Somatosensory and psychological phenotypes associated with neuropathic pain in entrapment neuropathy

Matesanz, Luis; Hausheer, Andrea C.; Baskozos, Georgios; Bennett, David L. H.; Schmid, Annina B.

doi:10.1097/j.pain.0000000000002102

Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-28382

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Somatosensory and psychological phenotypes associated with neuropathic pain in entrapment neuropathy
Authors:	Matesanz, Luis Hausheer, Andrea C. Baskozos, Georgios Bennett, David L. H. Schmid, Annina B.
et. al:	No
DOI:	10.1097/j.pain.0000000000002102 10.21256/zhaw-28382
Published in:	Pain
Volume(Issue):	162
Issue:	4
Page(s):	1211
Pages to:	1220
Issue Date:	Apr-2021
Publisher / Ed. Institution:	Lippincott Williams & Wilkins
ISSN:	0304-3959 1872-6623
Language:	English
Subjects:	Cross-sectional studies; Phenotype; Nerve compression syndrome; Neuralgia; Neuropathic pain; Quantitative sensory testing; Entrapment neuropathy; Carpal tunnel syndrome
Subject (DDC):	616.8: Neurology, diseases of nervous system
Abstract:	It currently remains unclear why some patients with entrapment neuropathies develop neuropathic pain (neuP), whereas others have non-neuP, presumably of nociceptive character. Studying patients with carpal tunnel syndrome (CTS), this cross-sectional cohort study investigated changes in somatosensory structure and function as well as emotional well-being specific to the presence and severity of neuP. Patients with CTS (n = 108) were subgrouped by the DN4 questionnaire into those without and with neuP. The latter group was further subdivided into mild and moderate/severe neuP using a pain visual analogue scale. N = 32 participants served as healthy controls. All participants underwent a clinical examination, quantitative sensory testing, electrodiagnostic testing (EDT), and skin biopsy to determine the structural integrity of dermal and intraepidermal nerve fibres. Patients also completed questionnaires evaluating symptom severity and functional deficits, pain distribution, sleep quality, and emotional well-being. The overall prevalence of neuP in patients with CTS was 80%, of which 63% had mild neuP. Symptom severity and functional deficits as well as somatosensory dysfunction was more pronounced with the presence and increasing severity of neuP. No difference was identified among patient groups for EDT and nerve fibre integrity on biopsies. The severity of neuP was accompanied by more pronounced deficits in emotional well-being and sleep quality. Intriguingly, extraterritorial spread of symptoms was more prevalent in patients with moderate/severe neuP, indicating the presence of central mechanisms. NeuP is common in patients with CTS, and its severity is related to the extent of somatosensory dysfunction and a compromise of emotional well-being.
URI:	https://digitalcollection.zhaw.ch/handle/11475/28382
Fulltext version:	Published version
License (according to publishing contract):	CC BY 4.0: Attribution 4.0 International
Departement:	School of Health Sciences
Organisational Unit:	Institute of Physiotherapy (IPT)
Appears in collections:	Publikationen Gesundheit

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Matesanz, L., Hausheer, A. C., Baskozos, G., Bennett, D. L. H., & Schmid, A. B. (2021). Somatosensory and psychological phenotypes associated with neuropathic pain in entrapment neuropathy. Pain, 162(4), 1211–1220. https://doi.org/10.1097/j.pain.0000000000002102

Matesanz, L. et al. (2021) ‘Somatosensory and psychological phenotypes associated with neuropathic pain in entrapment neuropathy’, Pain, 162(4), pp. 1211–1220. Available at: https://doi.org/10.1097/j.pain.0000000000002102.

L. Matesanz, A. C. Hausheer, G. Baskozos, D. L. H. Bennett, and A. B. Schmid, “Somatosensory and psychological phenotypes associated with neuropathic pain in entrapment neuropathy,” Pain, vol. 162, no. 4, pp. 1211–1220, Apr. 2021, doi: 10.1097/j.pain.0000000000002102.

MATESANZ, Luis, Andrea C. HAUSHEER, Georgios BASKOZOS, David L. H. BENNETT und Annina B. SCHMID, 2021. Somatosensory and psychological phenotypes associated with neuropathic pain in entrapment neuropathy. Pain. April 2021. Bd. 162, Nr. 4, S. 1211–1220. DOI 10.1097/j.pain.0000000000002102

Matesanz, Luis, Andrea C. Hausheer, Georgios Baskozos, David L. H. Bennett, and Annina B. Schmid. 2021. “Somatosensory and Psychological Phenotypes Associated with Neuropathic Pain in Entrapment Neuropathy.” Pain 162 (4): 1211–20. https://doi.org/10.1097/j.pain.0000000000002102.

Matesanz, Luis, et al. “Somatosensory and Psychological Phenotypes Associated with Neuropathic Pain in Entrapment Neuropathy.” Pain, vol. 162, no. 4, Apr. 2021, pp. 1211–20, https://doi.org/10.1097/j.pain.0000000000002102.