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Publication type: Article in scientific journal
Type of review: Peer review (publication)
Title: Does parental farm upbringing influence the risk of asthma in offspring? : a three-generation study
Authors: Timm, Signe
Svanes, Cecilie
Frydenberg, Morten
Sigsgaard, Torben
Holm, Mathias
Janson, Christer
Bråbäck, Lennart
Campbell, Brittany
Kjaer Madsen, Marie
Jõgi, Nils Oskar
Jõgi, Rain
Schiöler, Linus
Bertelsen, Randi Jacobsen
Johannessen, Ane
Sanchez-Ramos, Jose Luis
Martinez-Moretalla, Jesus
Dratva, Julia
Dharmage, Shyamali
Schlünssen, Vivi
et. al: No
DOI: 10.1093/ije/dyaa091
Published in: International Journal of Epidemiology
Volume(Issue): 49
Issue: 6
Pages: 1874
Pages to: 1882
Issue Date: 3-Aug-2020
Publisher / Ed. Institution: Oxford University Press
ISSN: 0300-5771
Language: English
Subjects: Asthma; ECRHS; RHINESSA; Farm upbringing; Generation study; Generational effects
Subject (DDC): 614: Public health and prevention of disease
616: Internal medicine and diseases
Abstract: Background: A farm upbringing has been associated with lower risk of asthma and methylation of asthma-related genes. As such, a farm upbringing has the potential to transfer asthma risk across generations, but this has never been investigated. We aimed to study the generational effects from a parental farm upbringing on offspring asthma. Methods: Our study involved three generations: 5759 participants from the European Community Respiratory Health Survey (ECRHS) study (born 1945–1971, denoted G1), their 9991 parents (G0) and their 8260 offspring (G2) participating in RHINESSA (Respiratory Health In Northern Europe, Spain and Australia). Questionnaire data were collected on G0 and G1 from G1 in 2010 and on G2 from themselves in 2013. The parental/grandparental place of upbringing was categorized: (i) both parents from farm; (ii) mother from farm, father from village/city; (iii) father from farm, mother from village/city; (iv) both parents from village or one parent from village and one from city; (v) both parents from city (reference group). Grandparental upbringing was equivalently categorized. Offspring asthma was self-reported and data were analysed using Cox-regression models with G2 age as the time scale. Results: A parental farm upbringing was not associated with offspring asthma when compared with city upbringing [hazard ratio (HR) 1.12, 95% confidence interval (CI) 0.74–1.69]. Findings remained similar when stratified by offspring upbringing and asthma phenotypes. Quantitative bias analyses showed similar estimates for alternative data sources. A grandparental farm upbringing was not associated with offspring asthma in either the maternal (HR 1.05, 95% CI 0.67–1.65) or paternal line (HR 1.02, 95% CI 0.62–1.68). Conclusions: This multigenerational analysis suggests no evidence of an association between parental/grandparental farm upbringing and offspring asthma.
Further description: Erworben im Rahmen der Schweizer Nationallizenzen (
Fulltext version: Published version
License (according to publishing contract): Licence according to publishing contract
Restricted until: 2024-01-01
Departement: School of Health Sciences
Organisational Unit: Institute of Public Health (IPH)
Appears in collections:Publikationen Gesundheit

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