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Title: Strategic targeting of multiple water-mediated interactions : a concise and rational structure-based design approach to potent and selective MMP-13 inhibitors
Authors : Fischer, Thomas
Riedl, Rainer
Published in : ChemMedChem
Volume(Issue) : 8
Issue : 9
Pages : 1457
Pages to: 1461
Publisher / Ed. Institution : Wiley
Issue Date: 2013
Language : Englisch / English
Subjects : Water-mediated interactions; Medicinal chemistry; Chemical biology; Structure-based design
Subject (DDC) : 572: Biochemie
Abstract: Water in the architecture of life: Potent and selective matrix metalloproteinase-13 (MMP-13) inhibitors were rationally designed by targeting multiple water-mediated interactions between the target protein and small-molecule inhibitors. This structure-based design concept offers tremendous opportunities for the discovery of unique small molecules with tailored biological activity.
Departement: Life Sciences und Facility Management
Organisational Unit: Institut für Chemie und Biotechnologie (ICBT)
Publication type: Beitrag in wissenschaftlicher Zeitschrift / Article in scientific Journal
Type of review: Keine Angabe / Not specified
DOI : 10.1002/cmdc.201300278
ISSN: 1860-7179
License (according to publishing contract) : CC BY-NC 3.0: Namensnennung - Nicht kommerziell 3.0 Unported
Appears in Collections:Publikationen Life Sciences und Facility Management

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