Publication type: Article in scientific journal
Type of review: Peer review (publication)
Title: Pseudouridimycin : the first nucleoside analogue that selectively inhibits bacterial RNA polymerase
Authors: Chellat, Mathieu F.
Riedl, Rainer
DOI: 10.1002/anie.201708133
Published in: Angewandte Chemie: International Edition
Volume(Issue): 56
Issue: 43
Pages: 13184
Pages to: 13186
Issue Date: 2017
Publisher / Ed. Institution: Wiley
ISSN: 1433-7851
Language: English
Subjects: RNA polymerase; Antibiotics; Medicinal chemistry; Natural products; Nucleoside analogues
Subject (DDC): 615: Pharmacology and therapeutics
Abstract: Seek, and ye shall find: After years of focusing research on synthetic antibiotics out of fear that all the useful natural ones had already been found, a novel antibacterial compound has been discovered through conventional microbial extract screening. The broad-spectrum nucleoside-analogue inhibitor pseudouridimycin is selective for bacterial RNA polymerase and elicits very low resistance rates.
Fulltext version: Published version
License (according to publishing contract): Licence according to publishing contract
Departement: Life Sciences and Facility Management
Appears in Collections:Publikationen Life Sciences und Facility Management

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