Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Messerich, N.-M. | - |
dc.contributor.author | Cogliatti, S. | - |
dc.contributor.author | Lehmann, T. | - |
dc.contributor.author | Holbro, L. | - |
dc.contributor.author | Graf, R. | - |
dc.contributor.author | Benz, R. | - |
dc.contributor.author | Volken, T. | - |
dc.contributor.author | Silzle, T. | - |
dc.date.accessioned | 2022-04-28T13:18:46Z | - |
dc.date.available | 2022-04-28T13:18:46Z | - |
dc.date.issued | 2021-11-18 | - |
dc.identifier.issn | 1424-7860 | de_CH |
dc.identifier.uri | https://smw.ch/article/doi/SMW.2021.w30107 | de_CH |
dc.identifier.uri | https://digitalcollection.zhaw.ch/handle/11475/24896 | - |
dc.description.abstract | Background: Lymphopenia is prognostically relevant in several malignancies. Little is known about its role in myelofibrosis (MF). Aim: To evaluate the prevalence of lymphopenia at diagnosis and its prognostic impact in MF. Methods: Patients diagnosed between 2010-2020 at the Cantonal Hospitals St. Gallen and Muensterlingen with primary MF [PMF], MF secondary to essential thrombocytopenia or polycythemia vera [MF- post] and prefibrotic primary MF [pre- PMF] were evaluated for the absolute lymphocyte count (ALC) at diagnosis. Results: 80 patients with overt MF (PMF n = 59, MF-post n = 21) and 28 with pre-PMF were included. The ALC was lower in overt MF compared to pre-PMF (median 1.5x109/l versus 2.0x109/l, p = 0.039). In MF-post (evaluable post-ET n = 8, post-PV n = 10), a drop of the ALC was documented at MF-diagnosis compared to the diagnosis of the preceeding disorder (median 1.35x109/l versus 2.05x109/l, p = 0.009). An ALC <1.5x109/l was associated with lower hemoglobin concentration and neutrophil-counts (median 100 vs. 115g/l and 5.5 vs. 8 G/l, p = 0.009 and p = 0.023). For cases with fibrosis grade 3 versus grade 2, a trend towards a lower ALC was noted (median 1.3x109/l versus 1.6x109/l, p = 0.07). The DIPSS-groups did not differ with regard to the ALC. Neither an ALC <1.0x109/l nor <1.5x1.0x109/l was associated with a survival difference (median 65 versus 73 months, p = 0.879 and 66 versus 89 months, p = 0.823). Conclusions: Lymphopenia in MF is highly prevalent at diagnosis, but offers no additional prognostic information. Its association with lower hemoglobin values and the development of fibrosis in cases of MF-post points towards a possible relationship of lymphopenia with MF-pathophysiology. | de_CH |
dc.language.iso | en | de_CH |
dc.publisher | EMH Swiss Medical Publishers | de_CH |
dc.relation.ispartof | Swiss Medical Weekly | de_CH |
dc.rights | Licence according to publishing contract | de_CH |
dc.subject | Lymphopenia | de_CH |
dc.subject | Myelofibrosis | de_CH |
dc.subject.ddc | 616: Innere Medizin und Krankheiten | de_CH |
dc.title | Lymphopenia is highly prevalent in overt myelofibrosis at diagnosis but lacks additional prognostic value | de_CH |
dc.type | Konferenz: Sonstiges | de_CH |
dcterms.type | Text | de_CH |
zhaw.departement | Gesundheit | de_CH |
zhaw.organisationalunit | Institut für Public Health (IPH) | de_CH |
zhaw.conference.details | Swiss Oncology & Hematology Congress (SOHC), Zurich Airport, 18-20 November 2021 | de_CH |
zhaw.funding.eu | No | de_CH |
zhaw.issue | Suppl. 255 | de_CH |
zhaw.originated.zhaw | Yes | de_CH |
zhaw.pages.end | 33 | de_CH |
zhaw.pages.start | 32 | de_CH |
zhaw.publication.status | publishedVersion | de_CH |
zhaw.volume | 151 | de_CH |
zhaw.publication.review | Peer review (Abstract) | de_CH |
zhaw.title.proceedings | Abstracts of the Swiss Oncology & Hematology Congress (SOHC) | de_CH |
zhaw.author.additional | No | de_CH |
zhaw.display.portrait | Yes | de_CH |
Appears in collections: | Publikationen Gesundheit |
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Messerich, N.-M., Cogliatti, S., Lehmann, T., Holbro, L., Graf, R., Benz, R., Volken, T., & Silzle, T. (2021). Lymphopenia is highly prevalent in overt myelofibrosis at diagnosis but lacks additional prognostic value [Conference presentation]. Swiss Medical Weekly, 151(Suppl. 255), 32–33. https://smw.ch/article/doi/SMW.2021.w30107
Messerich, N.-M. et al. (2021) ‘Lymphopenia is highly prevalent in overt myelofibrosis at diagnosis but lacks additional prognostic value’, in Swiss Medical Weekly. EMH Swiss Medical Publishers, pp. 32–33. Available at: https://smw.ch/article/doi/SMW.2021.w30107.
N.-M. Messerich et al., “Lymphopenia is highly prevalent in overt myelofibrosis at diagnosis but lacks additional prognostic value,” in Swiss Medical Weekly, Nov. 2021, vol. 151, no. Suppl. 255, pp. 32–33. [Online]. Available: https://smw.ch/article/doi/SMW.2021.w30107
MESSERICH, N.-M., S. COGLIATTI, T. LEHMANN, L. HOLBRO, R. GRAF, R. BENZ, T. VOLKEN und T. SILZLE, 2021. Lymphopenia is highly prevalent in overt myelofibrosis at diagnosis but lacks additional prognostic value. In: Swiss Medical Weekly [online]. Conference presentation. EMH Swiss Medical Publishers. 18 November 2021. S. 32–33. Verfügbar unter: https://smw.ch/article/doi/SMW.2021.w30107
Messerich, N.-M., S. Cogliatti, T. Lehmann, L. Holbro, R. Graf, R. Benz, T. Volken, and T. Silzle. 2021. “Lymphopenia Is Highly Prevalent in Overt Myelofibrosis at Diagnosis but Lacks Additional Prognostic Value.” Conference presentation. In Swiss Medical Weekly, 151:32–33. EMH Swiss Medical Publishers. https://smw.ch/article/doi/SMW.2021.w30107.
Messerich, N.-M., et al. “Lymphopenia Is Highly Prevalent in Overt Myelofibrosis at Diagnosis but Lacks Additional Prognostic Value.” Swiss Medical Weekly, vol. 151, no. Suppl. 255, EMH Swiss Medical Publishers, 2021, pp. 32–33, https://smw.ch/article/doi/SMW.2021.w30107.
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