Publication type: | Article in scientific journal |
Type of review: | Peer review (publication) |
Title: | Investigations on mechanical stress caused to CHO suspension cells by standard and single-use pumps |
Authors: | Blaschczok, Katharina Kaiser, Stephan C. Löffelholz, Christian Imseng, Nicole Burkart, Jürg Bösch, Pascal Dornfeld, Wolfgang Eibl-Schindler, Regine Eibl, Dieter |
DOI: | 10.1002/cite.201200135 |
Published in: | Chemie Ingenieur Technik |
Volume(Issue): | 85 |
Issue: | 1-2 |
Page(s): | 144 |
Pages to: | 152 |
Issue Date: | Feb-2013 |
Publisher / Ed. Institution: | Wiley |
Publisher / Ed. Institution: | Weinheim |
ISSN: | 0009-286X 1522-2640 |
Language: | English |
Subject (DDC): | 620: Engineering |
Abstract: | Mechanical stress caused to transfected Chinese hamster ovary (CHO) suspension cells by reusable and single-use magnetically levitated, bearingless centrifugal pumps was investigated. Cell death rates were determined for different pump speeds and compared with data from a peristaltic and a 4-piston diaphragm pump. Furthermore, the fluid distribution inside the PuraLev® 200 pump was modeled using computational fluid dynamics. The results reveal considerably lower mechanical stress to CHO cells caused by the magnetically levitated bearingless centrifugal pumps than by the peristaltic and diaphragm pump. |
URI: | https://digitalcollection.zhaw.ch/handle/11475/2242 |
Fulltext version: | Published version |
License (according to publishing contract): | Licence according to publishing contract |
Departement: | Life Sciences and Facility Management |
Organisational Unit: | Institute of Chemistry and Biotechnology (ICBT) |
Appears in collections: | Publikationen Life Sciences und Facility Management |
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Blaschczok, K., Kaiser, S. C., Löffelholz, C., Imseng, N., Burkart, J., Bösch, P., Dornfeld, W., Eibl-Schindler, R., & Eibl, D. (2013). Investigations on mechanical stress caused to CHO suspension cells by standard and single-use pumps. Chemie Ingenieur Technik, 85(1-2), 144–152. https://doi.org/10.1002/cite.201200135
Blaschczok, K. et al. (2013) ‘Investigations on mechanical stress caused to CHO suspension cells by standard and single-use pumps’, Chemie Ingenieur Technik, 85(1-2), pp. 144–152. Available at: https://doi.org/10.1002/cite.201200135.
K. Blaschczok et al., “Investigations on mechanical stress caused to CHO suspension cells by standard and single-use pumps,” Chemie Ingenieur Technik, vol. 85, no. 1-2, pp. 144–152, Feb. 2013, doi: 10.1002/cite.201200135.
BLASCHCZOK, Katharina, Stephan C. KAISER, Christian LÖFFELHOLZ, Nicole IMSENG, Jürg BURKART, Pascal BÖSCH, Wolfgang DORNFELD, Regine EIBL-SCHINDLER und Dieter EIBL, 2013. Investigations on mechanical stress caused to CHO suspension cells by standard and single-use pumps. Chemie Ingenieur Technik. Februar 2013. Bd. 85, Nr. 1-2, S. 144–152. DOI 10.1002/cite.201200135
Blaschczok, Katharina, Stephan C. Kaiser, Christian Löffelholz, Nicole Imseng, Jürg Burkart, Pascal Bösch, Wolfgang Dornfeld, Regine Eibl-Schindler, and Dieter Eibl. 2013. “Investigations on Mechanical Stress Caused to CHO Suspension Cells by Standard and Single-Use Pumps.” Chemie Ingenieur Technik 85 (1-2): 144–52. https://doi.org/10.1002/cite.201200135.
Blaschczok, Katharina, et al. “Investigations on Mechanical Stress Caused to CHO Suspension Cells by Standard and Single-Use Pumps.” Chemie Ingenieur Technik, vol. 85, no. 1-2, Feb. 2013, pp. 144–52, https://doi.org/10.1002/cite.201200135.
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