| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | An approach for scale-up of geometrically dissimilar orbitally shaken single-use bioreactors |
| Autor/-in: | Werner, Sören Olownia, Johanna Egger, Daniel Eibl, Dieter |
| DOI: | 10.1002/cite.201200153 |
| Erschienen in: | Chemie Ingenieur Technik |
| Band(Heft): | 85 |
| Heft: | 1-2 |
| Seite(n): | 118 |
| Seiten bis: | 126 |
| Erscheinungsdatum: | Feb-2013 |
| Verlag / Hrsg. Institution: | Wiley |
| Verlag / Hrsg. Institution: | Weinheim |
| ISSN: | 0009-286X 1522-2640 |
| Sprache: | Englisch |
| Fachgebiet (DDC): | 660: Technische Chemie |
| Zusammenfassung: | An initial approach for scaling up geometrically dissimilar orbitally shaken bioreactors is presented. A novel ShakerBag Option for Multitron Cell shaking incubators allows a rapid increase in working volume from small TubeSpin bioreactors or shake flasks up to 10 L, thus offering a simple and cost-efficient alternative to present systems for scale-up. The engineering parameters for scale-up of the orbitally shaken single-use bags were determined using traditional methods. Modern computational fluid dynamics based methods were used to gain a deeper insight into the fluid flow behavior. Furthermore, mass propagation of plant cell suspensions (Nicotiana tabacum and Vitis vinifera), as well as cell expansion and production of protein complexes using insect cells (Sf-9), show the potential of orbitally shaken single-use bags. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/2241 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | Lizenz gemäss Verlagsvertrag |
| Departement: | Life Sciences und Facility Management |
| Organisationseinheit: | Institut für Chemie und Biotechnologie (ICBT) |
| Enthalten in den Sammlungen: | Publikationen Life Sciences und Facility Management |
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Werner, S., Olownia, J., Egger, D., & Eibl, D. (2013). An approach for scale-up of geometrically dissimilar orbitally shaken single-use bioreactors. Chemie Ingenieur Technik, 85(1-2), 118–126. https://doi.org/10.1002/cite.201200153
Werner, S. et al. (2013) ‘An approach for scale-up of geometrically dissimilar orbitally shaken single-use bioreactors’, Chemie Ingenieur Technik, 85(1-2), pp. 118–126. Available at: https://doi.org/10.1002/cite.201200153.
S. Werner, J. Olownia, D. Egger, and D. Eibl, “An approach for scale-up of geometrically dissimilar orbitally shaken single-use bioreactors,” Chemie Ingenieur Technik, vol. 85, no. 1-2, pp. 118–126, Feb. 2013, doi: 10.1002/cite.201200153.
WERNER, Sören, Johanna OLOWNIA, Daniel EGGER und Dieter EIBL, 2013. An approach for scale-up of geometrically dissimilar orbitally shaken single-use bioreactors. Chemie Ingenieur Technik. Februar 2013. Bd. 85, Nr. 1-2, S. 118–126. DOI 10.1002/cite.201200153
Werner, Sören, Johanna Olownia, Daniel Egger, and Dieter Eibl. 2013. “An Approach for Scale-up of Geometrically Dissimilar Orbitally Shaken Single-Use Bioreactors.” Chemie Ingenieur Technik 85 (1-2): 118–26. https://doi.org/10.1002/cite.201200153.
Werner, Sören, et al. “An Approach for Scale-up of Geometrically Dissimilar Orbitally Shaken Single-Use Bioreactors.” Chemie Ingenieur Technik, vol. 85, no. 1-2, Feb. 2013, pp. 118–26, https://doi.org/10.1002/cite.201200153.
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