Publication type: | Article in scientific journal |
Type of review: | Peer review (publication) |
Title: | Course of psychotic symptoms, depression and global functioning in persons at clinical high risk of psychosis : results of a longitudinal observation study over three years focusing on both converters and non-converters |
Authors: | Hengartner, Michael Pascal Heekeren, Karsten Dvorsky, Diane Walitza, Susanne Rössler, Wulf Theodoridou, Anastasia |
DOI: | 10.1016/j.schres.2017.01.040 |
Published in: | Schizophrenia Research |
Volume(Issue): | 189 |
Page(s): | 19 |
Pages to: | 26 |
Issue Date: | Nov-2017 |
Publisher / Ed. Institution: | Elsevier |
ISSN: | 0920-9964 1573-2509 |
Language: | English |
Subject (DDC): | 616.89: Mental disorders, clinical psychology and psychiatry |
Abstract: | The aim of this study was to test the validity of the CHR state by focusing on the course of psychosis spectrum symptoms, depression and global functioning in converters and non-converters. A total of 188 CHR-positive subjects (60.2% men) aged between 13 and 35 years (mean = 20.5) at study outset were assessed five times (t0-t4) over a total observation period of 36 months. Conversion to manifest psychosis was defined according to ICD-10 criteria for schizophrenia (F20) or brief psychotic disorder (F23). Measures of positive and negative symptoms were assessed with the Structured Interview for Prodromal Syndromes (SIPS), depression with the Calgary Depression Scale (CDS), and global functioning with the Global Assessment of Functioning Scale (GAF). Converters scored higher over time on all SIPS scales apart from grandiosity (Cohen's d: 0.5-0.7; all p < 0.001), higher on the CDS (d = 0.43, p = 0.001) and lower on the GAF (d = 0.69, p < 0.001) than did non-converters. Positive and negative symptoms as well as depression were most severe at study outset (t0) and then declined sharply following a linear function over the three-year observation period (t1-t4) across groups (all linear contrasts p < 0.001). In conclusion, converters showed significantly more psychopathological symptoms and poorer functioning before crossing the diagnostic threshold for manifest psychosis. CHR-subjects who convert to manifest psychosis during follow-up appear to be recovering from illness rather than becoming ill. Major issues involve the poor discrimination of CHR state and psychosis as well as the dichotomous definition of both at-risk and disease states. Further examination in other CHR-samples is warranted. |
URI: | https://digitalcollection.zhaw.ch/handle/11475/2243 |
Fulltext version: | Published version |
License (according to publishing contract): | Licence according to publishing contract |
Departement: | Applied Psychology |
Organisational Unit: | Psychological Institute (PI) |
Appears in collections: | Publikationen Angewandte Psychologie |
Files in This Item:
There are no files associated with this item.
Show full item record
Hengartner, M. P., Heekeren, K., Dvorsky, D., Walitza, S., Rössler, W., & Theodoridou, A. (2017). Course of psychotic symptoms, depression and global functioning in persons at clinical high risk of psychosis : results of a longitudinal observation study over three years focusing on both converters and non-converters. Schizophrenia Research, 189, 19–26. https://doi.org/10.1016/j.schres.2017.01.040
Hengartner, M.P. et al. (2017) ‘Course of psychotic symptoms, depression and global functioning in persons at clinical high risk of psychosis : results of a longitudinal observation study over three years focusing on both converters and non-converters’, Schizophrenia Research, 189, pp. 19–26. Available at: https://doi.org/10.1016/j.schres.2017.01.040.
M. P. Hengartner, K. Heekeren, D. Dvorsky, S. Walitza, W. Rössler, and A. Theodoridou, “Course of psychotic symptoms, depression and global functioning in persons at clinical high risk of psychosis : results of a longitudinal observation study over three years focusing on both converters and non-converters,” Schizophrenia Research, vol. 189, pp. 19–26, Nov. 2017, doi: 10.1016/j.schres.2017.01.040.
HENGARTNER, Michael Pascal, Karsten HEEKEREN, Diane DVORSKY, Susanne WALITZA, Wulf RÖSSLER und Anastasia THEODORIDOU, 2017. Course of psychotic symptoms, depression and global functioning in persons at clinical high risk of psychosis : results of a longitudinal observation study over three years focusing on both converters and non-converters. Schizophrenia Research. November 2017. Bd. 189, S. 19–26. DOI 10.1016/j.schres.2017.01.040
Hengartner, Michael Pascal, Karsten Heekeren, Diane Dvorsky, Susanne Walitza, Wulf Rössler, and Anastasia Theodoridou. 2017. “Course of Psychotic Symptoms, Depression and Global Functioning in Persons at Clinical High Risk of Psychosis : Results of a Longitudinal Observation Study over Three Years Focusing on Both Converters and Non-Converters.” Schizophrenia Research 189 (November): 19–26. https://doi.org/10.1016/j.schres.2017.01.040.
Hengartner, Michael Pascal, et al. “Course of Psychotic Symptoms, Depression and Global Functioning in Persons at Clinical High Risk of Psychosis : Results of a Longitudinal Observation Study over Three Years Focusing on Both Converters and Non-Converters.” Schizophrenia Research, vol. 189, Nov. 2017, pp. 19–26, https://doi.org/10.1016/j.schres.2017.01.040.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.