| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | Long-term facilitation of ventilation in humans with chronic spinal cord injury |
| Autor/-in: | Tester J., Nicole Fuller, David D. Fromm, Jason S. Spiess, Martina R. Behrman, Andrea L. Mateika, Jason H. |
| et. al: | No |
| DOI: | 10.1164/rccm.201305-0848OC |
| Erschienen in: | American Journal of Respiratory and Critical Care Medicine |
| Band(Heft): | 189 |
| Heft: | 1 |
| Seite(n): | 57 |
| Seiten bis: | 65 |
| Erscheinungsdatum: | Jan-2014 |
| Verlag / Hrsg. Institution: | American Thoracic Society |
| ISSN: | 1073-449X 1535-4970 |
| Sprache: | Englisch |
| Schlagwörter: | Adult; Aged; Female; Forced expiratory volume; Humans; Long-term care; Male; Middle aged; Respiratory mechanics; Respiratory therapy; Spinal cord Injury; Vital capacity; Hypoxia; Pulmonary ventilation; Respiration; Plasticity; Intermittent hypoxia |
| Fachgebiet (DDC): | 615: Pharmakologie und Therapeutik 617: Chirurgie |
| Zusammenfassung: | Rationale: Intermittent stimulation of the respiratory system with hypoxia causes persistent increases in respiratory motor output (i.e., long-term facilitation) in animals with spinal cord injury. This paradigm, therefore, has been touted as a potential respiratory rehabilitation strategy. Objectives: To determine whether acute (daily) exposure to intermittent hypoxia can also evoke long-term facilitation of ventilation after chronic spinal cord injury in humans, and whether repeated daily exposure to intermittent hypoxia enhances the magnitude of this response. Methods: Eight individuals with incomplete spinal cord injury (.1 yr; cervical [n = 6], thoracic [n = 2]) were exposed to intermittent hypoxia (eight 2-min intervals of 8% oxygen) for 10 days. During all exposures, end-tidal carbon dioxide levels were maintained, on average, 2 mm Hg above resting values. Minute ventilation, tidal volume, and breathing frequency were measured before (baseline), during, and 30 minutes after intermittent hypoxia. Sham protocols consisted of exposure to room air and were administered to a subset of the participants (n = 4). Measurements and Main Results: Minute ventilation increased significantly for 30 minutes after acute exposure to intermittent hypoxia (P , 0.001), but not after sham exposure. However, the magnitude of ventilatory long-term facilitation was not enhanced over 10 days of intermittent hypoxia exposures. Conclusions: Ventilatory long-term facilitation can be evoked by brief periods of hypoxia in humans with chronic spinal cord injury. Thus, intermittent hypoxia may represent a strategy for inducing respiratory neuroplasticity after declines in respiratory function that are related to neurological impairment. Clinical trial registered with www.clinicaltrials.gov (NCT01272011). |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/25562 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | Lizenz gemäss Verlagsvertrag |
| Departement: | Gesundheit |
| Organisationseinheit: | Institut für Ergotherapie (IER) |
| Enthalten in den Sammlungen: | Publikationen Gesundheit |
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Tester J., N., Fuller, D. D., Fromm, J. S., Spiess, M. R., Behrman, A. L., & Mateika, J. H. (2014). Long-term facilitation of ventilation in humans with chronic spinal cord injury. American Journal of Respiratory and Critical Care Medicine, 189(1), 57–65. https://doi.org/10.1164/rccm.201305-0848OC
Tester J., N. et al. (2014) ‘Long-term facilitation of ventilation in humans with chronic spinal cord injury’, American Journal of Respiratory and Critical Care Medicine, 189(1), pp. 57–65. Available at: https://doi.org/10.1164/rccm.201305-0848OC.
N. Tester J., D. D. Fuller, J. S. Fromm, M. R. Spiess, A. L. Behrman, and J. H. Mateika, “Long-term facilitation of ventilation in humans with chronic spinal cord injury,” American Journal of Respiratory and Critical Care Medicine, vol. 189, no. 1, pp. 57–65, Jan. 2014, doi: 10.1164/rccm.201305-0848OC.
TESTER J., Nicole, David D. FULLER, Jason S. FROMM, Martina R. SPIESS, Andrea L. BEHRMAN und Jason H. MATEIKA, 2014. Long-term facilitation of ventilation in humans with chronic spinal cord injury. American Journal of Respiratory and Critical Care Medicine. Januar 2014. Bd. 189, Nr. 1, S. 57–65. DOI 10.1164/rccm.201305-0848OC
Tester J., Nicole, David D. Fuller, Jason S. Fromm, Martina R. Spiess, Andrea L. Behrman, and Jason H. Mateika. 2014. “Long-Term Facilitation of Ventilation in Humans with Chronic Spinal Cord Injury.” American Journal of Respiratory and Critical Care Medicine 189 (1): 57–65. https://doi.org/10.1164/rccm.201305-0848OC.
Tester J., Nicole, et al. “Long-Term Facilitation of Ventilation in Humans with Chronic Spinal Cord Injury.” American Journal of Respiratory and Critical Care Medicine, vol. 189, no. 1, Jan. 2014, pp. 57–65, https://doi.org/10.1164/rccm.201305-0848OC.
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