| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | Outcome and failure patterns of localized sinonasal lymphoma in cats treated with first-line single-modality radiation therapy : a retrospective study |
| Autor/-in: | Meier, Valeria S. Beatrice, Laura Turek, Michelle Poirier, Valerie J. Cancedda, Simona Stiborova, Katerina Körner, Maximilian Marconato, Laura Weyland, Mathias S. Rohrer Bley, Carla |
| et. al: | No |
| DOI: | 10.1111/vco.12517 |
| Erschienen in: | Veterinary and Comparative Oncology |
| Band(Heft): | 17 |
| Heft: | 4 |
| Seite(n): | 528 |
| Seiten bis: | 536 |
| Erscheinungsdatum: | Dez-2019 |
| Verlag / Hrsg. Institution: | Wiley |
| ISSN: | 1476-5810 1476-5829 |
| Sprache: | Englisch |
| Schlagwörter: | IMRT; Cancer; Feline; Lymphoproliferative; Nasal; Animal; Cat disease; Cat; Disease-free survival; Female; Lymphoma; Male; Neoplasm recurrence, local; Nose neoplasm; Retrospective study; Treatment outcome |
| Fachgebiet (DDC): | 616: Innere Medizin und Krankheiten 630: Landwirtschaft |
| Zusammenfassung: | Failure rate and site are not well defined in localized sinonasal lymphoma in cats treated with radiotherapy. In this study, we describe (a) failure pattern, (b) outcome, (c) influence of previously reported prognostic variables on the outcome in cats with suspected localized sinonasal lymphoma. In this multi-institutional retrospective study, we included 51 cats treated with single-modality radiotherapy. Cats were irradiated using 10x4.2Gy (n = 32), 12x3Gy (n = 11) or 5x6Gy (n = 8). Regional lymph nodes were prophylactically irradiated in 24/51 cats (47.1%). Twenty-five cats (49.0%) developed progressive disease: progression was local (nasal) in five (9.8%), locoregional (nodal) in two (3.9%), local and locoregional in three (5.9%), systemic in nine (17.6%) and both local and systemic in six cats (11.8%). No cat receiving prophylactic nodal irradiation had progression in the locoregional lymph nodes. The median time to progression was 974 days (95%CI: 283;1666), with 58% and 53% of cats free of progression at 1 and 2 years, respectively. Median overall survival was 922 days (95%CI: 66;1779) with 61% and 49% alive at 1 and 2 years, respectively. Half of the cats that died of relapse/progression (13/26) died within 6 months of treatment, suggesting possible shortcomings of staging, rapid dissemination of disease or sequential lymphomagenesis. None of the prognostic factors evaluated were predictive of outcome (prednisolone use, anaemia, nasopharyngeal involvement, modified canine Adams tumour stage, protocol, total dose). Radiotherapy is an effective treatment for localized sinonasal lymphoma with a long time to progression. However, in one-third of the cats, systemic disease progression occurs soon after radiotherapy. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/26088 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | Lizenz gemäss Verlagsvertrag |
| Departement: | School of Engineering |
| Organisationseinheit: | Institut für Angewandte Mathematik und Physik (IAMP) |
| Enthalten in den Sammlungen: | Publikationen School of Engineering |
Dateien zu dieser Ressource:
Es gibt keine Dateien zu dieser Ressource.
Zur Langanzeige
Meier, V. S., Beatrice, L., Turek, M., Poirier, V. J., Cancedda, S., Stiborova, K., Körner, M., Marconato, L., Weyland, M. S., & Rohrer Bley, C. (2019). Outcome and failure patterns of localized sinonasal lymphoma in cats treated with first-line single-modality radiation therapy : a retrospective study. Veterinary and Comparative Oncology, 17(4), 528–536. https://doi.org/10.1111/vco.12517
Meier, V.S. et al. (2019) ‘Outcome and failure patterns of localized sinonasal lymphoma in cats treated with first-line single-modality radiation therapy : a retrospective study’, Veterinary and Comparative Oncology, 17(4), pp. 528–536. Available at: https://doi.org/10.1111/vco.12517.
V. S. Meier et al., “Outcome and failure patterns of localized sinonasal lymphoma in cats treated with first-line single-modality radiation therapy : a retrospective study,” Veterinary and Comparative Oncology, vol. 17, no. 4, pp. 528–536, Dec. 2019, doi: 10.1111/vco.12517.
MEIER, Valeria S., Laura BEATRICE, Michelle TUREK, Valerie J. POIRIER, Simona CANCEDDA, Katerina STIBOROVA, Maximilian KÖRNER, Laura MARCONATO, Mathias S. WEYLAND und Carla ROHRER BLEY, 2019. Outcome and failure patterns of localized sinonasal lymphoma in cats treated with first-line single-modality radiation therapy : a retrospective study. Veterinary and Comparative Oncology. Dezember 2019. Bd. 17, Nr. 4, S. 528–536. DOI 10.1111/vco.12517
Meier, Valeria S., Laura Beatrice, Michelle Turek, Valerie J. Poirier, Simona Cancedda, Katerina Stiborova, Maximilian Körner, Laura Marconato, Mathias S. Weyland, and Carla Rohrer Bley. 2019. “Outcome and Failure Patterns of Localized Sinonasal Lymphoma in Cats Treated with First-Line Single-Modality Radiation Therapy : A Retrospective Study.” Veterinary and Comparative Oncology 17 (4): 528–36. https://doi.org/10.1111/vco.12517.
Meier, Valeria S., et al. “Outcome and Failure Patterns of Localized Sinonasal Lymphoma in Cats Treated with First-Line Single-Modality Radiation Therapy : A Retrospective Study.” Veterinary and Comparative Oncology, vol. 17, no. 4, Dec. 2019, pp. 528–36, https://doi.org/10.1111/vco.12517.
Alle Ressourcen in diesem Repository sind urheberrechtlich geschützt, soweit nicht anderweitig angezeigt.