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https://doi.org/10.21256/zhaw-1686| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | Strategic targeting of multiple water-mediated interactions : a concise and rational structure-based design approach to potent and selective MMP-13 inhibitors |
| Autor/-in: | Fischer, Thomas Riedl, Rainer |
| DOI: | 10.1002/cmdc.201300278 10.21256/zhaw-1686 |
| Erschienen in: | ChemMedChem |
| Band(Heft): | 8 |
| Heft: | 9 |
| Seite(n): | 1457 |
| Seiten bis: | 1461 |
| Erscheinungsdatum: | 2013 |
| Verlag / Hrsg. Institution: | Wiley |
| ISSN: | 1860-7187 1860-7179 |
| Sprache: | Englisch |
| Schlagwörter: | Water-mediated interactions; Medicinal chemistry; Chemical biology; Structure-based design |
| Fachgebiet (DDC): | 572: Biochemie |
| Zusammenfassung: | Water in the architecture of life: Potent and selective matrix metalloproteinase-13 (MMP-13) inhibitors were rationally designed by targeting multiple water-mediated interactions between the target protein and small-molecule inhibitors. This structure-based design concept offers tremendous opportunities for the discovery of unique small molecules with tailored biological activity. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/2865 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | CC BY-NC 3.0: Namensnennung - Nicht kommerziell 3.0 Unported |
| Departement: | Life Sciences und Facility Management |
| Organisationseinheit: | Institut für Chemie und Biotechnologie (ICBT) |
| Enthalten in den Sammlungen: | Publikationen Life Sciences und Facility Management |
Dateien zu dieser Ressource:
| Datei | Beschreibung | Größe | Format | |
|---|---|---|---|---|
| 2013_Fischer_Strategic targeting of multiple water-mediated interactions_ChemMedChem.pdf | 1.29 MB | Adobe PDF |  Öffnen/Anzeigen |
Zur Langanzeige
Fischer, T., & Riedl, R. (2013). Strategic targeting of multiple water-mediated interactions : a concise and rational structure-based design approach to potent and selective MMP-13 inhibitors. ChemMedChem, 8(9), 1457–1461. https://doi.org/10.1002/cmdc.201300278
Fischer, T. and Riedl, R. (2013) ‘Strategic targeting of multiple water-mediated interactions : a concise and rational structure-based design approach to potent and selective MMP-13 inhibitors’, ChemMedChem, 8(9), pp. 1457–1461. Available at: https://doi.org/10.1002/cmdc.201300278.
T. Fischer and R. Riedl, “Strategic targeting of multiple water-mediated interactions : a concise and rational structure-based design approach to potent and selective MMP-13 inhibitors,” ChemMedChem, vol. 8, no. 9, pp. 1457–1461, 2013, doi: 10.1002/cmdc.201300278.
FISCHER, Thomas und Rainer RIEDL, 2013. Strategic targeting of multiple water-mediated interactions : a concise and rational structure-based design approach to potent and selective MMP-13 inhibitors. ChemMedChem. 2013. Bd. 8, Nr. 9, S. 1457–1461. DOI 10.1002/cmdc.201300278
Fischer, Thomas, and Rainer Riedl. 2013. “Strategic Targeting of Multiple Water-Mediated Interactions : A Concise and Rational Structure-Based Design Approach to Potent and Selective MMP-13 Inhibitors.” ChemMedChem 8 (9): 1457–61. https://doi.org/10.1002/cmdc.201300278.
Fischer, Thomas, and Rainer Riedl. “Strategic Targeting of Multiple Water-Mediated Interactions : A Concise and Rational Structure-Based Design Approach to Potent and Selective MMP-13 Inhibitors.” ChemMedChem, vol. 8, no. 9, 2013, pp. 1457–61, https://doi.org/10.1002/cmdc.201300278.
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