|Title:||Treatment of skin disorders|
|Patent submitter:||Bacoba AG|
|Abstract:||The present invention relates to a compound of formula (I), pharmaceutically acceptable salts thereof as well as pharmaceutical compositions, for use in a method of topical treatment of a skin disease or skin disorder of a mammal, wherein said method comprises topical administration of said compound to said mammal, Formula (I) wherein R1 is selected from carbocyclyl or heterocyclyl, each independently optionally substituted with C1-C4alkyl, halogen, oxo, CF3, OR4, NR5R6, C6H5, C6H5 substituted with halogen, C1-C3alkyl, OR4, NR5R6, wherein R4, R5, R6 are independently at each occurrence H, C1-C3alkyl; R2 is selected from C5-C12alkyl, C4-C10alkoxy, C1-C3 alkyl ene-cycloalkyl, C1-C3alkylene-aryl, C1-C3alkylene-heteroaryl, wherein said alkyl, cycloalkyl, aryl and heteroaryl are each independently optionally substituted with one or more, typically and preferably one or two, substituents selected from C1-C2alkyl, C1-C2haloalkyl, halogen, C1-C2alkoxy; R3 is (Ia), wherein R7, R8, R9 and R10 are independently at each occurrence H or C1-C3alkyl, preferably H or methyl, or independently at each occurrence two of said R7, R8, R9 and R10 together with the carbon atom to which they are attached form a carbocyclic or heterocyclic ring, preferably a carbocyclic ring, and wherein R11 and R12 are independently of each other H or C1-C4alkyl optionally substituted with halogen, hydroxyl or C3-C6cycloalkyl; or together with the nitrogen atom to which they are attached form independently at each occurrence a heteroaryl or a heterocyclyl, each independently optionally substituted with halogen, C1-C4alkyl, OR13, NR14R15; wherein R13, R14, R15 are independently at each occurrence H, C1-C4alkyl, and wherein the arrow indicates the attachment to the C(O)-moiety depicted in formula (I).|
|Departement:||Life Sciences and Facility Management|
|Organisational Unit:||Institute of Chemistry and Biotechnology (ICBT)|
|Appears in collections:||Patente Life Sciences und Facility Management|
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Adams, M., Kemmler, M., Riedl, R., Pliatsika, D., Imanidis, G., Herzig, S., Kaiser, M., & Mäser, P. (2022). Treatment of skin disorders (Patent No. WO2022167656A1). https://worldwide.espacenet.com/patent/search?q=pn%3DWO2022167656A1
Adams, M. et al. (2022) ‘Treatment of skin disorders’. Available at: https://worldwide.espacenet.com/patent/search?q=pn%3DWO2022167656A1.
M. Adams et al., “Treatment of skin disorders,” WO2022167656A1, Aug. 11, 2022 [Online]. Available: https://worldwide.espacenet.com/patent/search?q=pn%3DWO2022167656A1
Adams, Michael, et al. Treatment of Skin Disorders. WO2022167656A1, 11 Aug. 2022, https://worldwide.espacenet.com/patent/search?q=pn%3DWO2022167656A1.
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