Title: Pseudouridimycin : the first nucleoside analogue that selectively inhibits bacterial RNA polymerase
Authors : Chellat, Mathieu F.
Riedl, Rainer
Published in : Angewandte Chemie : international Edition
Volume(Issue) : 56
Issue : 43
Pages : 13184
Pages to: 13186
Publisher / Ed. Institution : Wiley
Issue Date: 2017
License (according to publishing contract) : Licence according to publishing contract
Type of review: Peer review (Publication)
Language : English
Subjects : RNA polymerase; Antibiotics; Medicinal chemistry; Natural products; Nucleoside analogues
Subject (DDC) : 615: Pharmacology and therapeutics
Abstract: Seek, and ye shall find: After years of focusing research on synthetic antibiotics out of fear that all the useful natural ones had already been found, a novel antibacterial compound has been discovered through conventional microbial extract screening. The broad-spectrum nucleoside-analogue inhibitor pseudouridimycin is selective for bacterial RNA polymerase and elicits very low resistance rates.
Departement: Life Sciences und Facility Management
Publication type: Article in scientific Journal
DOI : 10.1002/anie.201708133
ISSN: 1433-7851
URI: https://digitalcollection.zhaw.ch/handle/11475/2881
Appears in Collections:Publikationen Life Sciences und Facility Management

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