Title: Pseudouridimycin : the first nucleoside analogue that selectively inhibits bacterial RNA polymerase
Authors : Chellat, Mathieu F.
Riedl, Rainer
Published in : Angewandte Chemie : international Edition
Volume(Issue) : 56
Issue : 43
Pages : 13184
Pages to: 13186
Publisher / Ed. Institution : Wiley
Issue Date: 2017
Language : Englisch / English
Subjects : RNA polymerase; Antibiotics; Medicinal chemistry; Natural products; Nucleoside analogues
Subject (DDC) : 615: Pharmakologie und Therapeutik
Abstract: Seek, and ye shall find: After years of focusing research on synthetic antibiotics out of fear that all the useful natural ones had already been found, a novel antibacterial compound has been discovered through conventional microbial extract screening. The broad-spectrum nucleoside-analogue inhibitor pseudouridimycin is selective for bacterial RNA polymerase and elicits very low resistance rates.
Departement: Life Sciences und Facility Management
Publication type: Beitrag in wissenschaftlicher Zeitschrift / Article in scientific Journal
Type of review: Peer review (Publikation)
DOI : 10.1002/anie.201708133
ISSN: 1433-7851
PMID : 28895263
URI: https://digitalcollection.zhaw.ch/handle/11475/2881
License (according to publishing contract) : Lizenz gemäss Verlagsvertrag / Licence according to publishing contract
Appears in Collections:Publikationen Life Sciences und Facility Management

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