| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | LC-HRMS/MS phytochemical profiling of Symphytum officinale L. and Anchusa ochroleuca M. Bieb. (Boraginaceae) : unveiling their multi-biological potential via an integrated approach |
| Autor/-in: | Trifan, Adriana Zengin, Gokhan Sinan, Kouadio Ibrahime Wolfram, Evelyn Skalicka-Woźniak, Krystyna Luca, Simon Vlad |
| et. al: | No |
| DOI: | 10.1016/j.jpba.2021.114283 |
| Erschienen in: | Journal of Pharmaceutical and Biomedical Analysis |
| Band(Heft): | 204 |
| Seite(n): | 114283 |
| Erscheinungsdatum: | 10-Sep-2021 |
| Verlag / Hrsg. Institution: | Elsevier |
| ISSN: | 07317085 1873-264X |
| Sprache: | Englisch |
| Schlagwörter: | Comfrey; Enzyme inhibitor; LC-HRMS/MS; Symphytum officinale; Antioxidant; Anchusa ochroleuca |
| Fachgebiet (DDC): | 572: Biochemie |
| Zusammenfassung: | This study was aimed at providing a comprehensive phytochemical characterization and multi-biological assessment of Symphytum officinale L., a medicinal plant with a noteworthy traditional use, and Anchusa ochroleuca M. Bieb., a Boraginaceae species from the Romanian flora. The dichloromethane, methanol and 65 % ethanol extracts obtained from the roots and aerial parts of both plants revealed the presence of numerous phenolic acids, oxygenated fatty acids, pyrrolizidine alkaloids (PAs) and flavonoids, as assessed by LC-HRMS/MS analysis. Consistent with their higher total phenolic content, the polar aerial part extracts of S. officinale and root extracts of A. ochroleuca showed the most significant antioxidant activities, as evaluated by DPPH (173.22-216.98 mg TE/g) and ABTS (219.41-311.97 mg TE/g) radical scavenging, CUPRAC (387.18-626.40 mg TE/g), FRAP (199.36-299.86 mg TE/g) and total antioxidant capacity (2.28-2.68 mmol TE/g). Furthermore, both plants exhibited good tyrosinase (19.11-43.89 mg KAE/g) and α-glucosidase (2.45-12.54 mmol ACAE/g) inhibitory effects. The orthogonal projections to latent structures discriminant analysis (OPLS-DA) allowed the objective differentiation between the roots and aerial parts of the two investigated species based on their phytochemical and biological profiles. The partial least square (PLS) analysis showed that several individual phenolic acids, such as danshensu, rabdosiin and rosmarinic acid, significantly contributed to the antioxidant potential of both Boraginaceae species, whilst the relative levels of sucrose were positively correlated with the anti-enzymatic properties. Overall, S. officinale and A. ochroleuca could be regarded as rich sources of bioactive phytochemicals that could further lead to developing novel phyto-pharmaceutical commodities. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/28374 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | Lizenz gemäss Verlagsvertrag |
| Departement: | Life Sciences und Facility Management |
| Organisationseinheit: | Institut für Chemie und Biotechnologie (ICBT) |
| Enthalten in den Sammlungen: | Publikationen Life Sciences und Facility Management |
Dateien zu dieser Ressource:
Es gibt keine Dateien zu dieser Ressource.
Zur Langanzeige
Trifan, A., Zengin, G., Sinan, K. I., Wolfram, E., Skalicka-Woźniak, K., & Luca, S. V. (2021). LC-HRMS/MS phytochemical profiling of Symphytum officinale L. and Anchusa ochroleuca M. Bieb. (Boraginaceae) : unveiling their multi-biological potential via an integrated approach. Journal of Pharmaceutical and Biomedical Analysis, 204, 114283. https://doi.org/10.1016/j.jpba.2021.114283
Trifan, A. et al. (2021) ‘LC-HRMS/MS phytochemical profiling of Symphytum officinale L. and Anchusa ochroleuca M. Bieb. (Boraginaceae) : unveiling their multi-biological potential via an integrated approach’, Journal of Pharmaceutical and Biomedical Analysis, 204, p. 114283. Available at: https://doi.org/10.1016/j.jpba.2021.114283.
A. Trifan, G. Zengin, K. I. Sinan, E. Wolfram, K. Skalicka-Woźniak, and S. V. Luca, “LC-HRMS/MS phytochemical profiling of Symphytum officinale L. and Anchusa ochroleuca M. Bieb. (Boraginaceae) : unveiling their multi-biological potential via an integrated approach,” Journal of Pharmaceutical and Biomedical Analysis, vol. 204, p. 114283, Sep. 2021, doi: 10.1016/j.jpba.2021.114283.
TRIFAN, Adriana, Gokhan ZENGIN, Kouadio Ibrahime SINAN, Evelyn WOLFRAM, Krystyna SKALICKA-WOŹNIAK und Simon Vlad LUCA, 2021. LC-HRMS/MS phytochemical profiling of Symphytum officinale L. and Anchusa ochroleuca M. Bieb. (Boraginaceae) : unveiling their multi-biological potential via an integrated approach. Journal of Pharmaceutical and Biomedical Analysis. 10 September 2021. Bd. 204, S. 114283. DOI 10.1016/j.jpba.2021.114283
Trifan, Adriana, Gokhan Zengin, Kouadio Ibrahime Sinan, Evelyn Wolfram, Krystyna Skalicka-Woźniak, and Simon Vlad Luca. 2021. “LC-HRMS/MS Phytochemical Profiling of Symphytum Officinale L. And Anchusa Ochroleuca M. Bieb. (Boraginaceae) : Unveiling Their Multi-Biological Potential via an Integrated Approach.” Journal of Pharmaceutical and Biomedical Analysis 204 (September): 114283. https://doi.org/10.1016/j.jpba.2021.114283.
Trifan, Adriana, et al. “LC-HRMS/MS Phytochemical Profiling of Symphytum Officinale L. And Anchusa Ochroleuca M. Bieb. (Boraginaceae) : Unveiling Their Multi-Biological Potential via an Integrated Approach.” Journal of Pharmaceutical and Biomedical Analysis, vol. 204, Sept. 2021, p. 114283, https://doi.org/10.1016/j.jpba.2021.114283.
Alle Ressourcen in diesem Repository sind urheberrechtlich geschützt, soweit nicht anderweitig angezeigt.