|Publication type:||Article in scientific journal|
|Type of review:||Peer review (publication)|
|Title:||Pseudouridimycin : the first nucleoside analogue that selectively inhibits bacterial RNA polymerase|
|Authors:||Chellat, Mathieu F.|
|Published in:||Angewandte Chemie: International Edition|
|Publisher / Ed. Institution:||Wiley|
|Subjects:||RNA polymerase; Antibiotics; Medicinal chemistry; Natural products; Nucleoside analogues|
|Subject (DDC):||615: Pharmacology and therapeutics|
|Abstract:||Seek, and ye shall find: After years of focusing research on synthetic antibiotics out of fear that all the useful natural ones had already been found, a novel antibacterial compound has been discovered through conventional microbial extract screening. The broad-spectrum nucleoside-analogue inhibitor pseudouridimycin is selective for bacterial RNA polymerase and elicits very low resistance rates.|
|Fulltext version:||Published version|
|License (according to publishing contract):||Licence according to publishing contract|
|Departement:||Life Sciences and Facility Management|
|Appears in Collections:||Publikationen Life Sciences und Facility Management|
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