Publication type: Conference other
Type of review: Peer review (abstract)
Title: Lymphopenia is highly prevalent in overt myelofibrosis at diagnosis but lacks additional prognostic value
Authors: Messerich, N.-M.
Cogliatti, S.
Lehmann, T.
Holbro, L.
Graf, R.
Benz, R.
Volken, T.
Silzle, T.
et. al: No
Published in: Swiss Medical Weekly
Proceedings: Abstracts of the Swiss Oncology & Hematology Congress (SOHC)
Volume(Issue): 151
Issue: Suppl. 255
Page(s): 32
Pages to: 33
Conference details: Swiss Oncology & Hematology Congress (SOHC), Zurich Airport, 18-20 November 2021
Issue Date: 18-Nov-2021
Publisher / Ed. Institution: EMH Swiss Medical Publishers
ISSN: 1424-7860
Language: English
Subjects: Lymphopenia; Myelofibrosis
Subject (DDC): 616: Internal medicine and diseases
Abstract: Background: Lymphopenia is prognostically relevant in several malignancies. Little is known about its role in myelofibrosis (MF). Aim: To evaluate the prevalence of lymphopenia at diagnosis and its prognostic impact in MF. Methods: Patients diagnosed between 2010-2020 at the Cantonal Hospitals St. Gallen and Muensterlingen with primary MF [PMF], MF secondary to essential thrombocytopenia or polycythemia vera [MF- post] and prefibrotic primary MF [pre- PMF] were evaluated for the absolute lymphocyte count (ALC) at diagnosis. Results: 80 patients with overt MF (PMF n = 59, MF-post n = 21) and 28 with pre-PMF were included. The ALC was lower in overt MF compared to pre-PMF (median 1.5x109/l versus 2.0x109/l, p = 0.039). In MF-post (evaluable post-ET n = 8, post-PV n = 10), a drop of the ALC was documented at MF-diagnosis compared to the diagnosis of the preceeding disorder (median 1.35x109/l versus 2.05x109/l, p = 0.009). An ALC <1.5x109/l was associated with lower hemoglobin concentration and neutrophil-counts (median 100 vs. 115g/l and 5.5 vs. 8 G/l, p = 0.009 and p = 0.023). For cases with fibrosis grade 3 versus grade 2, a trend towards a lower ALC was noted (median 1.3x109/l versus 1.6x109/l, p = 0.07). The DIPSS-groups did not differ with regard to the ALC. Neither an ALC <1.0x109/l nor <1.5x1.0x109/l was associated with a survival difference (median 65 versus 73 months, p = 0.879 and 66 versus 89 months, p = 0.823). Conclusions: Lymphopenia in MF is highly prevalent at diagnosis, but offers no additional prognostic information. Its association with lower hemoglobin values and the development of fibrosis in cases of MF-post points towards a possible relationship of lymphopenia with MF-pathophysiology.
Fulltext version: Published version
License (according to publishing contract): Licence according to publishing contract
Departement: School of Health Sciences
Organisational Unit: Institute of Public Health (IPH)
Appears in collections:Publikationen Gesundheit

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