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  4. Publikationen Life Sciences und Facility Management
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dc.contributor.authorTrifan, Adriana-
dc.contributor.authorZengin, Gokhan-
dc.contributor.authorSinan, Kouadio Ibrahime-
dc.contributor.authorWolfram, Evelyn-
dc.contributor.authorSkalicka-Woźniak, Krystyna-
dc.contributor.authorLuca, Simon Vlad-
dc.date.accessioned2023-08-04T08:23:10Z-
dc.date.available2023-08-04T08:23:10Z-
dc.date.issued2021-09-10-
dc.identifier.issn07317085de_CH
dc.identifier.issn1873-264Xde_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/28374-
dc.description.abstractThis study was aimed at providing a comprehensive phytochemical characterization and multi-biological assessment of Symphytum officinale L., a medicinal plant with a noteworthy traditional use, and Anchusa ochroleuca M. Bieb., a Boraginaceae species from the Romanian flora. The dichloromethane, methanol and 65 % ethanol extracts obtained from the roots and aerial parts of both plants revealed the presence of numerous phenolic acids, oxygenated fatty acids, pyrrolizidine alkaloids (PAs) and flavonoids, as assessed by LC-HRMS/MS analysis. Consistent with their higher total phenolic content, the polar aerial part extracts of S. officinale and root extracts of A. ochroleuca showed the most significant antioxidant activities, as evaluated by DPPH (173.22-216.98 mg TE/g) and ABTS (219.41-311.97 mg TE/g) radical scavenging, CUPRAC (387.18-626.40 mg TE/g), FRAP (199.36-299.86 mg TE/g) and total antioxidant capacity (2.28-2.68 mmol TE/g). Furthermore, both plants exhibited good tyrosinase (19.11-43.89 mg KAE/g) and α-glucosidase (2.45-12.54 mmol ACAE/g) inhibitory effects. The orthogonal projections to latent structures discriminant analysis (OPLS-DA) allowed the objective differentiation between the roots and aerial parts of the two investigated species based on their phytochemical and biological profiles. The partial least square (PLS) analysis showed that several individual phenolic acids, such as danshensu, rabdosiin and rosmarinic acid, significantly contributed to the antioxidant potential of both Boraginaceae species, whilst the relative levels of sucrose were positively correlated with the anti-enzymatic properties. Overall, S. officinale and A. ochroleuca could be regarded as rich sources of bioactive phytochemicals that could further lead to developing novel phyto-pharmaceutical commodities.de_CH
dc.language.isoende_CH
dc.publisherElsevierde_CH
dc.relation.ispartofJournal of Pharmaceutical and Biomedical Analysisde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectComfreyde_CH
dc.subjectEnzyme inhibitorde_CH
dc.subjectLC-HRMS/MSde_CH
dc.subjectSymphytum officinalede_CH
dc.subjectAntioxidantde_CH
dc.subjectAnchusa ochroleucade_CH
dc.subject.ddc572: Biochemiede_CH
dc.titleLC-HRMS/MS phytochemical profiling of Symphytum officinale L. and Anchusa ochroleuca M. Bieb. (Boraginaceae) : unveiling their multi-biological potential via an integrated approachde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
dc.identifier.doi10.1016/j.jpba.2021.114283de_CH
dc.identifier.pmid34329923de_CH
zhaw.funding.euNode_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.start114283de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume204de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
Appears in collections:Publikationen Life Sciences und Facility Management

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Trifan, A., Zengin, G., Sinan, K. I., Wolfram, E., Skalicka-Woźniak, K., & Luca, S. V. (2021). LC-HRMS/MS phytochemical profiling of Symphytum officinale L. and Anchusa ochroleuca M. Bieb. (Boraginaceae) : unveiling their multi-biological potential via an integrated approach. Journal of Pharmaceutical and Biomedical Analysis, 204, 114283. https://doi.org/10.1016/j.jpba.2021.114283
Trifan, A. et al. (2021) ‘LC-HRMS/MS phytochemical profiling of Symphytum officinale L. and Anchusa ochroleuca M. Bieb. (Boraginaceae) : unveiling their multi-biological potential via an integrated approach’, Journal of Pharmaceutical and Biomedical Analysis, 204, p. 114283. Available at: https://doi.org/10.1016/j.jpba.2021.114283.
A. Trifan, G. Zengin, K. I. Sinan, E. Wolfram, K. Skalicka-Woźniak, and S. V. Luca, “LC-HRMS/MS phytochemical profiling of Symphytum officinale L. and Anchusa ochroleuca M. Bieb. (Boraginaceae) : unveiling their multi-biological potential via an integrated approach,” Journal of Pharmaceutical and Biomedical Analysis, vol. 204, p. 114283, Sep. 2021, doi: 10.1016/j.jpba.2021.114283.
TRIFAN, Adriana, Gokhan ZENGIN, Kouadio Ibrahime SINAN, Evelyn WOLFRAM, Krystyna SKALICKA-WOŹNIAK und Simon Vlad LUCA, 2021. LC-HRMS/MS phytochemical profiling of Symphytum officinale L. and Anchusa ochroleuca M. Bieb. (Boraginaceae) : unveiling their multi-biological potential via an integrated approach. Journal of Pharmaceutical and Biomedical Analysis. 10 September 2021. Bd. 204, S. 114283. DOI 10.1016/j.jpba.2021.114283
Trifan, Adriana, Gokhan Zengin, Kouadio Ibrahime Sinan, Evelyn Wolfram, Krystyna Skalicka-Woźniak, and Simon Vlad Luca. 2021. “LC-HRMS/MS Phytochemical Profiling of Symphytum Officinale L. And Anchusa Ochroleuca M. Bieb. (Boraginaceae) : Unveiling Their Multi-Biological Potential via an Integrated Approach.” Journal of Pharmaceutical and Biomedical Analysis 204 (September): 114283. https://doi.org/10.1016/j.jpba.2021.114283.
Trifan, Adriana, et al. “LC-HRMS/MS Phytochemical Profiling of Symphytum Officinale L. And Anchusa Ochroleuca M. Bieb. (Boraginaceae) : Unveiling Their Multi-Biological Potential via an Integrated Approach.” Journal of Pharmaceutical and Biomedical Analysis, vol. 204, Sept. 2021, p. 114283, https://doi.org/10.1016/j.jpba.2021.114283.


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