Bitte benutzen Sie diese Kennung, um auf die Ressource zu verweisen:
https://doi.org/10.21256/zhaw-21291| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | Does parental farm upbringing influence the risk of asthma in offspring? : a three-generation study |
| Autor/-in: | Timm, Signe Svanes, Cecilie Frydenberg, Morten Sigsgaard, Torben Holm, Mathias Janson, Christer Bråbäck, Lennart Campbell, Brittany Kjaer Madsen, Marie Jõgi, Nils Oskar Jõgi, Rain Schiöler, Linus Bertelsen, Randi Jacobsen Johannessen, Ane Sanchez-Ramos, Jose Luis Martinez-Moretalla, Jesus Dratva, Julia Dharmage, Shyamali Schlünssen, Vivi |
| et. al: | No |
| DOI: | 10.1093/ije/dyaa091 10.21256/zhaw-21291 |
| Erschienen in: | International Journal of Epidemiology |
| Band(Heft): | 49 |
| Heft: | 6 |
| Seite(n): | 1874 |
| Seiten bis: | 1882 |
| Erscheinungsdatum: | 3-Aug-2020 |
| Verlag / Hrsg. Institution: | Oxford University Press |
| ISSN: | 0300-5771 1464-3685 |
| Sprache: | Englisch |
| Schlagwörter: | Asthma; ECRHS; RHINESSA; Farm upbringing; Generation study; Generational effects |
| Fachgebiet (DDC): | 614: Public Health und Gesundheitsförderung 616: Innere Medizin und Krankheiten |
| Zusammenfassung: | Background: A farm upbringing has been associated with lower risk of asthma and methylation of asthma-related genes. As such, a farm upbringing has the potential to transfer asthma risk across generations, but this has never been investigated. We aimed to study the generational effects from a parental farm upbringing on offspring asthma. Methods: Our study involved three generations: 5759 participants from the European Community Respiratory Health Survey (ECRHS) study (born 1945–1971, denoted G1), their 9991 parents (G0) and their 8260 offspring (G2) participating in RHINESSA (Respiratory Health In Northern Europe, Spain and Australia). Questionnaire data were collected on G0 and G1 from G1 in 2010 and on G2 from themselves in 2013. The parental/grandparental place of upbringing was categorized: (i) both parents from farm; (ii) mother from farm, father from village/city; (iii) father from farm, mother from village/city; (iv) both parents from village or one parent from village and one from city; (v) both parents from city (reference group). Grandparental upbringing was equivalently categorized. Offspring asthma was self-reported and data were analysed using Cox-regression models with G2 age as the time scale. Results: A parental farm upbringing was not associated with offspring asthma when compared with city upbringing [hazard ratio (HR) 1.12, 95% confidence interval (CI) 0.74–1.69]. Findings remained similar when stratified by offspring upbringing and asthma phenotypes. Quantitative bias analyses showed similar estimates for alternative data sources. A grandparental farm upbringing was not associated with offspring asthma in either the maternal (HR 1.05, 95% CI 0.67–1.65) or paternal line (HR 1.02, 95% CI 0.62–1.68). Conclusions: This multigenerational analysis suggests no evidence of an association between parental/grandparental farm upbringing and offspring asthma. |
| Weitere Angaben: | Erworben im Rahmen der Schweizer Nationallizenzen (http://www.nationallizenzen.ch) |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/21291 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | Lizenz gemäss Verlagsvertrag |
| Gesperrt bis: | 2024-01-01 |
| Departement: | Gesundheit |
| Organisationseinheit: | Institut für Public Health (IPH) |
| Enthalten in den Sammlungen: | Publikationen Gesundheit |
Dateien zu dieser Ressource:
| Datei | Beschreibung | Größe | Format | |
|---|---|---|---|---|
| 2020_Timm_etal_Parental-farm-upbringing_IEA.pdf | 3.78 MB | Adobe PDF |  Öffnen/Anzeigen |
Zur Langanzeige
Timm, S., Svanes, C., Frydenberg, M., Sigsgaard, T., Holm, M., Janson, C., Bråbäck, L., Campbell, B., Kjaer Madsen, M., Jõgi, N. O., Jõgi, R., Schiöler, L., Bertelsen, R. J., Johannessen, A., Sanchez-Ramos, J. L., Martinez-Moretalla, J., Dratva, J., Dharmage, S., & Schlünssen, V. (2020). Does parental farm upbringing influence the risk of asthma in offspring? : a three-generation study. International Journal of Epidemiology, 49(6), 1874–1882. https://doi.org/10.1093/ije/dyaa091
Timm, S. et al. (2020) ‘Does parental farm upbringing influence the risk of asthma in offspring? : a three-generation study’, International Journal of Epidemiology, 49(6), pp. 1874–1882. Available at: https://doi.org/10.1093/ije/dyaa091.
S. Timm et al., “Does parental farm upbringing influence the risk of asthma in offspring? : a three-generation study,” International Journal of Epidemiology, vol. 49, no. 6, pp. 1874–1882, Aug. 2020, doi: 10.1093/ije/dyaa091.
TIMM, Signe, Cecilie SVANES, Morten FRYDENBERG, Torben SIGSGAARD, Mathias HOLM, Christer JANSON, Lennart BRÅBÄCK, Brittany CAMPBELL, Marie KJAER MADSEN, Nils Oskar JÕGI, Rain JÕGI, Linus SCHIÖLER, Randi Jacobsen BERTELSEN, Ane JOHANNESSEN, Jose Luis SANCHEZ-RAMOS, Jesus MARTINEZ-MORETALLA, Julia DRATVA, Shyamali DHARMAGE und Vivi SCHLÜNSSEN, 2020. Does parental farm upbringing influence the risk of asthma in offspring? : a three-generation study. International Journal of Epidemiology. 3 August 2020. Bd. 49, Nr. 6, S. 1874–1882. DOI 10.1093/ije/dyaa091
Timm, Signe, Cecilie Svanes, Morten Frydenberg, Torben Sigsgaard, Mathias Holm, Christer Janson, Lennart Bråbäck, et al. 2020. “Does Parental Farm Upbringing Influence the Risk of Asthma in Offspring? : A Three-Generation Study.” International Journal of Epidemiology 49 (6): 1874–82. https://doi.org/10.1093/ije/dyaa091.
Timm, Signe, et al. “Does Parental Farm Upbringing Influence the Risk of Asthma in Offspring? : A Three-Generation Study.” International Journal of Epidemiology, vol. 49, no. 6, Aug. 2020, pp. 1874–82, https://doi.org/10.1093/ije/dyaa091.
Alle Ressourcen in diesem Repository sind urheberrechtlich geschützt, soweit nicht anderweitig angezeigt.