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https://doi.org/10.21256/zhaw-29531| Publication type: | Book part |
| Type of review: | Peer review (publication) |
| Title: | Computational fluid dynamics for advanced characterisation of bioreactors used in the biopharmaceutical industry : part II: case studies |
| Authors: | Seidel, Stefan Schirmer, Cedric Maschke, Rüdiger Rossi, Lia Eibl-Schindler, Regine Eibl, Dieter |
| et. al: | No |
| DOI: | 10.5772/intechopen.109849 10.21256/zhaw-29531 |
| Published in: | Computational Fluid Dynamics - Recent Advances, New Perspectives and Applications |
| Editors of the parent work: | Ji, Guozhao Dong, Jingliang |
| Page(s): | 83 |
| Pages to: | 98 |
| Issue Date: | 12-Feb-2023 |
| Publisher / Ed. Institution: | IntechOpen Limited |
| Publisher / Ed. Institution: | London |
| ISBN: | 978-1-80355-654-3 978-1-80355-655-0 |
| Language: | English |
| Subjects: | Hydrodynamic stress; Orbitally shaken bioreactor; Particle image velocimetry; Power input; Process engineering characterisation; Stirred tank reactor; Wave-mixed bioreactor; Verfahrenstechnik |
| Subject (DDC): | 660: Chemical engineering |
| Abstract: | The first part of this series on characterisation of bioreactors in the biopharmaceutical industry using computational fluid dynamics presented a literature review to illustrate how characterisation can be performed and which process engineering parameters can be determined using computational fluid dynamics (CFD). In addition, experimental validation methods were presented, and an overview of typical hardware and software was also provided. In this second part, a selection of the authors’ research results will be used to demonstrate how the process characterisation of mechanically driven bioreactors for the biopharmaceutical industry can be determined with CFD and then experimentally validated. Three stirred tank bioreactors with different filling volumes and stirrers were used to demonstrate power input and oxygen transfer in single- and two-phase simulations. For wave-mixed and orbitally shaken systems, the fluid flow was transiently simulated and experimentally validated. In addition, the power input was also determined for both systems. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/29531 |
| Fulltext version: | Published version |
| License (according to publishing contract): | CC BY 3.0: Attribution 3.0 Unported |
| Departement: | Life Sciences and Facility Management |
| Organisational Unit: | Institute of Chemistry and Biotechnology (ICBT) |
| Appears in collections: | Publikationen Life Sciences und Facility Management |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 2023_Seidel-etal_CFD-Bioreactors-PartII-Case-Studies_IntechOpen.pdf | 2.94 MB | Adobe PDF |  View/Open |
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Seidel, S., Schirmer, C., Maschke, R., Rossi, L., Eibl-Schindler, R., & Eibl, D. (2023). Computational fluid dynamics for advanced characterisation of bioreactors used in the biopharmaceutical industry : part II: case studies. In G. Ji & J. Dong (Eds.), Computational Fluid Dynamics - Recent Advances, New Perspectives and Applications (pp. 83–98). IntechOpen Limited. https://doi.org/10.5772/intechopen.109849
Seidel, S. et al. (2023) ‘Computational fluid dynamics for advanced characterisation of bioreactors used in the biopharmaceutical industry : part II: case studies’, in G. Ji and J. Dong (eds) Computational Fluid Dynamics - Recent Advances, New Perspectives and Applications. London: IntechOpen Limited, pp. 83–98. Available at: https://doi.org/10.5772/intechopen.109849.
S. Seidel, C. Schirmer, R. Maschke, L. Rossi, R. Eibl-Schindler, and D. Eibl, “Computational fluid dynamics for advanced characterisation of bioreactors used in the biopharmaceutical industry : part II: case studies,” in Computational Fluid Dynamics - Recent Advances, New Perspectives and Applications, G. Ji and J. Dong, Eds. London: IntechOpen Limited, 2023, pp. 83–98. doi: 10.5772/intechopen.109849.
SEIDEL, Stefan, Cedric SCHIRMER, Rüdiger MASCHKE, Lia ROSSI, Regine EIBL-SCHINDLER und Dieter EIBL, 2023. Computational fluid dynamics for advanced characterisation of bioreactors used in the biopharmaceutical industry : part II: case studies. In: Guozhao JI und Jingliang DONG (Hrsg.), Computational Fluid Dynamics - Recent Advances, New Perspectives and Applications. London: IntechOpen Limited. S. 83–98. ISBN 978-1-80355-654-3
Seidel, Stefan, Cedric Schirmer, Rüdiger Maschke, Lia Rossi, Regine Eibl-Schindler, and Dieter Eibl. 2023. “Computational Fluid Dynamics for Advanced Characterisation of Bioreactors Used in the Biopharmaceutical Industry : Part II: Case Studies.” In Computational Fluid Dynamics - Recent Advances, New Perspectives and Applications, edited by Guozhao Ji and Jingliang Dong, 83–98. London: IntechOpen Limited. https://doi.org/10.5772/intechopen.109849.
Seidel, Stefan, et al. “Computational Fluid Dynamics for Advanced Characterisation of Bioreactors Used in the Biopharmaceutical Industry : Part II: Case Studies.” Computational Fluid Dynamics - Recent Advances, New Perspectives and Applications, edited by Guozhao Ji and Jingliang Dong, IntechOpen Limited, 2023, pp. 83–98, https://doi.org/10.5772/intechopen.109849.
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