Biomaterial-mediated factor delivery for spinal cord injury treatment

Pinelli, Filippo; Pizzetti, Fabio; Veneruso, Valeria; Petillo, Emilia; Raghunath, Michael; Perale, Giuseppe; Veglianese, Pietro; Rossi, Filippo

doi:10.3390/biomedicines10071673

Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-26838

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Biomaterial-mediated factor delivery for spinal cord injury treatment
Authors:	Pinelli, Filippo Pizzetti, Fabio Veneruso, Valeria Petillo, Emilia Raghunath, Michael Perale, Giuseppe Veglianese, Pietro Rossi, Filippo
et. al:	No
DOI:	10.3390/biomedicines10071673 10.21256/zhaw-26838
Published in:	Biomedicines
Volume(Issue):	10
Issue:	7
Page(s):	1673
Issue Date:	2022
Publisher / Ed. Institution:	MDPI
ISSN:	2227-9059
Language:	English
Subjects:	Hydrogel; Inflammation; Nanoparticle; Regeneration; Spinal cord
Subject (DDC):	610.28: Biomedicine, biomedical engineering
Abstract:	Spinal cord injury (SCI) is an injurious process that begins with immediate physical damage to the spinal cord and associated tissues during an acute traumatic event. However, the tissue damage expands in both intensity and volume in the subsequent subacute phase. At this stage, numerous events exacerbate the pathological condition, and therein lies the main cause of post-traumatic neural degeneration, which then ends with the chronic phase. In recent years, therapeutic interventions addressing different neurodegenerative mechanisms have been proposed, but have met with limited success when translated into clinical settings. The underlying reasons for this are that the pathogenesis of SCI is a continued multifactorial disease, and the treatment of only one factor is not sufficient to curb neural degeneration and resulting paralysis. Recent advances have led to the development of biomaterials aiming to promote in situ combinatorial strategies using drugs/biomolecules to achieve a maximized multitarget approach. This review provides an overview of single and combinatorial regenerative-factor-based treatments as well as potential delivery options to treat SCIs.
URI:	https://digitalcollection.zhaw.ch/handle/11475/26838
Fulltext version:	Published version
License (according to publishing contract):	CC BY 4.0: Attribution 4.0 International
Departement:	Life Sciences and Facility Management
Organisational Unit:	Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:	Publikationen Life Sciences und Facility Management

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Pinelli, F., Pizzetti, F., Veneruso, V., Petillo, E., Raghunath, M., Perale, G., Veglianese, P., & Rossi, F. (2022). Biomaterial-mediated factor delivery for spinal cord injury treatment. Biomedicines, 10(7), 1673. https://doi.org/10.3390/biomedicines10071673

Pinelli, F. et al. (2022) ‘Biomaterial-mediated factor delivery for spinal cord injury treatment’, Biomedicines, 10(7), p. 1673. Available at: https://doi.org/10.3390/biomedicines10071673.

F. Pinelli et al., “Biomaterial-mediated factor delivery for spinal cord injury treatment,” Biomedicines, vol. 10, no. 7, p. 1673, 2022, doi: 10.3390/biomedicines10071673.

PINELLI, Filippo, Fabio PIZZETTI, Valeria VENERUSO, Emilia PETILLO, Michael RAGHUNATH, Giuseppe PERALE, Pietro VEGLIANESE und Filippo ROSSI, 2022. Biomaterial-mediated factor delivery for spinal cord injury treatment. Biomedicines. 2022. Bd. 10, Nr. 7, S. 1673. DOI 10.3390/biomedicines10071673

Pinelli, Filippo, Fabio Pizzetti, Valeria Veneruso, Emilia Petillo, Michael Raghunath, Giuseppe Perale, Pietro Veglianese, and Filippo Rossi. 2022. “Biomaterial-Mediated Factor Delivery for Spinal Cord Injury Treatment.” Biomedicines 10 (7): 1673. https://doi.org/10.3390/biomedicines10071673.

Pinelli, Filippo, et al. “Biomaterial-Mediated Factor Delivery for Spinal Cord Injury Treatment.” Biomedicines, vol. 10, no. 7, 2022, p. 1673, https://doi.org/10.3390/biomedicines10071673.