Comparative efficacy of placebos in short-term antidepressant trials for major depression : a secondary meta-analysis of placebo-controlled trials

Holper, Lisa; Hengartner, Michael Pascal

doi:10.1186/s12888-020-02839-y

Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-20474

Publication type:	Article in scientific journal
Type of review:	Open peer review
Title:	Comparative efficacy of placebos in short-term antidepressant trials for major depression : a secondary meta-analysis of placebo-controlled trials
Authors:	Holper, Lisa Hengartner, Michael Pascal
et. al:	No
DOI:	10.1186/s12888-020-02839-y 10.21256/zhaw-20474
Published in:	BMC Psychiatry
Volume(Issue):	20
Issue:	1
Page(s):	437
Issue Date:	2020
Publisher / Ed. Institution:	BioMed Central
ISSN:	1471-244X
Language:	English
Subjects:	Antidepressants; Bayesian network meta-analysis; Placebo; Side-effects; Unblinding
Subject (DDC):	615: Pharmacology and therapeutics 616.8: Neurology, diseases of nervous system
Abstract:	The issue of unblinded outcome-assessors and patients has repeatedly been stressed as a flaw in allegedly double-blind antidepressant trials. Unblinding bias can for example result from a drug's marked side effects. If such unblinding bias is present for a given drug, then it might be expected that the placebos of that drug are rated significantly less effective than that of other antidepressants.
URI:	https://digitalcollection.zhaw.ch/handle/11475/20474
Fulltext version:	Published version
License (according to publishing contract):	CC BY 4.0: Attribution 4.0 International
Departement:	Applied Psychology
Organisational Unit:	Psychological Institute (PI)
Appears in collections:	Publikationen Angewandte Psychologie

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Holper, L., & Hengartner, M. P. (2020). Comparative efficacy of placebos in short-term antidepressant trials for major depression : a secondary meta-analysis of placebo-controlled trials. BMC Psychiatry, 20(1), 437. https://doi.org/10.1186/s12888-020-02839-y

Holper, L. and Hengartner, M.P. (2020) ‘Comparative efficacy of placebos in short-term antidepressant trials for major depression : a secondary meta-analysis of placebo-controlled trials’, BMC Psychiatry, 20(1), p. 437. Available at: https://doi.org/10.1186/s12888-020-02839-y.

L. Holper and M. P. Hengartner, “Comparative efficacy of placebos in short-term antidepressant trials for major depression : a secondary meta-analysis of placebo-controlled trials,” BMC Psychiatry, vol. 20, no. 1, p. 437, 2020, doi: 10.1186/s12888-020-02839-y.

HOLPER, Lisa und Michael Pascal HENGARTNER, 2020. Comparative efficacy of placebos in short-term antidepressant trials for major depression : a secondary meta-analysis of placebo-controlled trials. BMC Psychiatry. 2020. Bd. 20, Nr. 1, S. 437. DOI 10.1186/s12888-020-02839-y

Holper, Lisa, and Michael Pascal Hengartner. 2020. “Comparative Efficacy of Placebos in Short-Term Antidepressant Trials for Major Depression : A Secondary Meta-Analysis of Placebo-Controlled Trials.” BMC Psychiatry 20 (1): 437. https://doi.org/10.1186/s12888-020-02839-y.

Holper, Lisa, and Michael Pascal Hengartner. “Comparative Efficacy of Placebos in Short-Term Antidepressant Trials for Major Depression : A Secondary Meta-Analysis of Placebo-Controlled Trials.” BMC Psychiatry, vol. 20, no. 1, 2020, p. 437, https://doi.org/10.1186/s12888-020-02839-y.