Efficacy and safety of P11-4 for the treatment of periodontal defects in dogs

Bommer, Claudine; Waller, Tobias; Hilbe, Monika; Wiedemeier, Daniel; Meyer, Nina; Mathes, Stephanie; Jung, Ronald

doi:10.1007/s00784-021-04297-6

Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-26763

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Efficacy and safety of P11-4 for the treatment of periodontal defects in dogs
Authors:	Bommer, Claudine Waller, Tobias Hilbe, Monika Wiedemeier, Daniel Meyer, Nina Mathes, Stephanie Jung, Ronald
et. al:	No
DOI:	10.1007/s00784-021-04297-6 10.21256/zhaw-26763
Published in:	Clinical Oral Investigations
Volume(Issue):	26
Issue:	3
Page(s):	3151
Pages to:	3166
Issue Date:	2022
Publisher / Ed. Institution:	Springer
ISSN:	1432-6981 1436-3771
Language:	English
Subjects:	Dehiscence defect; Dog; Periodontal disease; Regenerative scaffold; Self-assembling peptide P11-4; Alveolar bone loss; Animal; Bone regeneration; Dental cementum; Mandible; Tooth root; X-ray microtomography; Guided tissue regeneration, periodontal; Oligopeptide; Periodontal ligament
Subject (DDC):	617: Surgery
Abstract:	Objectives: This study’s aim was to investigate the safety and performance of a self-assembling peptide matrix (SAPM) P11-4 for the treatment of periodontal disease in a controlled pre-clinical study. Materials and methods: Acute buccal bony dehiscence defects (LxW: 5 × 3 mm) were surgically created on the distal root of four teeth on one mandible side of 7 beagle dogs followed by another identical surgery 8 weeks later on the contralateral side. SAPM P11-4 (with and without root conditioning with 24% EDTA (T1, T2)), Emdogain® (C) and a sham intervention (S) were randomly applied on the four defects at each time point. Four weeks after the second surgery and treatment, the animals were sacrificed, the mandibles measured by micro-computed tomography (µ-CT) and sections of the tissue were stained and evaluated histologically. Results: Clinically and histologically, no safety concerns or pathological issues due to the treatments were observed in any of the study groups at any time point. All groups showed overall similar results after 4 and 12 weeks of healing regarding new cementum, functionality of newly formed periodontal ligament and recovery of height and volume of the new alveolar bone and mineral density. Conclusion: A controlled clinical study in humans should be performed in a next step as no adverse effects or safety issues, which might affect clinical usage of the product, were observed. Clinical relevance: The synthetic SAPM P11-4 may offer an alternative to the animal-derived product Emdogain® in the future.
Further description:	Erworben im Rahmen der Schweizer Nationallizenzen (http://www.nationallizenzen.ch)
URI:	https://digitalcollection.zhaw.ch/handle/11475/26763
Fulltext version:	Published version
License (according to publishing contract):	CC BY 4.0: Attribution 4.0 International
Departement:	Life Sciences and Facility Management
Organisational Unit:	Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:	Publikationen Life Sciences und Facility Management

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Bommer, C., Waller, T., Hilbe, M., Wiedemeier, D., Meyer, N., Mathes, S., & Jung, R. (2022). Efficacy and safety of P11-4 for the treatment of periodontal defects in dogs. Clinical Oral Investigations, 26(3), 3151–3166. https://doi.org/10.1007/s00784-021-04297-6

Bommer, C. et al. (2022) ‘Efficacy and safety of P11-4 for the treatment of periodontal defects in dogs’, Clinical Oral Investigations, 26(3), pp. 3151–3166. Available at: https://doi.org/10.1007/s00784-021-04297-6.

C. Bommer et al., “Efficacy and safety of P11-4 for the treatment of periodontal defects in dogs,” Clinical Oral Investigations, vol. 26, no. 3, pp. 3151–3166, 2022, doi: 10.1007/s00784-021-04297-6.

BOMMER, Claudine, Tobias WALLER, Monika HILBE, Daniel WIEDEMEIER, Nina MEYER, Stephanie MATHES und Ronald JUNG, 2022. Efficacy and safety of P11-4 for the treatment of periodontal defects in dogs. Clinical Oral Investigations. 2022. Bd. 26, Nr. 3, S. 3151–3166. DOI 10.1007/s00784-021-04297-6

Bommer, Claudine, Tobias Waller, Monika Hilbe, Daniel Wiedemeier, Nina Meyer, Stephanie Mathes, and Ronald Jung. 2022. “Efficacy and Safety of P11-4 for the Treatment of Periodontal Defects in Dogs.” Clinical Oral Investigations 26 (3): 3151–66. https://doi.org/10.1007/s00784-021-04297-6.

Bommer, Claudine, et al. “Efficacy and Safety of P11-4 for the Treatment of Periodontal Defects in Dogs.” Clinical Oral Investigations, vol. 26, no. 3, 2022, pp. 3151–66, https://doi.org/10.1007/s00784-021-04297-6.