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Title: Physiological responses of carp (Cyprinus carpio L.) to dietary exposure to zearalenone (ZEN)
Authors : Pietsch-Schmied, Constanze
Junge, Ranka
Published in : Comparative Biochemistry and Physiology. Part C : Toxicology & Pharmacology
Volume(Issue) : 188
Pages : 52
Pages to: 59
Publisher / Ed. Institution : Elsevier Inc.
Issue Date: Oct-2016
License (according to publishing contract) : Licence according to publishing contract
Type of review: Peer review (Publication)
Language : English
Subjects : Mycotoxin; Physiological stress; Carp; Metabolic costs
Subject (DDC) : 572: Biochemistry
Abstract: Zearalenone (ZEN) is a frequent contaminant of animal feeds, but systemic effects on fish and possible metabolic costs have not yet been investigated. In order to fill this gap a feeding trial with juvenile carpwas conducted. The fish were fed ZEN-contaminated diets at three concentrations (low: 332 μg kg−1, medium: 621 μg kg−1, and high: 797 μg kg−1 final feed, respectively) for four weeks. Possible reversible effects of ZEN were evaluated by feeding an additional group with the mycotoxin for four weeks period and the  uncontaminated diet for further two weeks. After that possible ZEN effects on enzyme activities in kidney, spleen, liver and muscle tissue were investigated to get an organism-wide aspect of ZEN effects.Most organs appeared to (over)compensate ZEN effects during the exposure to this mycotoxin,which causedmetabolic costs. Oxygen consumption increased in fish treated with the two higher ZEN concentrations via the diet. The differences between the treatments persisted also after the recovery phase of two weeks. Thus, the present study provided evidence of effects of ZEN on carbohydrate metabolism, lipid peroxidation in organs and metabolic oxygen demand. This is the first evidence for increased metabolic costs in a fish species due to exposure to the mycotoxin ZEN.
Departement: Life Sciences and Facility Management
Organisational Unit: Institute of Natural Resource Sciences (IUNR)
Publication type: Article in scientific Journal
DOI : 10.1016/j.cbpc.2016.06.004
ISSN: 1532-0456
Appears in Collections:Publikationen Life Sciences und Facility Management

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