Long-term facilitation of ventilation in humans with chronic spinal cord injury

Tester J., Nicole; Fuller, David D.; Fromm, Jason S.; Spiess, Martina R.; Behrman, Andrea L.; Mateika, Jason H.

doi:10.1164/rccm.201305-0848OC

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Long-term facilitation of ventilation in humans with chronic spinal cord injury
Authors:	Tester J., Nicole Fuller, David D. Fromm, Jason S. Spiess, Martina R. Behrman, Andrea L. Mateika, Jason H.
et. al:	No
DOI:	10.1164/rccm.201305-0848OC
Published in:	American Journal of Respiratory and Critical Care Medicine
Volume(Issue):	189
Issue:	1
Page(s):	57
Pages to:	65
Issue Date:	Jan-2014
Publisher / Ed. Institution:	American Thoracic Society
ISSN:	1073-449X 1535-4970
Language:	English
Subjects:	Adult; Aged; Female; Forced expiratory volume; Humans; Long-term care; Male; Middle aged; Respiratory mechanics; Respiratory therapy; Spinal cord Injury; Vital capacity; Hypoxia; Pulmonary ventilation; Respiration; Plasticity; Intermittent hypoxia
Subject (DDC):	615: Pharmacology and therapeutics 617: Surgery
Abstract:	Rationale: Intermittent stimulation of the respiratory system with hypoxia causes persistent increases in respiratory motor output (i.e., long-term facilitation) in animals with spinal cord injury. This paradigm, therefore, has been touted as a potential respiratory rehabilitation strategy. Objectives: To determine whether acute (daily) exposure to intermittent hypoxia can also evoke long-term facilitation of ventilation after chronic spinal cord injury in humans, and whether repeated daily exposure to intermittent hypoxia enhances the magnitude of this response. Methods: Eight individuals with incomplete spinal cord injury (.1 yr; cervical [n = 6], thoracic [n = 2]) were exposed to intermittent hypoxia (eight 2-min intervals of 8% oxygen) for 10 days. During all exposures, end-tidal carbon dioxide levels were maintained, on average, 2 mm Hg above resting values. Minute ventilation, tidal volume, and breathing frequency were measured before (baseline), during, and 30 minutes after intermittent hypoxia. Sham protocols consisted of exposure to room air and were administered to a subset of the participants (n = 4). Measurements and Main Results: Minute ventilation increased significantly for 30 minutes after acute exposure to intermittent hypoxia (P , 0.001), but not after sham exposure. However, the magnitude of ventilatory long-term facilitation was not enhanced over 10 days of intermittent hypoxia exposures. Conclusions: Ventilatory long-term facilitation can be evoked by brief periods of hypoxia in humans with chronic spinal cord injury. Thus, intermittent hypoxia may represent a strategy for inducing respiratory neuroplasticity after declines in respiratory function that are related to neurological impairment. Clinical trial registered with www.clinicaltrials.gov (NCT01272011).
URI:	https://digitalcollection.zhaw.ch/handle/11475/25562
Fulltext version:	Published version
License (according to publishing contract):	Licence according to publishing contract
Departement:	School of Health Sciences
Organisational Unit:	Institute of Occupational Therapy (IER)
Appears in collections:	Publikationen Gesundheit

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Tester J., N., Fuller, D. D., Fromm, J. S., Spiess, M. R., Behrman, A. L., & Mateika, J. H. (2014). Long-term facilitation of ventilation in humans with chronic spinal cord injury. American Journal of Respiratory and Critical Care Medicine, 189(1), 57–65. https://doi.org/10.1164/rccm.201305-0848OC

Tester J., N. et al. (2014) ‘Long-term facilitation of ventilation in humans with chronic spinal cord injury’, American Journal of Respiratory and Critical Care Medicine, 189(1), pp. 57–65. Available at: https://doi.org/10.1164/rccm.201305-0848OC.

N. Tester J., D. D. Fuller, J. S. Fromm, M. R. Spiess, A. L. Behrman, and J. H. Mateika, “Long-term facilitation of ventilation in humans with chronic spinal cord injury,” American Journal of Respiratory and Critical Care Medicine, vol. 189, no. 1, pp. 57–65, Jan. 2014, doi: 10.1164/rccm.201305-0848OC.

TESTER J., Nicole, David D. FULLER, Jason S. FROMM, Martina R. SPIESS, Andrea L. BEHRMAN und Jason H. MATEIKA, 2014. Long-term facilitation of ventilation in humans with chronic spinal cord injury. American Journal of Respiratory and Critical Care Medicine. Januar 2014. Bd. 189, Nr. 1, S. 57–65. DOI 10.1164/rccm.201305-0848OC

Tester J., Nicole, David D. Fuller, Jason S. Fromm, Martina R. Spiess, Andrea L. Behrman, and Jason H. Mateika. 2014. “Long-Term Facilitation of Ventilation in Humans with Chronic Spinal Cord Injury.” American Journal of Respiratory and Critical Care Medicine 189 (1): 57–65. https://doi.org/10.1164/rccm.201305-0848OC.

Tester J., Nicole, et al. “Long-Term Facilitation of Ventilation in Humans with Chronic Spinal Cord Injury.” American Journal of Respiratory and Critical Care Medicine, vol. 189, no. 1, Jan. 2014, pp. 57–65, https://doi.org/10.1164/rccm.201305-0848OC.