Title: A novel 99mTc labelling strategy for the development of silica based particles for medical applications
Authors : Wuillemin, Michel A.
Stuber, Wanda T.
Fox, Thomas
Reber, Michael J.
Brühwiler, Dominik
Alberto, Roger
Braband, Henrik
Published in : Dalton Transactions
Volume(Issue) : 43
Issue : 11
Pages : 4260
Pages to: 4263
Publisher / Ed. Institution : Royal Society of Chemistry
Issue Date: 2014
License (according to publishing contract) : Licence according to publishing contract
Type of review: Peer review (Publication)
Language : English
Subjects : Technetium; Mesoporous; Radioimaging; Silica
Subject (DDC) : 540: Chemistry
610: Medicine and health
Abstract: The reaction of high-valent fac-{99mTcO3}+ complexes with alkenes ((3 + 2)-cycloaddition) has been used to develop a novel labelling procedure for silica based particles. This strategy can help to gain more detailed in vivo data of mesoporous silica by non-invasive radioimaging in the future. By applying norbornene as a coupling unit the (3 + 2)-cycloaddition reaction proceeds stereoselectively and with high reaction rates.
Departement: Life Sciences und Facility Management
Organisational Unit: Institute of Chemistry and Biotechnology (ICBT)
Publication type: Article in scientific Journal
DOI : 10.1039/C3DT53019A
ISSN: 1477-9226
URI: https://digitalcollection.zhaw.ch/handle/11475/2607
Published as part of the ZHAW project : Molecular Alignment Chips (MACs)
Appears in Collections:Publikationen Life Sciences und Facility Management

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