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Publication type: Article in scientific journal
Type of review: Peer review (publication)
Title: Mechanical catalysis on the centimetre scale
Authors: Miyashita, Shuhei
Audretsch, Christof
Nagy, Zoltán
Füchslin, Rudolf Marcel
Pfeifer, Rolf
DOI: 10.21256/zhaw-1651
Published in: Journal of the Royal Society Interface
Volume(Issue): 12
Issue: 104
Issue Date: 2015
Publisher / Ed. Institution: The Royal Society
ISSN: 1742-5689
Language: English
Subjects: Magnetic catalysis; Enzyme; Inhibitor; Conformation change; Autocatalysis; Reaction phase
Subject (DDC): 540: Chemistry
572: Biochemistry
Abstract: Enzymes play important roles in catalysing biochemical transaction paths, acting as logical machines through the morphology of the processes. A key challenge in elucidating the nature of these systems, and for engineering manufacturing methods inspired by biochemical reactions, is to attain a comprehensive understanding of the stereochemical ground rules of enzymatic reactions. Here, we present a model of catalysis that can be performed magnetically by centimetre-sized passive floating units. The designed system, which is equipped with permanent magnets only, passively obeys the local causalities imposed by magnetic interactions, albeit it shows a spatial behaviour and an energy profile analogous to those of biochemical enzymes. In this process, the enzyme units trigger physical conformation changes of the target by levelling out the magnetic potential barrier (activation potential) to a funnel type and, thus, induce cascading conformation changes of the targeted substrate units reacting in parallel. The inhibitor units, conversely, suppress such changes by increasing the potential. Because the model is purely mechanical and established on a physics basis in the absence of turbulence, each performance can be explained by the morphology of the unit, extending the definition of catalysis to systems of alternative scales.
Fulltext version: Published version
License (according to publishing contract): CC BY-NC 4.0: Attribution - Non commercial 4.0 International
Departement: School of Engineering
Appears in Collections:Publikationen School of Engineering

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