, no. 1, pp. 13–24, 2023, doi: 10.1055/a-2181-2569.
SILVA OLIVEIRA, Ana Gabriela, Marina ANDRADE ROCHA, Lucas SANTOS DE AZEVEDO, Aline THAYNARA DE MOURA COELHO, Rafael César RUSSO CHAGAS, Hélio BATISTA SANTOS, Ralph GRUPPI THOMÉ, Samuel PETER, Evelyn WOLFRAM, Bonglee KIM, Rui Manuel REIS und Rosy Iara Maciel DE AZAMBUJA RIBEIRO, 2023. Tapirira guianensis is selectively cytotoxic, induces apoptosis to the glioblastoma and decreases tumor growth and angiogenesis in vivo. Planta Medica. 2023. Bd. 90, Nr. 1, S. 13–24. DOI 10.1055/a-2181-2569
Silva Oliveira, Ana Gabriela, Marina Andrade Rocha, Lucas Santos de Azevedo, Aline Thaynara de Moura Coelho, Rafael César Russo Chagas, Hélio Batista Santos, Ralph Gruppi Thomé, et al. 2023. “Tapirira Guianensis Is Selectively Cytotoxic, Induces Apoptosis to the Glioblastoma and Decreases Tumor Growth and Angiogenesis in Vivo.” Planta Medica 90 (1): 13–24. https://doi.org/10.1055/a-2181-2569.
Silva Oliveira, Ana Gabriela, et al. “Tapirira Guianensis Is Selectively Cytotoxic, Induces Apoptosis to the Glioblastoma and Decreases Tumor Growth and Angiogenesis in Vivo.” Planta Medica, vol. 90, no. 1, 2023, pp. 13–24, https://doi.org/10.1055/a-2181-2569.
Alle Ressourcen in diesem Repository sind urheberrechtlich geschützt, soweit nicht anderweitig angezeigt.