Computational fluid dynamics for advanced characterisation of bioreactors used in the biopharmaceutical industry : part I: literature review

Seidel, Stefan; Schirmer, Cedric; Maschke, Rüdiger; Rossi, Lia; Eibl-Schindler, Regine; Eibl, Dieter

doi:10.5772/intechopen.109848

Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-29536

Publication type:	Book part
Type of review:	Peer review (publication)
Title:	Computational fluid dynamics for advanced characterisation of bioreactors used in the biopharmaceutical industry : part I: literature review
Authors:	Seidel, Stefan Schirmer, Cedric Maschke, Rüdiger Rossi, Lia Eibl-Schindler, Regine Eibl, Dieter
et. al:	No
DOI:	10.5772/intechopen.109848 10.21256/zhaw-29536
Published in:	Computational Fluid Dynamics - Recent Advances, New Perspectives and Applications
Editors of the parent work:	Ji, Guozhao Dong, Jingliang
Page(s):	53
Pages to:	82
Issue Date:	14-Feb-2023
Publisher / Ed. Institution:	IntechOpen Limited
Publisher / Ed. Institution:	London
ISBN:	978-1-80355-654-3 978-1-80355-655-0
Language:	English
Subjects:	Mixing time; Oxygen mass transfer; Power input; Process engineering characterisation; Single-use bioreactor; Validation; Verfahrenstechnik
Subject (DDC):	660: Chemical engineering
Abstract:	Computational fluid dynamics (CFD) is a widely used tool for investigating fluid flows in bioreactors. It has been used in the biopharmaceutical industry for years and has established itself as an important tool for process engineering characterisation. As a result, CFD simulations are increasingly being used to complement classical process engineering investigations in the laboratory with spatially and temporally resolved results, or even replace them when laboratory investigations are not possible. Parameters that can be determined include the specific power input, Kolmogorov length, hydrodynamic stress, mixing time, oxygen transfer rate, and for cultivations with microcarriers, the NS1 criterion. In the first part of this series, a literature review illustrates how these parameters can be determined using CFD and how they can be validated experimentally. In addition, an overview of the hardware and software typically used for bioreactor characterisation will also be provided, including process engineering parameter investigations from the literature. In the second part of this series, the authors’ research results will be used to show how the process engineering characterisation of mechanically driven bioreactors for the biopharmaceutical industry (stirred, orbitally shaken, and wave-mixed) can be determined and validated using CFD.
URI:	https://digitalcollection.zhaw.ch/handle/11475/29536
Fulltext version:	Published version
License (according to publishing contract):	CC BY 3.0: Attribution 3.0 Unported
Departement:	Life Sciences and Facility Management
Organisational Unit:	Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:	Publikationen Life Sciences und Facility Management

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Seidel, S., Schirmer, C., Maschke, R., Rossi, L., Eibl-Schindler, R., & Eibl, D. (2023). Computational fluid dynamics for advanced characterisation of bioreactors used in the biopharmaceutical industry : part I: literature review. In G. Ji & J. Dong (Eds.), Computational Fluid Dynamics - Recent Advances, New Perspectives and Applications (pp. 53–82). IntechOpen Limited. https://doi.org/10.5772/intechopen.109848

Seidel, S. et al. (2023) ‘Computational fluid dynamics for advanced characterisation of bioreactors used in the biopharmaceutical industry : part I: literature review’, in G. Ji and J. Dong (eds) Computational Fluid Dynamics - Recent Advances, New Perspectives and Applications. London: IntechOpen Limited, pp. 53–82. Available at: https://doi.org/10.5772/intechopen.109848.

S. Seidel, C. Schirmer, R. Maschke, L. Rossi, R. Eibl-Schindler, and D. Eibl, “Computational fluid dynamics for advanced characterisation of bioreactors used in the biopharmaceutical industry : part I: literature review,” in Computational Fluid Dynamics - Recent Advances, New Perspectives and Applications, G. Ji and J. Dong, Eds. London: IntechOpen Limited, 2023, pp. 53–82. doi: 10.5772/intechopen.109848.

SEIDEL, Stefan, Cedric SCHIRMER, Rüdiger MASCHKE, Lia ROSSI, Regine EIBL-SCHINDLER und Dieter EIBL, 2023. Computational fluid dynamics for advanced characterisation of bioreactors used in the biopharmaceutical industry : part I: literature review. In: Guozhao JI und Jingliang DONG (Hrsg.), Computational Fluid Dynamics - Recent Advances, New Perspectives and Applications. London: IntechOpen Limited. S. 53–82. ISBN 978-1-80355-654-3

Seidel, Stefan, Cedric Schirmer, Rüdiger Maschke, Lia Rossi, Regine Eibl-Schindler, and Dieter Eibl. 2023. “Computational Fluid Dynamics for Advanced Characterisation of Bioreactors Used in the Biopharmaceutical Industry : Part I: Literature Review.” In Computational Fluid Dynamics - Recent Advances, New Perspectives and Applications, edited by Guozhao Ji and Jingliang Dong, 53–82. London: IntechOpen Limited. https://doi.org/10.5772/intechopen.109848.

Seidel, Stefan, et al. “Computational Fluid Dynamics for Advanced Characterisation of Bioreactors Used in the Biopharmaceutical Industry : Part I: Literature Review.” Computational Fluid Dynamics - Recent Advances, New Perspectives and Applications, edited by Guozhao Ji and Jingliang Dong, IntechOpen Limited, 2023, pp. 53–82, https://doi.org/10.5772/intechopen.109848.