Title: Disposable bioreactors II
Editors: Eibl, Dieter
Eibl-Schindler, Regine
Extent : 292
Publisher / Ed. Institution : Springer
Publisher / Ed. Institution: Berlin
Issue Date: 2013
License (according to publishing contract) : Licence according to publishing contract
Series : Advances in Biochemical Engineering/Biotechnology
Series volume: 138
Type of review: Not specified
Language : English
Subjects : Computational fluid dynamics; Engineering characteristics; Scale-up; Single-use bioreactor
Subject (DDC) : 660: Chemical engineering
Abstract: During the past 10 years, single-use bioreactors have been well accepted in modern biopharmaceutical production processes targeting high-value products. Up to now, such processes have mainly been small- or medium-scale mammalian cell culture-based seed inoculum, vaccine or antibody productions. However, recently first attempts have been made to modify existing single-use bioreactors for the cultivation of plant cells and tissue cultures, and microorganisms. This has even led to the development of new single-use bioreactor types. Moreover, due to safety issues it has become clear that single-use bioreactors are the “must have” for expanding human stem cells delivering cell therapeutics, the biopharmaceuticals of the next generation. So it comes as no surprise that numerous different dynamic single-use bioreactor types, which are suitable for a wide range of applications, already dominate the market today. Bioreactor working principles, main applications, and bioengineering data are presented in this review, based on a current overview of greater than milliliter-scale, commercially available, dynamic single-use bioreactors. The focus is on stirred versions, which are omnipresent in R&D and manufacturing, and in particular Sartorius Stedim’s BIOSTAT family. Finally, we examine development trends for single-use bioreactors, after discussing proven approaches for fast scaling-up processes.
Departement: Life Sciences und Facility Management
Organisational Unit: Institute of Chemistry and Biotechnology (ICBT)
Publication type: Book
DOI : 10.1007/978-3-642-45158-4
ISBN: 978-3-642-45157-7
URI: https://digitalcollection.zhaw.ch/handle/11475/2340
Appears in Collections:Publikationen Life Sciences und Facility Management

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