Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-21011
Publication type: Article in scientific journal
Type of review: Peer review (publication)
Title: Oxygen mass transfer in biopharmaceutical processes : numerical and experimental approaches 
Authors: Seidel, Stefan
Maschke, Rüdiger
Werner, Sören
Jossen, Valentin
Eibl, Dieter
et. al: No
DOI: 10.1002/cite.202000179
10.21256/zhaw-21011
Published in: Chemie Ingenieur Technik
Volume(Issue): 93
Issue: 1-2
Issue Date: 7-Dec-2020
Publisher / Ed. Institution: Wiley
ISSN: 0009-286X
1522-2640
Language: English
Subjects: Bioreactor; CFD simulation; Multiphase modeling; Oxygen transfer rate; Population balance modeling
Subject (DDC): 660: Chemical engineering
Abstract: Oxygen supply in aerobic bioprocesses is of crucial importance. For this reason, this paper presents the oxygen demand of different cells and summarizes experimental and numerical possibilities for the determination of oxygen transfer in bioreactors. The focus lies on the volumetric oxygen mass transfer coefficient (kLa) calculation using computational fluid dynamics and state-of-the-art models for surface-aerated and forced-aerated bioreactors. In addition, experimental methods for the determination of the kLa value and the gas bubble size distribution are presented.
URI: https://digitalcollection.zhaw.ch/handle/11475/21011
Fulltext version: Published version
License (according to publishing contract): CC BY 4.0: Attribution 4.0 International
Departement: Life Sciences and Facility Management
Organisational Unit: Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:Publikationen Life Sciences und Facility Management

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