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https://doi.org/10.21256/zhaw-21011| Publication type: | Article in scientific journal |
| Type of review: | Peer review (publication) |
| Title: | Oxygen mass transfer in biopharmaceutical processes : numerical and experimental approaches |
| Authors: | Seidel, Stefan Maschke, Rüdiger Werner, Sören Jossen, Valentin Eibl, Dieter |
| et. al: | No |
| DOI: | 10.1002/cite.202000179 10.21256/zhaw-21011 |
| Published in: | Chemie Ingenieur Technik |
| Volume(Issue): | 93 |
| Issue: | 1-2 |
| Issue Date: | 7-Dec-2020 |
| Publisher / Ed. Institution: | Wiley |
| ISSN: | 0009-286X 1522-2640 |
| Language: | English |
| Subjects: | Bioreactor; CFD simulation; Multiphase modeling; Oxygen transfer rate; Population balance modeling |
| Subject (DDC): | 660: Chemical engineering |
| Abstract: | Oxygen supply in aerobic bioprocesses is of crucial importance. For this reason, this paper presents the oxygen demand of different cells and summarizes experimental and numerical possibilities for the determination of oxygen transfer in bioreactors. The focus lies on the volumetric oxygen mass transfer coefficient (kLa) calculation using computational fluid dynamics and state-of-the-art models for surface-aerated and forced-aerated bioreactors. In addition, experimental methods for the determination of the kLa value and the gas bubble size distribution are presented. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/21011 |
| Fulltext version: | Published version |
| License (according to publishing contract): | CC BY 4.0: Attribution 4.0 International |
| Departement: | Life Sciences and Facility Management |
| Organisational Unit: | Institute of Chemistry and Biotechnology (ICBT) |
| Appears in collections: | Publikationen Life Sciences und Facility Management |
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|---|---|---|---|---|
| 2020_Seidel_et-al_Oxygen-mass-transfer_CITE.pdf | 2.23 MB | Adobe PDF |  View/Open |
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Seidel, S., Maschke, R., Werner, S., Jossen, V., & Eibl, D. (2020). Oxygen mass transfer in biopharmaceutical processes : numerical and experimental approaches . Chemie Ingenieur Technik, 93(1-2). https://doi.org/10.1002/cite.202000179
Seidel, S. et al. (2020) ‘Oxygen mass transfer in biopharmaceutical processes : numerical and experimental approaches ’, Chemie Ingenieur Technik, 93(1-2). Available at: https://doi.org/10.1002/cite.202000179.
S. Seidel, R. Maschke, S. Werner, V. Jossen, and D. Eibl, “Oxygen mass transfer in biopharmaceutical processes : numerical and experimental approaches ,” Chemie Ingenieur Technik, vol. 93, no. 1-2, Dec. 2020, doi: 10.1002/cite.202000179.
SEIDEL, Stefan, Rüdiger MASCHKE, Sören WERNER, Valentin JOSSEN und Dieter EIBL, 2020. Oxygen mass transfer in biopharmaceutical processes : numerical and experimental approaches . Chemie Ingenieur Technik. 7 Dezember 2020. Bd. 93, Nr. 1-2. DOI 10.1002/cite.202000179
Seidel, Stefan, Rüdiger Maschke, Sören Werner, Valentin Jossen, and Dieter Eibl. 2020. “Oxygen Mass Transfer in Biopharmaceutical Processes : Numerical and Experimental Approaches .” Chemie Ingenieur Technik 93 (1-2). https://doi.org/10.1002/cite.202000179.
Seidel, Stefan, et al. “Oxygen Mass Transfer in Biopharmaceutical Processes : Numerical and Experimental Approaches .” Chemie Ingenieur Technik, vol. 93, no. 1-2, Dec. 2020, https://doi.org/10.1002/cite.202000179.
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