Title: Innovative, non-stirred bioreactors in scales form milliliters up to 1000 L for suspension cultures of cells using disposable bags and containers - a Swiss contribution
Authors : Werner, Sören
Eibl-Schindler, Regine
Lettenbauer, Christine
Röll, Marcel
Eibl, Dieter
De Jesus, Maria
Zhang, Xiaowei
Stettler, Matthieu
Tissot, Stephanie
Bürkie, Cedric
Broccard, Gilles
Kühner, Markus
Tanner, Rolf
Baldi, Lucia
Hacker, David
Wurm, Florian M.
Published in : CHIMIA International Journal for Chemistry
Volume(Issue) : 64
Issue : 11
Pages : 819
Pages to: 823
Publisher / Ed. Institution : Swiss Chemical Society
Publisher / Ed. Institution: Bern
Issue Date: Nov-2010
License (according to publishing contract) : Licence according to publishing contract
Type of review: Peer review (Publication)
Language : English
Subjects : Disposable bioreactors; Engineering characteristics; High density cho cultures; Orbitally shaken; Wave mixed
Subject (DDC) : 660: Chemical engineering
Abstract: Innovative mixing principles in bioreactors, for example using the rocking of a platform to induce a backwards and forwards 'wave', or using orbital shaking to generate a 'wave' that runs round in a cylindrical container, have proved to be successful for the suspension cultures of cells, especially when combined with disposable materials. This article presents an overview of the engineering characteristics when these new principles are applied in bioreactors, and case studies covering scales of operation from milliliters to 1000 Liters.
Departement: Life Sciences and Facility Management
Organisational Unit: Institute of Chemistry and Biotechnology (ICBT)
Publication type: Article in scientific Journal
DOI : 10.2533/chimia.2010.819
ISSN: 0009-4293
URI: https://digitalcollection.zhaw.ch/handle/11475/2251
Appears in Collections:Publikationen Life Sciences und Facility Management

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