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dc.contributor.otherAdams, Michael-
dc.contributor.otherKemmler, Michael-
dc.contributor.otherRiedl, Rainer-
dc.contributor.otherPliatsika, Dimanthi-
dc.contributor.otherImanidis, Georgios-
dc.contributor.otherHerzig, Susanne-
dc.contributor.otherKaiser, Marcel-
dc.contributor.otherMäser, Pascal-
dc.date.accessioned2023-02-02T07:53:08Z-
dc.date.available2023-02-02T07:53:08Z-
dc.date.issued2022-08-11-
dc.date.submitted2022-02-07-
dc.identifier.urihttps://worldwide.espacenet.com/patent/search?q=pn%3DWO2022167656A1de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/26752-
dc.description.abstractThe present invention relates to a compound of formula (I), pharmaceutically acceptable salts thereof as well as pharmaceutical compositions, for use in a method of topical treatment of a skin disease or skin disorder of a mammal, wherein said method comprises topical administration of said compound to said mammal, Formula (I) wherein R1 is selected from carbocyclyl or heterocyclyl, each independently optionally substituted with C1-C4alkyl, halogen, oxo, CF3, OR4, NR5R6, C6H5, C6H5 substituted with halogen, C1-C3alkyl, OR4, NR5R6, wherein R4, R5, R6 are independently at each occurrence H, C1-C3alkyl; R2 is selected from C5-C12alkyl, C4-C10alkoxy, C1-C3 alkyl ene-cycloalkyl, C1-C3alkylene-aryl, C1-C3alkylene-heteroaryl, wherein said alkyl, cycloalkyl, aryl and heteroaryl are each independently optionally substituted with one or more, typically and preferably one or two, substituents selected from C1-C2alkyl, C1-C2haloalkyl, halogen, C1-C2alkoxy; R3 is (Ia), wherein R7, R8, R9 and R10 are independently at each occurrence H or C1-C3alkyl, preferably H or methyl, or independently at each occurrence two of said R7, R8, R9 and R10 together with the carbon atom to which they are attached form a carbocyclic or heterocyclic ring, preferably a carbocyclic ring, and wherein R11 and R12 are independently of each other H or C1-C4alkyl optionally substituted with halogen, hydroxyl or C3-C6cycloalkyl; or together with the nitrogen atom to which they are attached form independently at each occurrence a heteroaryl or a heterocyclyl, each independently optionally substituted with halogen, C1-C4alkyl, OR13, NR14R15; wherein R13, R14, R15 are independently at each occurrence H, C1-C4alkyl, and wherein the arrow indicates the attachment to the C(O)-moiety depicted in formula (I).de_CH
dc.description.sponsorshipBacoba AGde_CH
dc.language.isoende_CH
dc.titleTreatment of skin disordersde_CH
dc.title.alternativeTraitement de troubles cutanésde_CH
dc.typePatentde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
zhaw.funding.euNode_CH
zhaw.originated.zhawYesde_CH
zhaw.webfeedOrganische Chemiede_CH
zhaw.webfeedCC Drug Discoveryde_CH
zhaw.id.patentWO2022167656de_CH
zhaw.publication.codeA1de_CH
zhaw.display.portraitYesde_CH
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Adams, M., Kemmler, M., Riedl, R., Pliatsika, D., Imanidis, G., Herzig, S., Kaiser, M., & Mäser, P. (2022). Treatment of skin disorders (Patent No. WO2022167656A1). https://worldwide.espacenet.com/patent/search?q=pn%3DWO2022167656A1
Adams, M. et al. (2022) ‘Treatment of skin disorders’. Available at: https://worldwide.espacenet.com/patent/search?q=pn%3DWO2022167656A1.
M. Adams et al., “Treatment of skin disorders,” WO2022167656A1, Aug. 11, 2022 [Online]. Available: https://worldwide.espacenet.com/patent/search?q=pn%3DWO2022167656A1
ADAMS, Michael, Michael KEMMLER, Rainer RIEDL, Dimanthi PLIATSIKA, Georgios IMANIDIS, Susanne HERZIG, Marcel KAISER und Pascal MÄSER, 2022. Treatment of skin disorders [online]. WO2022167656A1. 11 August 2022. Verfügbar unter: https://worldwide.espacenet.com/patent/search?q=pn%3DWO2022167656A1
Adams, Michael, Michael Kemmler, Rainer Riedl, Dimanthi Pliatsika, Georgios Imanidis, Susanne Herzig, Marcel Kaiser, and Pascal Mäser. 2022. Treatment of skin disorders. WO2022167656A1, filed February 7, 2022, and issued August 11, 2022. https://worldwide.espacenet.com/patent/search?q=pn%3DWO2022167656A1.
Adams, Michael, et al. Treatment of Skin Disorders. WO2022167656A1, 11 Aug. 2022, https://worldwide.espacenet.com/patent/search?q=pn%3DWO2022167656A1.


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