Publication type: Contribution to magazine or newspaper
Title: How to efficiently shake viscous culture broths
Authors: Meister, Jolanda
Maschke, Rüdiger
Werner, Sören
Eibl, Dieter
John, Gernot T.
et. al: No
Published in: Genetic Engineering & Biotechnology News
Volume(Issue): 36
Issue: 15
Issue Date: 1-Sep-2016
Publisher / Ed. Institution: Mary Ann Liebert
ISSN: 1937-8661
Language: English
Subjects: Shake flask; Thomson Optimum Growth; kLa; Viscosity
Subject (DDC): 660.6: Biotechnology
Abstract: In biotechnology, the use of shake flasks is widespread due to their easy handling, especially in process design and optimization as well as in small-scale upstream processing and inoculum production. Recently, geometrically optimized Thomson Optimum Growth™ shake flasks were introduced to the market, promoting higher yields with the same shaker footprint. Knowledge of different engineering parameters (including the oxygen mass transfer coefficient, the mixing time, or the power consumption) is essential to compare these new flasks with established shake flasks and to evaluate potential benefits. In the present work, the oxygen mass transfer in Thomson Optimum Growth disposable shake flasks is quantified at 500 mL and 5 L using the PreSens Shake Flask Reader.
Fulltext version: Published version
License (according to publishing contract): Licence according to publishing contract
Departement: Life Sciences and Facility Management
Organisational Unit: Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:Publikationen Life Sciences und Facility Management

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