Publication type: Article in scientific journal
Type of review: Peer review (publication)
Title: Cognitive function in association with high estradiol levels resulting from fertility treatment
Authors: Leeners, Brigitte
Krüger, Tillmann
Geraedts, Kirsten
Tronci, Enrico
Mancini, Toni
Ille, Fabian
Egli, Marcel
Röblitz, Susanna
Wunder, Dorothea
Saleh, Lanja
Schippert, Cordula
Hengartner, Michael Pascal
et. al: No
DOI: 10.1016/j.yhbeh.2021.104951
Published in: Hormones and Behavior
Volume(Issue): 130
Issue Date: 2021
Publisher / Ed. Institution: Elsevier
ISSN: 0018-506X
Language: English
Subjects: Attention; Cognition; Cognitive bias; Estradiol; Estrogen; Fertility treatment
Subject (DDC): 150: Psychology
610: Medicine and health
Abstract: The putative association between hormones and cognitive performance is controversial. While there is evidence that estradiol plays a neuroprotective role, hormone treatment has not been shown to improve cognitive performance. Current research is flawed by the evaluation of combined hormonal effects throughout the menstrual cycle or in the menopausal transition. The stimulation phase of a fertility treatment offers a unique model to study the effect of estradiol on cognitive function. This quasi-experimental observational study is based on data from 44 women receiving IVF in Zurich, Switzerland. We assessed visuospatial working memory, attention, cognitive bias, and hormone levels at the beginning and at the end of the stimulation phase of ovarian superstimulation as part of a fertility treatment. In addition to inter-individual differences, we examined intra-individual change over time (within-subject effects). The substantial increases in estradiol levels resulting from fertility treatment did not relate to any considerable change in cognitive functioning. As the tests applied represent a broad variety of cognitive functions on different levels of complexity and with various brain regions involved, we can conclude that estradiol does not show a significant short-term effect on cognitive function.
Fulltext version: Published version
License (according to publishing contract): Licence according to publishing contract
Departement: Applied Psychology
Organisational Unit: Psychological Institute (PI)
Appears in collections:Publikationen Angewandte Psychologie

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