| Title: | Innovative, non-stirred bioreactors in scales form milliliters up to 1000 L for suspension cultures of cells using disposable bags and containers - a Swiss contribution |
| Authors : | Werner, Sören Eibl-Schindler, Regine Lettenbauer, Christine Röll, Marcel Eibl, Dieter De Jesus, Maria Zhang, Xiaowei Stettler, Matthieu Tissot, Stephanie Bürkie, Cedric Broccard, Gilles Kühner, Markus Tanner, Rolf Baldi, Lucia Hacker, David Wurm, Florian M. |
| Published in : | CHIMIA International Journal for Chemistry |
| Volume(Issue) : | 64 |
| Issue : | 11 |
| Pages : | 819 |
| Pages to: | 823 |
| Publisher / Ed. Institution : | Swiss Chemical Society |
| Publisher / Ed. Institution: | Bern |
| Issue Date: | Nov-2010 |
| License (according to publishing contract) : | Licence according to publishing contract |
| Type of review: | Peer review (Publication) |
| Language : | English |
| Subjects : | Disposable bioreactors; Engineering characteristics; High density cho cultures; Orbitally shaken; Wave mixed |
| Subject (DDC) : | 660: Chemical engineering |
| Abstract: | Innovative mixing principles in bioreactors, for example using the rocking of a platform to induce a backwards and forwards 'wave', or using orbital shaking to generate a 'wave' that runs round in a cylindrical container, have proved to be successful for the suspension cultures of cells, especially when combined with disposable materials. This article presents an overview of the engineering characteristics when these new principles are applied in bioreactors, and case studies covering scales of operation from milliliters to 1000 Liters. |
| Departement: | Life Sciences and Facility Management |
| Organisational Unit: | Institute of Chemistry and Biotechnology (ICBT) |
| Publication type: | Article in scientific Journal |
| DOI : | 10.2533/chimia.2010.819 |
| ISSN: | 0009-4293 |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/2251 |
| Appears in Collections: | Publikationen Life Sciences und Facility Management |
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