An approach for scale-up of geometrically dissimilar orbitally shaken single-use bioreactors

Werner, Sören; Olownia, Johanna; Egger, Daniel; Eibl, Dieter

doi:10.1002/cite.201200153

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	An approach for scale-up of geometrically dissimilar orbitally shaken single-use bioreactors
Authors:	Werner, Sören Olownia, Johanna Egger, Daniel Eibl, Dieter
DOI:	10.1002/cite.201200153
Published in:	Chemie Ingenieur Technik
Volume(Issue):	85
Issue:	1-2
Page(s):	118
Pages to:	126
Issue Date:	Feb-2013
Publisher / Ed. Institution:	Wiley
Publisher / Ed. Institution:	Weinheim
ISSN:	0009-286X 1522-2640
Language:	English
Subject (DDC):	660: Chemical engineering
Abstract:	An initial approach for scaling up geometrically dissimilar orbitally shaken bioreactors is presented. A novel ShakerBag Option for Multitron Cell shaking incubators allows a rapid increase in working volume from small TubeSpin bioreactors or shake flasks up to 10 L, thus offering a simple and cost-efficient alternative to present systems for scale-up. The engineering parameters for scale-up of the orbitally shaken single-use bags were determined using traditional methods. Modern computational fluid dynamics based methods were used to gain a deeper insight into the fluid flow behavior. Furthermore, mass propagation of plant cell suspensions (Nicotiana tabacum and Vitis vinifera), as well as cell expansion and production of protein complexes using insect cells (Sf-9), show the potential of orbitally shaken single-use bags.
URI:	https://digitalcollection.zhaw.ch/handle/11475/2241
Fulltext version:	Published version
License (according to publishing contract):	Licence according to publishing contract
Departement:	Life Sciences and Facility Management
Organisational Unit:	Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:	Publikationen Life Sciences und Facility Management

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Werner, S., Olownia, J., Egger, D., & Eibl, D. (2013). An approach for scale-up of geometrically dissimilar orbitally shaken single-use bioreactors. Chemie Ingenieur Technik, 85(1-2), 118–126. https://doi.org/10.1002/cite.201200153

Werner, S. et al. (2013) ‘An approach for scale-up of geometrically dissimilar orbitally shaken single-use bioreactors’, Chemie Ingenieur Technik, 85(1-2), pp. 118–126. Available at: https://doi.org/10.1002/cite.201200153.

S. Werner, J. Olownia, D. Egger, and D. Eibl, “An approach for scale-up of geometrically dissimilar orbitally shaken single-use bioreactors,” Chemie Ingenieur Technik, vol. 85, no. 1-2, pp. 118–126, Feb. 2013, doi: 10.1002/cite.201200153.

WERNER, Sören, Johanna OLOWNIA, Daniel EGGER und Dieter EIBL, 2013. An approach for scale-up of geometrically dissimilar orbitally shaken single-use bioreactors. Chemie Ingenieur Technik. Februar 2013. Bd. 85, Nr. 1-2, S. 118–126. DOI 10.1002/cite.201200153

Werner, Sören, Johanna Olownia, Daniel Egger, and Dieter Eibl. 2013. “An Approach for Scale-up of Geometrically Dissimilar Orbitally Shaken Single-Use Bioreactors.” Chemie Ingenieur Technik 85 (1-2): 118–26. https://doi.org/10.1002/cite.201200153.

Werner, Sören, et al. “An Approach for Scale-up of Geometrically Dissimilar Orbitally Shaken Single-Use Bioreactors.” Chemie Ingenieur Technik, vol. 85, no. 1-2, Feb. 2013, pp. 118–26, https://doi.org/10.1002/cite.201200153.