Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-29274
Publication type: Article in scientific journal
Type of review: Peer review (publication)
Title: Antidepressants use in Italy : an ecological study of national and regional trends and associated factors
Authors: Amendola, Simone
Hengartner, Michael Pascal
et. al: No
DOI: 10.1097/YIC.0000000000000522
10.21256/zhaw-29274
Published in: International Clinical Psychopharmacology
Volume(Issue): 32
Issue: 2
Page(s): 93
Pages to: 105
Issue Date: 15-Nov-2023
Publisher / Ed. Institution: Wolters Kluwer
ISSN: 0268-1315
1473-5857
Language: English
Subjects: Depression; Medication; Pharmacoepidemiology; Psychotropic drug; Variation
Subject (DDC): 615: Pharmacology and therapeutics
616.8: Neurology, diseases of nervous system
Abstract: The present study aimed to (1) provide an update on trends in AD consumption both at the national and regional unit of analysis for the period 2000-2020 in Italy and (2) analyze sociodemographic and healthcare system-related factors associated with AD prescribing at the regional-population level between 2000 and 2019. Data were extracted from reports of the Italian Medicines Agency and databases of the Italian National Institute of Statistics. Linear regression and mixed models were applied to analyze trends in AD use (DDD/1000/day) and ecological factors associated with AD prescribing. Between 2000 and 2010 AD prescription rates constantly increased. Thereafter they stabilized until 2017 when a positive trend began again. There was a positive ecological association between AD prescribing and rates of hospital discharge due to affective disorders, antibiotics prescribing, public non-drug healthcare spending per capita, and Northern regions compared to Southern regions. AD consumption increased massively during the 2000s, flattened during the 2010s but thereafter increased again until 2020. The ecological correlation between healthcare provision/spending and AD consumption suggests that health-economic factors may play an important role.
URI: https://digitalcollection.zhaw.ch/handle/11475/29274
Fulltext version: Accepted version
License (according to publishing contract): Licence according to publishing contract
Restricted until: 2024-11-15
Departement: Applied Psychology
Organisational Unit: Psychological Institute (PI)
Appears in collections:Publikationen Angewandte Psychologie

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Amendola, S., & Hengartner, M. P. (2023). Antidepressants use in Italy : an ecological study of national and regional trends and associated factors. International Clinical Psychopharmacology, 32(2), 93–105. https://doi.org/10.1097/YIC.0000000000000522
Amendola, S. and Hengartner, M.P. (2023) ‘Antidepressants use in Italy : an ecological study of national and regional trends and associated factors’, International Clinical Psychopharmacology, 32(2), pp. 93–105. Available at: https://doi.org/10.1097/YIC.0000000000000522.
S. Amendola and M. P. Hengartner, “Antidepressants use in Italy : an ecological study of national and regional trends and associated factors,” International Clinical Psychopharmacology, vol. 32, no. 2, pp. 93–105, Nov. 2023, doi: 10.1097/YIC.0000000000000522.
AMENDOLA, Simone und Michael Pascal HENGARTNER, 2023. Antidepressants use in Italy : an ecological study of national and regional trends and associated factors. International Clinical Psychopharmacology. 15 November 2023. Bd. 32, Nr. 2, S. 93–105. DOI 10.1097/YIC.0000000000000522
Amendola, Simone, and Michael Pascal Hengartner. 2023. “Antidepressants Use in Italy : An Ecological Study of National and Regional Trends and Associated Factors.” International Clinical Psychopharmacology 32 (2): 93–105. https://doi.org/10.1097/YIC.0000000000000522.
Amendola, Simone, and Michael Pascal Hengartner. “Antidepressants Use in Italy : An Ecological Study of National and Regional Trends and Associated Factors.” International Clinical Psychopharmacology, vol. 32, no. 2, Nov. 2023, pp. 93–105, https://doi.org/10.1097/YIC.0000000000000522.


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