Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Eibl-Schindler, Regine | - |
dc.contributor.author | Steiger, Nina | - |
dc.contributor.author | Wellnitz, Sabine | - |
dc.contributor.author | Vicente, Tiago | - |
dc.contributor.author | John, Corinne | - |
dc.contributor.author | Eibl, Dieter | - |
dc.date.accessioned | 2018-01-29T15:11:51Z | - |
dc.date.available | 2018-01-29T15:11:51Z | - |
dc.date.issued | 2014 | - |
dc.identifier.isbn | 978-3-642-45157-7 | de_CH |
dc.identifier.isbn | 978-3-642-45158-4 | de_CH |
dc.identifier.uri | https://digitalcollection.zhaw.ch/handle/11475/2254 | - |
dc.description.abstract | During the last few years virus like particles (VLPs) have become increasingly interesting for the production of vaccines. This development is explained by their excellent safety profile as well as a significant number of clinical studies showing strong and long-lasting protection. A further reason is the possibility of speeding up VLP vaccine manufacturing by implementing single-use (SU) technology in the case of mammalian and insect-cell-based processes, for which a multitude of SU devices up to middle-volume scale already exist. After briefly introducing the vaccine types and expression systems currently in use, this chapter turns to VLP vaccines and the insect cell/baculovirus expression vector system (IC/BEVS). Based on the main process characteristics and typical process flow of IC/BEVS-based VLP vaccine productions, suitable SU devices and their implementation are addressed. We subsequently report on the successful development of a fast, scalable benchtop production process generating a four-protein component influenza A H1N1 VLP vaccine candidate. This process is based on Spodoptera frugiperda (Sf)-9 cells and combines Redbiotec’s rePAXTM technology with obtainable SU devices for upstream (USP) and downstream processing (DSP). | de_CH |
dc.language.iso | en | de_CH |
dc.publisher | Springer | de_CH |
dc.relation.ispartof | Disposable bioreactors II | de_CH |
dc.relation.ispartofseries | Advances in Biochemical Engineering/Biotechnology | de_CH |
dc.rights | Licence according to publishing contract | de_CH |
dc.subject | DSP | de_CH |
dc.subject | Influenza | de_CH |
dc.subject | VLP vaccine | de_CH |
dc.subject | Sf-9/BEVS USP | de_CH |
dc.subject | Wave-mixed bioreactor | de_CH |
dc.subject.ddc | 615: Pharmakologie und Therapeutik | de_CH |
dc.title | Fast single-use VLP vaccine productions based on insect cells and the baculovirus expression vector system : influenza as case study | de_CH |
dc.type | Buchbeitrag | de_CH |
dcterms.type | Text | de_CH |
zhaw.departement | Life Sciences und Facility Management | de_CH |
zhaw.organisationalunit | Institut für Chemie und Biotechnologie (ICBT) | de_CH |
zhaw.publisher.place | Berlin | de_CH |
dc.identifier.doi | 10.1007/10_2013_186 | de_CH |
zhaw.funding.eu | No | de_CH |
zhaw.originated.zhaw | Yes | de_CH |
zhaw.pages.end | 125 | de_CH |
zhaw.pages.start | 99 | de_CH |
zhaw.parentwork.editor | Eibl, Dieter | - |
zhaw.parentwork.editor | Eibl-Schindler, Regine | - |
zhaw.publication.status | publishedVersion | de_CH |
zhaw.series.number | 138 | de_CH |
zhaw.publication.review | Editorial review | de_CH |
Appears in collections: | Publikationen Life Sciences und Facility Management |
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Eibl-Schindler, R., Steiger, N., Wellnitz, S., Vicente, T., John, C., & Eibl, D. (2014). Fast single-use VLP vaccine productions based on insect cells and the baculovirus expression vector system : influenza as case study. In D. Eibl & R. Eibl-Schindler (Eds.), Disposable bioreactors II (pp. 99–125). Springer. https://doi.org/10.1007/10_2013_186
Eibl-Schindler, R. et al. (2014) ‘Fast single-use VLP vaccine productions based on insect cells and the baculovirus expression vector system : influenza as case study’, in D. Eibl and R. Eibl-Schindler (eds) Disposable bioreactors II. Berlin: Springer, pp. 99–125. Available at: https://doi.org/10.1007/10_2013_186.
R. Eibl-Schindler, N. Steiger, S. Wellnitz, T. Vicente, C. John, and D. Eibl, “Fast single-use VLP vaccine productions based on insect cells and the baculovirus expression vector system : influenza as case study,” in Disposable bioreactors II, D. Eibl and R. Eibl-Schindler, Eds. Berlin: Springer, 2014, pp. 99–125. doi: 10.1007/10_2013_186.
EIBL-SCHINDLER, Regine, Nina STEIGER, Sabine WELLNITZ, Tiago VICENTE, Corinne JOHN und Dieter EIBL, 2014. Fast single-use VLP vaccine productions based on insect cells and the baculovirus expression vector system : influenza as case study. In: Dieter EIBL und Regine EIBL-SCHINDLER (Hrsg.), Disposable bioreactors II. Berlin: Springer. S. 99–125. ISBN 978-3-642-45157-7
Eibl-Schindler, Regine, Nina Steiger, Sabine Wellnitz, Tiago Vicente, Corinne John, and Dieter Eibl. 2014. “Fast Single-Use VLP Vaccine Productions Based on Insect Cells and the Baculovirus Expression Vector System : Influenza as Case Study.” In Disposable Bioreactors II, edited by Dieter Eibl and Regine Eibl-Schindler, 99–125. Berlin: Springer. https://doi.org/10.1007/10_2013_186.
Eibl-Schindler, Regine, et al. “Fast Single-Use VLP Vaccine Productions Based on Insect Cells and the Baculovirus Expression Vector System : Influenza as Case Study.” Disposable Bioreactors II, edited by Dieter Eibl and Regine Eibl-Schindler, Springer, 2014, pp. 99–125, https://doi.org/10.1007/10_2013_186.
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