Publication type: Article in scientific journal
Type of review: Peer review (publication)
Title: Cold pressor test in spinal cord injury – revisited
Authors: Hubli, Michèle
Bolt, Doris
Krassioukov, Andrei V
et. al: No
DOI: 10.1038/s41393-017-0037-z
Published in: Spinal Cord
Volume(Issue): 56
Issue: 6
Page(s): 528
Pages to: 537
Issue Date: 2017
Publisher / Ed. Institution: Nature Publishing Group
ISSN: 1362-4393
Language: English
Subjects: Autonomic nervous system disease; Foot; Hand; Human; Spinal cord injury; Cold temperature; Hemodynamic
Subject (DDC): 616: Internal medicine and diseases
617: Surgery
Abstract: Study design : Systematic review. Objectives : A spinal cord injury (SCI) commonly results in alterations of cardiovascular physiology. In order to investigate such alterations, the cold pressor test (CPT) has been used as an established challenge test. This review summarizes the basic physiology underlying a CPT, discusses potential mechanisms responsible for abnormal pressor responses following SCI, and highlights the utility of CPT in the SCI population. Setting : Canada and Switzerland. Methods : we have completed a comprehensive review of studies that have investigated the effect of foot or hand CPT on hemodynamic indices in individuals with SCI. Results : Depending on the level of spinal cord lesion and the location of cold application, i.e., above or below the lesion, mean arterial pressure typically increases (ranging between 4 and 23 mmHg), while heart rate responses demonstrated either a decrease or an increase (ranging between −4 and 24 bpm) during CPT. The increase in blood pressure during foot CPT in high-level lesions might not necessarily be attributed to a physiological CPT response as seen in able-bodied individuals, but rather due to a reflexic sympathetic discharge below the level of lesion, known as autonomic dysreflexia. Conclusions : Further investigations in a wider range of individuals with SCI including incomplete injuries might be helpful to examine the ability of CPT assessing the integrity of the autonomic nervous system following SCI. Furthermore, additional autonomic tests are needed to emphasize the integrity of autonomic pathways and to account for the complexity of the autonomic nervous system.
Fulltext version: Published version
License (according to publishing contract): Licence according to publishing contract
Departement: School of Health Sciences
Organisational Unit: Institute of Physiotherapy (IPT)
Appears in collections:Publikationen Gesundheit

Files in This Item:
There are no files associated with this item.
Show full item record
Hubli, M., Bolt, D., & Krassioukov, A. V. (2017). Cold pressor test in spinal cord injury – revisited. Spinal Cord, 56(6), 528–537.
Hubli, M., Bolt, D. and Krassioukov, A.V. (2017) ‘Cold pressor test in spinal cord injury – revisited’, Spinal Cord, 56(6), pp. 528–537. Available at:
M. Hubli, D. Bolt, and A. V. Krassioukov, “Cold pressor test in spinal cord injury – revisited,” Spinal Cord, vol. 56, no. 6, pp. 528–537, 2017, doi: 10.1038/s41393-017-0037-z.
HUBLI, Michèle, Doris BOLT und Andrei V KRASSIOUKOV, 2017. Cold pressor test in spinal cord injury – revisited. Spinal Cord. 2017. Bd. 56, Nr. 6, S. 528–537. DOI 10.1038/s41393-017-0037-z
Hubli, Michèle, Doris Bolt, and Andrei V Krassioukov. 2017. “Cold Pressor Test in Spinal Cord Injury – Revisited.” Spinal Cord 56 (6): 528–37.
Hubli, Michèle, et al. “Cold Pressor Test in Spinal Cord Injury – Revisited.” Spinal Cord, vol. 56, no. 6, 2017, pp. 528–37,

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.