Title: Development of the travelling wave bioreactor. Part II : engineering characteristics and cultivation results
Authors : Kaiser, Stephan
Perepelitsa, Nadja
Kraume, Matthias
Eibl, Dieter
Published in : Chemie Ingenieur Technik
Volume(Issue) : 88
Issue : 1-2
Pages : 86
Pages to: 92
Publisher / Ed. Institution : Wiley VCH
Publisher / Ed. Institution: Weinheim
Issue Date: Feb-2016
License (according to publishing contract) : Licence according to publishing contract
Type of review: Peer review (Publication)
Language : English
Subject (DDC) : 660: Chemical engineering
Abstract: The innovative travelling wave bioreactor (TWB), an orbitally shaken system, developed specifically for cell culture applications, is investigated. In this study, engineering parameters covering power input, mixing time and oxygen mass transfer obtained in two TWB prototypes are presented for the first time. Based on the results, cultivation parameters for CHO suspension cell cultivations were defined. Cell growth and substrate consumption were comparable with a wave-mixed reference bioreactor, which demonstrates the bioreactor's applicability for cultivations of mammalian cell cultures for the first time.
Departement: Life Sciences und Facility Management
Publication type: Article in scientific Journal
DOI : 10.1002/cite.201500091
ISSN: 0009-286X
URI: https://digitalcollection.zhaw.ch/handle/11475/2229
Appears in Collections:Publikationen Life Sciences und Facility Management

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