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  2. School of Engineering
  3. Publikationen
  4. Publikationen School of Engineering
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dc.contributor.authorMeier, Valeria S.-
dc.contributor.authorBeatrice, Laura-
dc.contributor.authorTurek, Michelle-
dc.contributor.authorPoirier, Valerie J.-
dc.contributor.authorCancedda, Simona-
dc.contributor.authorStiborova, Katerina-
dc.contributor.authorKörner, Maximilian-
dc.contributor.authorMarconato, Laura-
dc.contributor.authorWeyland, Mathias S.-
dc.contributor.authorRohrer Bley, Carla-
dc.date.accessioned2022-11-17T11:15:45Z-
dc.date.available2022-11-17T11:15:45Z-
dc.date.issued2019-12-
dc.identifier.issn1476-5810de_CH
dc.identifier.issn1476-5829de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/26088-
dc.description.abstractFailure rate and site are not well defined in localized sinonasal lymphoma in cats treated with radiotherapy. In this study, we describe (a) failure pattern, (b) outcome, (c) influence of previously reported prognostic variables on the outcome in cats with suspected localized sinonasal lymphoma. In this multi-institutional retrospective study, we included 51 cats treated with single-modality radiotherapy. Cats were irradiated using 10x4.2Gy (n = 32), 12x3Gy (n = 11) or 5x6Gy (n = 8). Regional lymph nodes were prophylactically irradiated in 24/51 cats (47.1%). Twenty-five cats (49.0%) developed progressive disease: progression was local (nasal) in five (9.8%), locoregional (nodal) in two (3.9%), local and locoregional in three (5.9%), systemic in nine (17.6%) and both local and systemic in six cats (11.8%). No cat receiving prophylactic nodal irradiation had progression in the locoregional lymph nodes. The median time to progression was 974 days (95%CI: 283;1666), with 58% and 53% of cats free of progression at 1 and 2 years, respectively. Median overall survival was 922 days (95%CI: 66;1779) with 61% and 49% alive at 1 and 2 years, respectively. Half of the cats that died of relapse/progression (13/26) died within 6 months of treatment, suggesting possible shortcomings of staging, rapid dissemination of disease or sequential lymphomagenesis. None of the prognostic factors evaluated were predictive of outcome (prednisolone use, anaemia, nasopharyngeal involvement, modified canine Adams tumour stage, protocol, total dose). Radiotherapy is an effective treatment for localized sinonasal lymphoma with a long time to progression. However, in one-third of the cats, systemic disease progression occurs soon after radiotherapy.de_CH
dc.language.isoende_CH
dc.publisherWileyde_CH
dc.relation.ispartofVeterinary and Comparative Oncologyde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectIMRTde_CH
dc.subjectCancerde_CH
dc.subjectFelinede_CH
dc.subjectLymphoproliferativede_CH
dc.subjectNasalde_CH
dc.subjectAnimalde_CH
dc.subjectCat diseasede_CH
dc.subjectCatde_CH
dc.subjectDisease-free survivalde_CH
dc.subjectFemalede_CH
dc.subjectLymphomade_CH
dc.subjectMalede_CH
dc.subjectNeoplasm recurrence, localde_CH
dc.subjectNose neoplasmde_CH
dc.subjectRetrospective studyde_CH
dc.subjectTreatment outcomede_CH
dc.subject.ddc616: Innere Medizin und Krankheitende_CH
dc.subject.ddc630: Landwirtschaftde_CH
dc.titleOutcome and failure patterns of localized sinonasal lymphoma in cats treated with first-line single-modality radiation therapy : a retrospective studyde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementSchool of Engineeringde_CH
zhaw.organisationalunitInstitut für Angewandte Mathematik und Physik (IAMP)de_CH
dc.identifier.doi10.1111/vco.12517de_CH
dc.identifier.pmid31254440de_CH
zhaw.funding.euNode_CH
zhaw.issue4de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end536de_CH
zhaw.pages.start528de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume17de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
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Meier, V. S., Beatrice, L., Turek, M., Poirier, V. J., Cancedda, S., Stiborova, K., Körner, M., Marconato, L., Weyland, M. S., & Rohrer Bley, C. (2019). Outcome and failure patterns of localized sinonasal lymphoma in cats treated with first-line single-modality radiation therapy : a retrospective study. Veterinary and Comparative Oncology, 17(4), 528–536. https://doi.org/10.1111/vco.12517
Meier, V.S. et al. (2019) ‘Outcome and failure patterns of localized sinonasal lymphoma in cats treated with first-line single-modality radiation therapy : a retrospective study’, Veterinary and Comparative Oncology, 17(4), pp. 528–536. Available at: https://doi.org/10.1111/vco.12517.
V. S. Meier et al., “Outcome and failure patterns of localized sinonasal lymphoma in cats treated with first-line single-modality radiation therapy : a retrospective study,” Veterinary and Comparative Oncology, vol. 17, no. 4, pp. 528–536, Dec. 2019, doi: 10.1111/vco.12517.
MEIER, Valeria S., Laura BEATRICE, Michelle TUREK, Valerie J. POIRIER, Simona CANCEDDA, Katerina STIBOROVA, Maximilian KÖRNER, Laura MARCONATO, Mathias S. WEYLAND und Carla ROHRER BLEY, 2019. Outcome and failure patterns of localized sinonasal lymphoma in cats treated with first-line single-modality radiation therapy : a retrospective study. Veterinary and Comparative Oncology. Dezember 2019. Bd. 17, Nr. 4, S. 528–536. DOI 10.1111/vco.12517
Meier, Valeria S., Laura Beatrice, Michelle Turek, Valerie J. Poirier, Simona Cancedda, Katerina Stiborova, Maximilian Körner, Laura Marconato, Mathias S. Weyland, and Carla Rohrer Bley. 2019. “Outcome and Failure Patterns of Localized Sinonasal Lymphoma in Cats Treated with First-Line Single-Modality Radiation Therapy : A Retrospective Study.” Veterinary and Comparative Oncology 17 (4): 528–36. https://doi.org/10.1111/vco.12517.
Meier, Valeria S., et al. “Outcome and Failure Patterns of Localized Sinonasal Lymphoma in Cats Treated with First-Line Single-Modality Radiation Therapy : A Retrospective Study.” Veterinary and Comparative Oncology, vol. 17, no. 4, Dec. 2019, pp. 528–36, https://doi.org/10.1111/vco.12517.


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