|Title:||Development of the travelling wave bioreactor. Part II : engineering characteristics and cultivation results|
|Authors :||Kaiser, Stephan|
|Published in :||Chemie Ingenieur Technik|
|Publisher / Ed. Institution :||Wiley VCH|
|Publisher / Ed. Institution:||Weinheim|
|Language :||Englisch / English|
|Subject (DDC) :||660: Technische Chemie|
|Abstract:||The innovative travelling wave bioreactor (TWB), an orbitally shaken system, developed specifically for cell culture applications, is investigated. In this study, engineering parameters covering power input, mixing time and oxygen mass transfer obtained in two TWB prototypes are presented for the first time. Based on the results, cultivation parameters for CHO suspension cell cultivations were defined. Cell growth and substrate consumption were comparable with a wave-mixed reference bioreactor, which demonstrates the bioreactor's applicability for cultivations of mammalian cell cultures for the first time.|
|Departement:||Life Sciences und Facility Management|
|Publication type:||Beitrag in wissenschaftlicher Zeitschrift / Article in scientific Journal|
|Type of review:||Peer review (Publikation)|
|License (according to publishing contract) :||Lizenz gemäss Verlagsvertrag / Licence according to publishing contract|
|Appears in Collections:||Publikationen Life Sciences und Facility Management|
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